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Aliases for MTRNR2L10 Gene

Aliases for MTRNR2L10 Gene

  • MT-RNR2 Like 10 2 3
  • Humanin-Like 10 2 3
  • HN10 3 4
  • Humanin-Like Protein 10 3
  • MT-RNR2-Like Protein 10 4
  • MT-RNR2-Like 10 5
  • MTRNR2-Like 10 3

External Ids for MTRNR2L10 Gene

Previous GeneCards Identifiers for MTRNR2L10 Gene

  • GC0XU901540
  • GC0XM055217
  • GC0XM055243
  • GC0XM055247
  • GC0XM055253
  • GC0XM055261
  • GC0XM055266
  • GC0XM055270
  • GC0XM055274
  • GC0XM055182
  • GC0XM055184
  • GC0XM055187
  • GC0XM055189
  • GC0XM055191
  • GC0XM055193
  • GC0XM055195
  • GC0XM055197

Summaries for MTRNR2L10 Gene

GeneCards Summary for MTRNR2L10 Gene

MTRNR2L10 (MT-RNR2 Like 10) is a Protein Coding gene. An important paralog of this gene is MTRNR2L13.

UniProtKB/Swiss-Prot for MTRNR2L10 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

Additional gene information for MTRNR2L10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L10 Gene

Genomics for MTRNR2L10 Gene

GeneHancer (GH) Regulatory Elements for MTRNR2L10 Gene

Promoters and enhancers for MTRNR2L10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ055181 Enhancer 0.2 Ensembl 650.7 +1.3 1319 0.4 GC0XM055181 GC0XM055201 GC0XP055181 MTND1P30 MTND2P24 MTRNR2L10 NMTRQ-TTG1-1 FAM104B LOC101060042
GH0XJ055183 Enhancer 0.2 Ensembl 650.7 -0.7 -680 0.4 MTRNR2L10 GC0XP055190 LOC101060042
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MTRNR2L10 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MTRNR2L10 Gene

Genomic Locations for MTRNR2L10 Gene
chrX:55,181,391-55,182,920
(GRCh38/hg38)
Size:
1,530 bases
Orientation:
Minus strand
chrX:55,207,824-55,208,944
(GRCh37/hg19)

Genomic View for MTRNR2L10 Gene

Genes around MTRNR2L10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L10 Gene

Proteins for MTRNR2L10 Gene

  • Protein details for MTRNR2L10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ77-HMN10_HUMAN
    Recommended name:
    Humanin-like 10
    Protein Accession:
    P0CJ77

    Protein attributes for MTRNR2L10 Gene

    Size:
    24 amino acids
    Molecular mass:
    2806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L10 Gene

Post-translational modifications for MTRNR2L10 Gene

No Post-translational modifications

Other Protein References for MTRNR2L10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L10 Gene

Domains & Families for MTRNR2L10 Gene

Gene Families for MTRNR2L10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MTRNR2L10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTRNR2L10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CJ77

UniProtKB/Swiss-Prot:

HMN10_HUMAN :
  • Belongs to the humanin family.
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L10: view

Function for MTRNR2L10 Gene

Molecular function for MTRNR2L10 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, while it is up-regulated 24 hours following beta-carotene treatment.

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTRNR2L10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L10 Gene

Localization for MTRNR2L10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L10 Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTRNR2L10 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for MTRNR2L10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTRNR2L10 Gene

Pathways & Interactions for MTRNR2L10 Gene

SuperPathways for MTRNR2L10 Gene

No Data Available

Interacting Proteins for MTRNR2L10 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L10 Gene

Drugs & Compounds for MTRNR2L10 Gene

No Compound Related Data Available

Transcripts for MTRNR2L10 Gene

mRNA/cDNA for MTRNR2L10 Gene

(0) Additional mRNA sequences :
-
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L10 Gene

MT-RNR2-like 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTRNR2L10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L10 Gene

No ASD Table

Relevant External Links for MTRNR2L10 Gene

GeneLoc Exon Structure for
MTRNR2L10
ECgene alternative splicing isoforms for
MTRNR2L10

Expression for MTRNR2L10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTRNR2L10 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTRNR2L10 Gene:

MTRNR2L10

SOURCE GeneReport for Unigene cluster for MTRNR2L10 Gene:

Hs.722730

mRNA Expression by UniProt/SwissProt for MTRNR2L10 Gene:

P0CJ77-HMN10_HUMAN
Tissue specificity: Expressed in mature brain, thyroid gland and testis.
genes like me logo Genes that share expression patterns with MTRNR2L10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTRNR2L10 Gene

Orthologs for MTRNR2L10 Gene

Evolution for MTRNR2L10 Gene

ENSEMBL:
Gene Tree for MTRNR2L10 (if available)
TreeFam:
Gene Tree for MTRNR2L10 (if available)

No data available for Orthologs for MTRNR2L10 Gene

Paralogs for MTRNR2L10 Gene

Paralogs for MTRNR2L10 Gene

(2) SIMAP similar genes for MTRNR2L10 Gene using alignment to 1 proteins:

  • HMN10_HUMAN
genes like me logo Genes that share paralogs with MTRNR2L10: view

Variants for MTRNR2L10 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L10 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1001950066 -- 55,181,235(-) C/A downstream_transcript_variant
rs1004525456 -- 55,180,924(-) C/A/T downstream_transcript_variant
rs1005102613 -- 55,183,638(-) A/G upstream_transcript_variant
rs1005176092 -- 55,183,967(-) T/A upstream_transcript_variant
rs1006197631 -- 55,184,094(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L10 Gene

Variant ID Type Subtype PubMed ID
esv2740175 CNV deletion 23290073
esv2740181 CNV deletion 23290073
nsv435891 CNV deletion 17901297

Variation tolerance for MTRNR2L10 Gene

Gene Damage Index Score: 0.65; 13.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTRNR2L10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTRNR2L10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRNR2L10 Gene

Disorders for MTRNR2L10 Gene

Additional Disease Information for MTRNR2L10

No disorders were found for MTRNR2L10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTRNR2L10 Gene

Publications for MTRNR2L10 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M … Dembinska-Kiec A (Genomics 2009) 2 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C … Breton S (Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis 2016) 3 58
  4. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C … Cohen P (Trends in endocrinology and metabolism: TEM 2013) 3 58
  5. Immunolocalization of humanin in human sperm and testis. (PMID: 20542501) Moretti E … Collodel G (Fertility and sterility 2010) 3 58

Products for MTRNR2L10 Gene

Sources for MTRNR2L10 Gene

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