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Aliases for MTRNR2L3 Gene

Aliases for MTRNR2L3 Gene

  • MT-RNR2-Like 3 2 3 5
  • Humanin-Like 3 2 3
  • HN3 3 4
  • Humanin-Like Protein 3 3
  • MT-RNR2-Like Protein 3 4
  • MTRNR2-Like 3 3

External Ids for MTRNR2L3 Gene

Previous GeneCards Identifiers for MTRNR2L3 Gene

  • GC20U900575
  • GC20M055937
  • GC20M055938
  • GC20M055939
  • GC20M055941
  • GC20M055944
  • GC20M055947
  • GC20M055952
  • GC20M055956
  • GC20M057359
  • GC20M057360
  • GC20M057361
  • GC20M057362
  • GC20M057363
  • GC20M057364
  • GC20M057365

Summaries for MTRNR2L3 Gene

GeneCards Summary for MTRNR2L3 Gene

MTRNR2L3 (MT-RNR2-Like 3) is a Protein Coding gene. An important paralog of this gene is MTRNR2L1.

UniProtKB/Swiss-Prot for MTRNR2L3 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

Additional gene information for MTRNR2L3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L3 Gene

Genomics for MTRNR2L3 Gene

GeneHancer (GH) Regulatory Elements for MTRNR2L3 Gene

Promoters and enhancers for MTRNR2L3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I057360 Enhancer 0.6 ENCODE 550.8 -1.6 -1562 1.7 SMARCE1 ZNF217 JUND GATA3 RFX1 CREB1 FOS RFX5 MTRNR2L3 BMP7 RAE1 RBM38
GH20I057359 Promoter 0.5 EPDnew 550.8 +0.8 767 0.1 GC20M057367 MTND1P9 MTRNR2L3 NMTRL-TAA5-1 LOC100291105 RBM38 RAE1
GH20I057361 Promoter 0.5 EPDnew 550.8 +0.0 37 0.1 GC20M057367 MTND1P9 MTRNR2L3 NMTRL-TAA5-1 RAE1
GH20I057495 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.3 -135.3 -135300 0.6 HDAC1 ELF3 PKNOX1 RB1 ARNT SIN3A IRF4 ZBTB40 ZSCAN9 RAD21 LOC100291105 RBM38 MTND1P9 MTRNR2L3 RAE1 CTCFL PCK1 HMGB1P1
GH20I057498 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.3 -138.7 -138721 0.6 CTCF RB1 SIN3A EBF1 RAD21 GLIS2 ZNF143 ZNF444 IKZF2 CHD2 LOC100291105 RBM38 MTRNR2L3 RAE1 MTND1P9 CTCFL PCK1 HMGB1P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MTRNR2L3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MTRNR2L3 Gene

Genomic Locations for MTRNR2L3 Gene
1,541 bases
Minus strand

Genomic View for MTRNR2L3 Gene

Genes around MTRNR2L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L3 Gene

Proteins for MTRNR2L3 Gene

  • Protein details for MTRNR2L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Humanin-like 3
    Protein Accession:

    Protein attributes for MTRNR2L3 Gene

    24 amino acids
    Molecular mass:
    2796 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L3 Gene

Post-translational modifications for MTRNR2L3 Gene

No Post-translational modifications

Other Protein References for MTRNR2L3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L3 Gene

Domains & Families for MTRNR2L3 Gene

Gene Families for MTRNR2L3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MTRNR2L3 Gene


Suggested Antigen Peptide Sequences for MTRNR2L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the humanin family.
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L3: view

Function for MTRNR2L3 Gene

Molecular function for MTRNR2L3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, while it is up-regulated 24 hours following beta-carotene treatment.

Phenotypes From GWAS Catalog for MTRNR2L3 Gene

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L3 Gene

Localization for MTRNR2L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L3 Gene

Secreted. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTRNR2L3 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for MTRNR2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTRNR2L3 Gene

Pathways & Interactions for MTRNR2L3 Gene

SuperPathways for MTRNR2L3 Gene

No Data Available

Interacting Proteins for MTRNR2L3 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L3 Gene


No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L3 Gene

Drugs & Compounds for MTRNR2L3 Gene

No Compound Related Data Available

Transcripts for MTRNR2L3 Gene

mRNA/cDNA for MTRNR2L3 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L3 Gene

No ASD Table

Relevant External Links for MTRNR2L3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTRNR2L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTRNR2L3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTRNR2L3 Gene:


SOURCE GeneReport for Unigene cluster for MTRNR2L3 Gene:


mRNA Expression by UniProt/SwissProt for MTRNR2L3 Gene:

Tissue specificity: Highly expressed in testis. Also expressed in kidney, heart, skeletal muscles and brain.
genes like me logo Genes that share expression patterns with MTRNR2L3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTRNR2L3 Gene

Orthologs for MTRNR2L3 Gene

Evolution for MTRNR2L3 Gene

Gene Tree for MTRNR2L3 (if available)
Gene Tree for MTRNR2L3 (if available)

No data available for Orthologs for MTRNR2L3 Gene

Paralogs for MTRNR2L3 Gene

Paralogs for MTRNR2L3 Gene

(2) SIMAP similar genes for MTRNR2L3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L3: view

Variants for MTRNR2L3 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L3 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000355948 -- 57,361,804(-) G/A upstream_transcript_variant
rs1000820725 -- 57,358,199(-) G/A downstream_transcript_variant
rs1000915623 -- 57,358,056(-) T/C downstream_transcript_variant
rs1001698880 -- 57,358,857(-) A/G 3_prime_UTR_variant
rs1002961310 -- 57,360,016(-) TCTTCT/TCT upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L3 Gene

Variant ID Type Subtype PubMed ID
nsv965892 CNV duplication 23825009
nsv586311 CNV loss 21841781
nsv459027 CNV loss 19166990
nsv1055983 CNV gain 25217958

Variation tolerance for MTRNR2L3 Gene

Gene Damage Index Score: 2.30; 41.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTRNR2L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRNR2L3 Gene

Disorders for MTRNR2L3 Gene

Additional Disease Information for MTRNR2L3

No disorders were found for MTRNR2L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTRNR2L3 Gene

Publications for MTRNR2L3 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M … Dembinska-Kiec A (Genomics 2009) 2 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  3. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C … Breton S (Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis 2016) 3 58
  4. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C … Cohen P (Trends in endocrinology and metabolism: TEM 2013) 3 58
  5. Immunolocalization of humanin in human sperm and testis. (PMID: 20542501) Moretti E … Collodel G (Fertility and sterility 2010) 3 58

Products for MTRNR2L3 Gene

Sources for MTRNR2L3 Gene

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