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Aliases for MTRNR2L4 Gene

Aliases for MTRNR2L4 Gene

  • MT-RNR2 Like 4 2 3
  • Humanin-Like 4 2 3
  • MT-RNR2-Like 4 2 5
  • HN4 3 4
  • Humanin-Like Protein 4 3
  • MT-RNR2-Like Protein 4 4
  • MTRNR2-Like 4 3

External Ids for MTRNR2L4 Gene

Previous GeneCards Identifiers for MTRNR2L4 Gene

  • GC16U901199
  • GC16M003429
  • GC16M003435
  • GC16M003439
  • GC16M003444
  • GC16M003450
  • GC16M003454
  • GC16M003458
  • GC16M003463

Summaries for MTRNR2L4 Gene

GeneCards Summary for MTRNR2L4 Gene

MTRNR2L4 (MT-RNR2 Like 4) is a Protein Coding gene. Diseases associated with MTRNR2L4 include Third Cranial Nerve Disease and Oculomotor Nerve Paralysis. An important paralog of this gene is MTRNR2L5.

UniProtKB/Swiss-Prot for MTRNR2L4 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

Additional gene information for MTRNR2L4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L4 Gene

Genomics for MTRNR2L4 Gene

GeneHancer (GH) Regulatory Elements for MTRNR2L4 Gene

Promoters and enhancers for MTRNR2L4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002511 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 +856.3 856287 10.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ATP6V0C AMDHD2 ENSG00000279520 ZNF75A TBC1D24 IFT140 ZNF213-AS1 CRAMP1 ERVK13-1 SNHG19
GH16J002473 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.3 +897.4 897423 3.5 ATF1 FOXA2 ARID4B SIN3A ZNF48 POLR2B GLIS2 ZNF143 ZNF207 KLF13 TBC1D24 ENSG00000260293 GC16P002476 IFT140 ZNF75A TIGD7 NME3 ZNF213-AS1 ZSCAN32 ZNF174
GH16J003156 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +213.9 213946 3.8 DMAP1 YY1 ZNF213 E2F8 SP3 MEF2D SSRP1 ZNF610 GLIS1 NBN GC16M003157 TRK-CTT3-1 TRP-TGG3-3 ZNF75A E4F1 ZNF213-AS1 ZNF205 ENSG00000261938 CREBBP ZNF263
GH16J003636 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 11.4 -267.6 -267579 6.8 FOXA2 ARID4B FOS ATF7 RUNX3 SP5 ZNF592 SMARCA4 ZNF585B RCOR2 DNASE1 PIR33321 CLUAP1 ZNF75A TIGD7 ZNF213-AS1 TRAP1 ZSCAN32 ZNF174 FLYWCH2
GH16J004182 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 11.3 -811.0 -811048 2.4 HDGF HNRNPUL1 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 LOC105371062 GC16P004182 CREBBP ZNF500 ZNF597 ZNF75A ZNF263 UBN1 ANKS3 ZNF174
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MTRNR2L4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MTRNR2L4 Gene

Genomic Locations for MTRNR2L4 Gene
chr16:3,370,979-3,372,740
(GRCh38/hg38)
Size:
1,762 bases
Orientation:
Minus strand
chr16:3,421,053-3,422,283
(GRCh37/hg19)
Size:
1,231 bases
Orientation:
Minus strand

Genomic View for MTRNR2L4 Gene

Genes around MTRNR2L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L4 Gene

Proteins for MTRNR2L4 Gene

  • Protein details for MTRNR2L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ71-HMN4_HUMAN
    Recommended name:
    Humanin-like 4
    Protein Accession:
    P0CJ71

    Protein attributes for MTRNR2L4 Gene

    Size:
    28 amino acids
    Molecular mass:
    3247 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L4 Gene

Post-translational modifications for MTRNR2L4 Gene

No Post-translational modifications

Other Protein References for MTRNR2L4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L4 Gene

Domains & Families for MTRNR2L4 Gene

Gene Families for MTRNR2L4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MTRNR2L4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTRNR2L4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CJ71

UniProtKB/Swiss-Prot:

HMN4_HUMAN :
  • Belongs to the humanin family.
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L4: view

Function for MTRNR2L4 Gene

Molecular function for MTRNR2L4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Expression is not affected following staurosporine (STS) treatment. Down-regulated 6 hours following beta-carotene treatment, remains down-regulated 24 hours following beta-carotene treatment.

Phenotypes From GWAS Catalog for MTRNR2L4 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTRNR2L4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L4 Gene

Localization for MTRNR2L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L4 Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTRNR2L4 gene
Compartment Confidence
extracellular 4
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MTRNR2L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTRNR2L4 Gene

Pathways & Interactions for MTRNR2L4 Gene

SuperPathways for MTRNR2L4 Gene

No Data Available

Interacting Proteins for MTRNR2L4 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L4 Gene

Drugs & Compounds for MTRNR2L4 Gene

No Compound Related Data Available

Transcripts for MTRNR2L4 Gene

mRNA/cDNA for MTRNR2L4 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L4 Gene

MT-RNR2-like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTRNR2L4

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L4 Gene

No ASD Table

Relevant External Links for MTRNR2L4 Gene

GeneLoc Exon Structure for
MTRNR2L4
ECgene alternative splicing isoforms for
MTRNR2L4

Expression for MTRNR2L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTRNR2L4 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L4 Gene

This gene is overexpressed in Ovary (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of MTRNR2L4 Gene:

MTRNR2L4

SOURCE GeneReport for Unigene cluster for MTRNR2L4 Gene:

Hs.639648

mRNA Expression by UniProt/SwissProt for MTRNR2L4 Gene:

P0CJ71-HMN4_HUMAN
Tissue specificity: Highly expressed in testis. Also expressed in kidney, heart, skeletal muscles and brain.
genes like me logo Genes that share expression patterns with MTRNR2L4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTRNR2L4 Gene

Orthologs for MTRNR2L4 Gene

Evolution for MTRNR2L4 Gene

ENSEMBL:
Gene Tree for MTRNR2L4 (if available)
TreeFam:
Gene Tree for MTRNR2L4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MTRNR2L4: view image

No data available for Orthologs for MTRNR2L4 Gene

Paralogs for MTRNR2L4 Gene

Paralogs for MTRNR2L4 Gene

(2) SIMAP similar genes for MTRNR2L4 Gene using alignment to 1 proteins:

  • HMN4_HUMAN
genes like me logo Genes that share paralogs with MTRNR2L4: view

Variants for MTRNR2L4 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L4 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000154674 -- 3,371,576(-) C/G 3_prime_UTR_variant
rs1001331142 -- 3,371,863(-) T/C coding_sequence_variant, missense_variant
rs1001615442 -- 3,371,644(-) C/T 3_prime_UTR_variant
rs1001891657 -- 3,372,689(-) A/T upstream_transcript_variant
rs1003067623 -- 3,371,702(-) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L4 Gene

Variant ID Type Subtype PubMed ID
dgv2694n100 CNV gain 25217958
dgv2695n100 CNV gain 25217958
dgv476e199 CNV deletion 23128226
esv3637664 CNV loss 21293372
nsv1044147 CNV loss 25217958
nsv1054969 CNV loss 25217958
nsv1714 CNV insertion 18451855
nsv974749 CNV duplication 23825009

Additional Variant Information for MTRNR2L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTRNR2L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MTRNR2L4 Gene

Disorders for MTRNR2L4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MTRNR2L4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
third cranial nerve disease
  • oculomotor nerve paralysis
oculomotor nerve paralysis
  • iii nerve palsy
ametropic amblyopia
  • refractive amblyopia
asthenopia
  • accommodative strain
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MTRNR2L4

genes like me logo Genes that share disorders with MTRNR2L4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTRNR2L4 Gene

Publications for MTRNR2L4 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M … Dembinska-Kiec A (Genomics 2009) 2 3 4 58
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58
  3. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C … Breton S (Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis 2016) 3 58
  4. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C … Cohen P (Trends in endocrinology and metabolism: TEM 2013) 3 58
  5. Immunolocalization of humanin in human sperm and testis. (PMID: 20542501) Moretti E … Collodel G (Fertility and sterility 2010) 3 58

Products for MTRNR2L4 Gene

Sources for MTRNR2L4 Gene

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