Aliases for MTOR Gene
Aliases for MTOR Gene
- Mechanistic Target Of Rapamycin Kinase 2 3 5
- Rapamycin And FKBP12 Target 1 2 3 4
- Mammalian Target Of Rapamycin 2 3 4
- FK506-Binding Protein 12-Rapamycin Complex-Associated Protein 1 3 4
- Mechanistic Target Of Rapamycin (Serine/Threonine Kinase) 2 3
- FK506 Binding Protein 12-Rapamycin Associated Protein 2 2 3
- FKBP12-Rapamycin Complex-Associated Protein 1 2 3
- Rapamycin Associated Protein FRAP2 2 3
- FKBP-Rapamycin Associated Protein 2 3
- Mechanistic Target Of Rapamycin 2 4
- Rapamycin Target Protein 1 3 4
- FRAP1 3 4
- FRAP2 3 4
External Ids for MTOR Gene
- HGNC: 3942
- Entrez Gene: 2475
- Ensembl: ENSG00000198793
- OMIM: 601231
- UniProtKB: P42345
Previous HGNC Symbols for MTOR Gene
- FRAP
- FRAP2
- FRAP1
Previous GeneCards Identifiers for MTOR Gene
- GC01M011089
- GC01M010317
Summaries for MTOR Gene
-
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
-
mTOR deregulation has been observed in many cancer types. As a part of the PI3K/Akt pathway, there is a broad interest in mTOR biology across cancer types. mTOR inhibition has been investigated for nearly a decade. Everolimus, temsirolimus and zotarolimus are three of the more commonly used mTOR inhibitors used in clinical treatment today, with modest success.
GeneCards Summary for MTOR Gene
MTOR (Mechanistic Target Of Rapamycin Kinase) is a Protein Coding gene. Diseases associated with MTOR include Smith-Kingsmore Syndrome and Focal Cortical Dysplasia, Type Ii. Among its related pathways are Metformin Pathway, Pharmacodynamics and MET promotes cell motility. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity.
UniProtKB/Swiss-Prot for MTOR Gene
-
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at Ser-758, disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at Ser-473 of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at Ser-422 (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity).
Additional gene information for MTOR Gene
- Monarch Initiative
- Search for MTOR at DataMed
- Search for MTOR at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTOR Gene
Genomics for MTOR Gene
GeneHancer (GH) Regulatory Elements for MTOR Gene
Promoters and enhancers for MTOR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MTOR on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MTOR Gene
Genomic Locations for MTOR Gene
- chr1:11,106,531-11,262,557
- (GRCh38/hg38)
- Size:
- 156,027 bases
- Orientation:
- Minus strand
- chr1:11,166,588-11,322,608
- (GRCh37/hg19)
Genomic View for MTOR Gene
Genes around MTOR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.22 by Ensembl
- 1p36.22 by Entrez Gene
- 1p36.22 by HGNC
MTOR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MTOR Gene
Proteins for MTOR Gene
-
Protein details for MTOR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P42345-MTOR_HUMAN
- Recommended name:
- Serine/threonine-protein kinase mTOR
- Protein Accession:
- P42345
- Q4LE76
- Q5TER1
- Q6LE87
- Q96QG3
- Q9Y4I3
Protein attributes for MTOR Gene
- Size:
- 2549 amino acids
- Molecular mass:
- 288892 Da
- Quaternary structure:
-
- Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. The mTORC1 complex is a 1 Md obligate dimer of two stoichiometric heterotetramers with overall dimensions of 290 A x 210 A x 135 A. It has a rhomboid shape and a central cavity, the dimeric interfaces are formed by interlocking interactions between the two MTOR and the two RPTOR subunits. The MLST8 subunit forms distal foot-like protuberances, and contacts only one MTOR within the complex, while the small PRAS40 localizes to the midsection of the central core, in close proximity to RPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with PLPP7 and PML. Interacts with PRR5 and RICTOR; the interaction is direct within the mTORC2 complex. Interacts with WAC; WAC positively regulates MTOR activity by promoting the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex which leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). Interacts with UBQLN1. Interacts with TTI1 and TELO2. Interacts with CLIP1; phosphorylates and regulates CLIP1. Interacts with NBN. Interacts with HTR6 (PubMed:23027611). Interacts with BRAT1.
- SequenceCaution:
-
- Sequence=AAC39933.1; Type=Frameshift; Positions=956, 999; Evidence={ECO:0000305}; Sequence=BAE06077.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for MTOR Gene
Post-translational modifications for MTOR Gene
- Autophosphorylates when part of mTORC1 or mTORC2. Phosphorylation at Ser-1261, Ser-2159 and Thr-2164 promotes autophosphorylation. Phosphorylation in the kinase domain modulates the interactions of MTOR with RPTOR and PRAS40 and leads to increased intrinsic mTORC1 kinase activity. Phosphorylation at Thr-2173 in the ATP-binding region by AKT1 strongly reduces kinase activity.
- Ubiquitination at Lys309, Lys616, isoforms=1293, isoforms=1635, Lys1655, and Lys2166
- Modification sites at PhosphoSitePlus
Other Protein References for MTOR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MTOR (TOR)
-
Custom Antibody ServicesOriGene Antibodies for MTOR
- CF806117
- TA806117
- CF806072
- TA806072
- CF806066
- TA806066
- CF805945
- TA805945
- CF805942
- TA805942
- CF805930
- TA805930
- CF805914
- TA805914
- CF805913
- TA805913
- CF805908
- TA805908
- CF805901
- TA805901
- CF805816
- TA805816
- TA590835
- TA353962
- TA333255
- TA332740
- TA325699
- TA325698
- TA325697
- TA325696
- TA322695
- TA322694
- TA310067
- R1472P
- AP55871PU-S
- AP55871PU-N
- AP20987PU-N
- AP20896PU-N
- AP20800PU-N
- AP20712PU-N
- AP09511PU-S
- AP09511PU-N
- AP09299PU-N
- AP08060PU-S
- AP08060PU-N
- AP07823PU-N
- AP07537PU-N
- AP07300PU-N
- AP06628PU-N
- AP06541PU-N
- AP02480PU-S
- AP02480PU-N
- TA306210
- TA302216
- TA300537
- Novus Biologicals Antibodies for MTOR
-
Abcam antibodies for MTOR
-
Cloud-Clone Corp. Antibodies for MTOR
- Invitrogen Antibodies for MTOR
- antibodies-online: Search results for 376 available MTOR Antibodies ranked by validation data
- Compare Top MTOR Antibodies
-
Recommended
- 1 PLA Antibody (anti-rat)
- 9 IP Antibodies (anti-rat)
- 11 IHC Antibodies (anti-rat)
- 15 IHC (p) Antibodies (anti-rat)
- 48 IF (p) Antibodies (anti-rat)
- 106 WB Antibodies (anti-rat)
- 1 PLA Antibody (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 13 IHC Antibodies (anti-mouse)
- 15 IHC (p) Antibodies (anti-mouse)
- 48 IF (p) Antibodies (anti-mouse)
- 110 WB Antibodies (anti-mouse)
- 1 PLA Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 2 DB Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 12 IP Antibodies (anti-human)
- 17 IHC Antibodies (anti-human)
- 22 IHC (p) Antibodies (anti-human)
- 48 IF (p) Antibodies (anti-human)
- 252 WB Antibodies (anti-human)
- GeneTex MTOR antibody for MTOR
-
Custom Antibody ServicesProSci Antibodies for MTOR
-
Santa Cruz Biotechnology (SCBT) Antibodies for MTOR
Protein Products
-
OriGene Purified Proteins for MTOR
- Search Origene for MassSpec and Protein Over-expression Lysates for MTOR
- Origene Custom Protein Services for MTOR
-
Cloud-Clone Corp. Proteins for MTOR
- Search GeneTex for Proteins for MTOR
-
Abcam proteins for MTOR
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for MTOR (TOR)
- Novus Biologicals ELISA Kits for MTOR
-
Cloud-Clone Corp. Assay Kits for MTOR
-
Abcam assays for MTOR
No data available for DME Specific Peptides for MTOR Gene
Domains & Families for MTOR Gene
Gene Families for MTOR Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MTOR Gene
Suggested Antigen Peptide Sequences for MTOR Gene
Graphical View of Domain Structure for InterPro Entry
P42345UniProtKB/Swiss-Prot:
MTOR_HUMAN :- The kinase domain (PI3K/PI4K) is intrinsically active but has a highly restricted catalytic center.
- Belongs to the PI3/PI4-kinase family.
- Domain:
-
- The kinase domain (PI3K/PI4K) is intrinsically active but has a highly restricted catalytic center.
- The FAT domain forms three discontinuous subdomains of alpha-helical TPR repeats plus a single subdomain of HEAT repeats. The four domains pack sequentially to form a C-shaped a-solenoid that clamps onto the kinase domain (PubMed:23636326).
- Family:
-
- Belongs to the PI3/PI4-kinase family.
Function for MTOR Gene
Molecular function for MTOR Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activation of mTORC1 by growth factors such as insulin involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase a potent activator of the protein kinase activity of mTORC1. Insulin-stimulated and amino acid-dependent phosphorylation at Ser-1261 promotes autophosphorylation and the activation of mTORC1. Activation by amino acids requires relocalization of the mTORC1 complex to lysosomes that is mediated by the Ragulator complex, SLC38A9, and the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD (PubMed:18497260, PubMed:20381137, PubMed:25561175, PubMed:25567906). On the other hand, low cellular energy levels can inhibit mTORC1 through activation of PRKAA1 while hypoxia inhibits mTORC1 through a REDD1-dependent mechanism which may also require PRKAA1. The kinase activity of MTOR within the mTORC1 complex is positively regulated by MLST8 and negatively regulated by DEPTOR and AKT1S1. MTOR phosphorylates RPTOR which in turn inhibits mTORC1. MTOR is the target of the immunosuppressive and anti-cancer drug rapamycin which acts in complex with FKBP1A/FKBP12, and specifically inhibits its kinase activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. It may be regulated by RHEB but in an indirect manner through the PI3K signaling pathway.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at Ser-758, disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at Ser-473 of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at Ser-422 (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity).
Enzyme Numbers (IUBMB) for MTOR Gene
Phenotypes From GWAS Catalog for MTOR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0001030 | RNA polymerase III type 1 promoter DNA binding | IDA | 20233713 |
| GO:0001031 | RNA polymerase III type 2 promoter DNA binding | IDA | 20233713 |
| GO:0001032 | RNA polymerase III type 3 promoter DNA binding | IDA | 20233713 |
| GO:0001156 | TFIIIC-class transcription factor binding | IDA | 20543138 |
Phenotypes for MTOR Gene
- MGI mutant phenotypes for MTOR:
-
inferred from 16 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- endocrine/exocrine gland phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for MTOR:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Decreased ionizing radiation sensitivity
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Transferrin accumulation in the perinuclear area
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased substrate adherent cell growth
- Decreased shRNA abundance (Z-score < -2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Decreased shRNA abundance
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased circadian period length
- Decreased cell number
- Decreased cell proliferation
- Increased cell migration
- Increased Nanog expression
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
- Decreased viability with paclitaxel
Animal Models for MTOR Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for MTOR
- Cyagen custom Knockout/knockin (KOKI) mouse models for MTOR
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MTOR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTOR gene
- Search ViGene Biosciences for MTOR
CRISPR Products
-
OriGene CRISPR knockouts for MTOR
- genomics-online: gRNA clones - Search results for 69 available MTOR gene related products
- Overview of 69 available MTOR gene related products
- Applied Biological Materials CRISPR for MTOR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTOR
- GenScript: Design CRISPR guide RNA sequences for MTOR
miRNA for MTOR Gene
- miRTarBase miRNAs that target MTOR
-
- hsa-mir-99a-5p (MIRT006146)
- hsa-mir-520c-3p (MIRT006155)
- hsa-mir-373-3p (MIRT006157)
- hsa-mir-99b-5p (MIRT006564)
- hsa-mir-144-3p (MIRT006872)
- hsa-mir-100-5p (MIRT007365)
- hsa-mir-199a-3p (MIRT026023)
- hsa-mir-16-5p (MIRT031485)
- hsa-mir-744-5p (MIRT037492)
- hsa-mir-181b-5p (MIRT047241)
- hsa-mir-101-3p (MIRT054040)
- hsa-let-7c-5p (MIRT437347)
- hsa-mir-218-5p (MIRT440200)
- hsa-mir-496 (MIRT732906)
- hsa-mir-196b-5p (MIRT733142)
- hsa-mir-224-5p (MIRT733173)
- hsa-mir-128-3p (MIRT733518)
- hsa-mir-193a-5p (MIRT734058)
- hsa-mir-125a-5p (MIRT734303)
- hsa-mir-497-5p (MIRT734576)
- hsa-mir-3188 (MIRT734711)
- rno-mir-96-5p (MIRT735496)
miRNA Products
- Search ViGene Biosciences for MTOR
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for MTOR
- Browse OriGene Inhibitory RNA Products For MTOR
- genomics-online: shRNA clones - Search results for 69 available MTOR gene related products
- Overview of 69 available MTOR gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MTOR gene
Clone Products
- Sino Biological Human cDNA Clone for MTOR
- VectorBuilder custom plasmid, inducible vectors for MTOR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTOR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MTOR
- Applied Biological Materials Clones for MTOR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MTOR
-
ViGene Biosciences adenoviral particle packaged cDNA for MTOR gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MTOR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTOR gene
No data available for Transcription Factor Targets and HOMER Transcription for MTOR Gene
Localization for MTOR Gene
Subcellular locations from UniProtKB/Swiss-Prot for MTOR Gene
- Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Cytoplasm. Nucleus, PML body. Microsome membrane. Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137). {ECO:0000250 UniProtKB:Q9JLN9, ECO:0000269 PubMed:18497260, ECO:0000269 PubMed:20381137}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| lysosome | 5 |
| plasma membrane | 4 |
| mitochondrion | 4 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| endosome | 2 |
| peroxisome | 1 |
- Cytosol (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005634 | nucleus | IBA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 11853878 |
| GO:0005739 | mitochondrion | IEA | -- |
Pathways & Interactions for MTOR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | Regulation of lipid metabolism Insulin signaling-generic cascades | ||
| 3 | mTOR signalling |
.70
|
.51
|
| 4 | Endometrial cancer |
.52
|
.32
|
| 5 | PI3K/AKT activation |
.89
|
|
Pathways by source for MTOR Gene
5 Sino Biological pathways for MTOR Gene
2 GeneTex pathways for MTOR Gene
47 BioSystems pathways for MTOR Gene
51 Reactome pathways for MTOR Gene
2 PharmGKB pathways for MTOR Gene
35 KEGG pathways for MTOR Gene
14 GeneGo (Thomson Reuters) pathways for MTOR Gene
- Development CNTF receptor signaling
- Development Endothelin-1/EDNRA transactivation of EGFR
- Development Growth hormone signaling via PI3K/AKT and MAPK cascades
- Development IGF-1 receptor signaling
- Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
8 R&D Systems pathways for MTOR Gene
4 Tocris pathways for MTOR Gene
18 Qiagen pathways for MTOR Gene
1 Cell Signaling Technology pathway for MTOR Gene
Interacting Proteins for MTOR Gene
Selected Interacting proteins:
ENSP00000354558
P42345-MTOR_HUMAN
for MTOR Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for MTOR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | IDA | 18762023 |
| GO:0001932 | regulation of protein phosphorylation | IEA | -- |
| GO:0001933 | negative regulation of protein phosphorylation | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IEA,IDA | 20233713 |
| GO:0001938 | positive regulation of endothelial cell proliferation | IEA | -- |
Drugs & Compounds for MTOR Gene
(112) Drugs for MTOR Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Everolimus | Approved | Pharma | Target, inhibitor, Biomarker | mTOR inhibitor, mTOR Inhibitors, Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors | 2011 | |
| Temsirolimus | Approved | Pharma | Target, inhibitor, Inhibition, Biomarker | MTOR inhibitor, mTOR inhibitor; antitumor, mTOR inhibitor, mTOR Inhibitors, Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors | 0 | |
| Sirolimus | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors | 2011 | |
| Pimecrolimus | Approved, Investigational | Pharma | Target, potentiator, inhibitor | 64 | ||
| Miconazole | Approved, Investigational, Vet_approved | Pharma | Antagonist, Pore Blocker | 3838 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| WYE 687 dihydrochloride |
|
1062161-90-3 |
|
|
(4) Tocris Compounds for MTOR Gene
| Compound | Action | Cas Number |
|---|---|---|
| Rapamycin | mTOR inhibitor; immunosuppressant | 53123-88-9 |
| Temsirolimus | mTOR inhibitor; antitumor | 162635-04-3 |
| Torin 1 | Potent and selective mTOR inhibitor | 1222998-36-8 |
| WYE 687 dihydrochloride | Potent and selective mTOR inhibitor | 1062161-90-3 |
(37) ApexBio Compounds for MTOR Gene
| Compound | Action | Cas Number |
|---|---|---|
| AZD2014 | Novel mTOR inhibitor | 1009298-59-2 |
| AZD8055 | MTOR inhibitor | 1009298-09-2 |
| BEZ235 (NVP-BEZ235) | PI3K/mTOR inhibitor,ATP-competitve | 915019-65-7 |
| BEZ235 Tosylate | MTOR/P13K inhibitor | 1028385-32-1 |
| Everolimus (RAD001) | MTOR inhibitor | 159351-69-6 |
| GDC-0349 | MTOR inhibitor | 1207360-89-1 |
| GDC-0980 (RG7422) | Class I PI3K inhibitor for PI3Kα/β/δ/γ | 1032754-93-0 |
| GDC-mTOR inhibitor | MTOR inhibitor | 1207358-59-5 |
| GNE-477 | dual PI3K/mTOR inhibitor | 1032754-81-6 |
| GNE-493 | Pan-PI3K/mTOR inhibitor | 1033735-94-2 |
| GSK1059615 | PI3K and mTOR inhibitor,potent and reversible | 958852-01-2 |
| GSK2126458 | PI3K/mTOR inhibitor | 1086062-66-9 |
| INK 128 (MLN0128) | MTOR(TORC-1/-2) inhibitor,potent and selective | 1224844-38-5 |
| KU-0063794 | MTORC1 and mTORC2 inhibitor | 938440-64-3 |
| LY 303511 | MTOR inhibitor | 154447-38-8 |
| MHY1485 | mTOR activator, autophage inhibitor | 326914-06-1 |
| Nordihydroguaiaretic acid | Anti-tumor agent;lipoxygenase inhibitor | 500-38-9 |
| NVP-BGT226 | PI3K/mTOR inhibitor,selective and novel | 1245537-68-1 |
| OSI-027 | MTORC1/ mTORC2 inhibitor | 936890-98-1 |
| Palomid 529 | PI3K/Akt/mTOR inhibitor | 914913-88-5 |
| PF-04691502 | PI3K/mTOR (FRAP) inhibitor | 1013101-36-4 |
| PF-05212384 (PKI-587) | PI3Kα, PI3Kγ and mTOR inhibitor | 1197160-78-3 |
| PI-103 | Class I PI3K, mTOR and DNA-PK inhibitor | 371935-74-9 |
| PP121 | Dual inhibitor of tyrosine and phosphoinositide kinases | 1092788-83-4 |
| PP242 | MTOR inhibitor, selective and ATP-competitive | 1092351-67-1 |
| Rapamycin (Sirolimus) | Original antifungal antibiotic | 53123-88-9 |
| Ridaforolimus (Deforolimus, MK-8669) | MTOR inhibitor | 572924-54-0 |
| SAR245409 (XL765) | mTOR/PI3K inhibitor | 1349796-36-6 |
| Temsirolimus | MTOR inhibitor | 162635-04-3 |
| Torin 1 | MTOR inhibitor,potent and selective | 1222998-36-8 |
| Torin 2 | MTOR inhibitor,highly potent and selective | 1223001-51-1 |
| VS-5584 (SB2343) | MTOR/P13K inhibitor,potent and selective | 1246560-33-7 |
| WAY-600 | MTOR inhibitor | 1062159-35-6 |
| WYE-125132 (WYE-132) | ATP-competitive mTOR inhibitor, highly potent | 1144068-46-1 |
| WYE-354 | MTOR inhibitor,potent,ATP-competitive and cell-permeable | 1062169-56-5 |
| WYE-687 | MTOR inhibitor,ATP-competitive and selective | 1062161-90-3 |
| XL388 | MTOR inhibitor,highly potent and selective | 1251156-08-7 |
Transcripts for MTOR Gene
mRNA/cDNA for MTOR Gene
- (6) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (260) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MTOR Gene
CRISPR Products
-
OriGene CRISPR knockouts for MTOR
- genomics-online: gRNA clones - Search results for 69 available MTOR gene related products
- Overview of 69 available MTOR gene related products
- Applied Biological Materials CRISPR for MTOR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTOR
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miRNA Products
- Search ViGene Biosciences for MTOR
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for MTOR
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- genomics-online: shRNA clones - Search results for 69 available MTOR gene related products
- Overview of 69 available MTOR gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MTOR gene
Clone Products
- Sino Biological Human cDNA Clone for MTOR
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MTOR
- Applied Biological Materials Clones for MTOR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP5: |
Expression for MTOR Gene
This gene is overexpressed in Nasal epithelium (32.3) and Bone (23.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTOR Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MTOR Gene:
MTORSOURCE GeneReport for Unigene cluster for MTOR Gene:
Hs.338207mRNA Expression by UniProt/SwissProt for MTOR Gene:
P42345-MTOR_HUMAN
Tissue specificity:
Expressed in numerous tissues, with highest levels in testis.
Evidence on tissue expression from TISSUES for MTOR Gene
- Nervous system(4.9)
- Liver(4.7)
- Skin(3.8)
- Blood(3.7)
- Muscle(3.4)
- Kidney(3.2)
- Heart(3)
- Intestine(2.9)
- Lung(2.8)
- Eye(2.7)
- Pancreas(2.5)
- Lymph node(2.4)
- Bone marrow(2.2)
- Spleen(2.2)
- Thyroid gland(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MTOR Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
Regions:
Head and neck:
- brain
- cranial nerve
- head
General:
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for MTOR
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MTOR Gene
Orthologs for MTOR Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MTOR 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MTOR 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | MTOR 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MTOR 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mtor 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Mtor 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | MTOR 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MTOR 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mtor 33 |
|
||
| Str.15506 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.9731 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mtor 33 34 |
|
||
| wufc22h08 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3686 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Tor 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007873 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | let-363 34 |
|
ManyToMany | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR420W 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B13948g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TOR2 33 34 |
|
||
| TOR1 36 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | TOR 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.11338 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os05g0235300 33 |
|
||
| Os.17756 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.1352 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.7658 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU05608 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tor2 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4144 33 |
|
- Species where no ortholog for MTOR was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for MTOR Gene
(3) SIMAP similar genes for MTOR Gene using alignment to 3 proteins:
No data available for Paralogs for MTOR Gene
Variants for MTOR Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057519777 | likely-pathogenic, Kidney Carcinoma | 11,109,304(-) | C/G | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs1057519778 | likely-pathogenic, Kidney Carcinoma | 11,122,122(-) | G/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs1057519779 | likely-pathogenic, pathogenic, Kidney Carcinoma, Focal cortical dysplasia type II | 11,157,242(-) | A/G | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs1057519780 | likely-pathogenic, Transitional cell carcinoma of the bladder | 11,127,800(-) | C/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs1057519870 | not-provided, Malignant melanoma | 11,128,462(-) | G/A | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2658000 | CNV | deletion | 23128226 |
| esv3303581 | CNV | mobile element insertion | 20981092 |
| esv3427172 | CNV | insertion | 20981092 |
| esv3585215 | CNV | loss | 21293372 |
| nsv1122297 | CNV | deletion | 24896259 |
| nsv474152 | CNV | novel sequence insertion | 20440878 |
| nsv545407 | CNV | gain | 21841781 |
| nsv945769 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
0.0904% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.15;
39.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MTOR Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTOR Gene
Disorders for MTOR Gene
(70) MalaCards diseases for MTOR Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| smith-kingsmore syndrome |
|
|
| focal cortical dysplasia, type ii |
|
|
| luminal breast carcinoma |
|
|
| tuberous sclerosis |
|
|
| glioblastoma multiforme |
|
Search MTOR in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MTOR_HUMAN- Focal cortical dysplasia 2 (FCORD2) [MIM:607341]: A form of focal cortical dysplasia, a malformation of cortical development that results in medically refractory epilepsy in the pediatric population and in adults. FCORD2 is a severe form, with onset usually in childhood, characterized by disrupted cortical lamination and specific cytological abnormalities. It is classified in 2 subtypes: type IIA characterized by dysmorphic neurons and lack of balloon cells; type IIB with dysmorphic neurons and balloon cells. {ECO:0000269 PubMed:25799227, ECO:0000269 PubMed:25878179, ECO:0000269 PubMed:26018084, ECO:0000269 PubMed:27830187}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Smith-Kingsmore syndrome (SKS) [MIM:616638]: An autosomal dominant syndrome characterized by intellectual disability, macrocephaly, seizures, umbilical hernia, and facial dysmorphic features. {ECO:0000269 PubMed:25851998, ECO:0000269 PubMed:26542245, ECO:0000269 PubMed:27830187}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MTOR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for MTOR Gene
Publications for MTOR Gene
- A mammalian protein targeted by G1-arresting rapamycin-receptor complex. (PMID: 8008069) Brown EJ … Schreiber SL (Nature 1994) 2 3 4 22 58
- Dissecting the role of mTOR: lessons from mTOR inhibitors. (PMID: 20005306) Dowling RJ … Sonenberg N (Biochimica et biophysica acta 2010) 3 22 25 58
- Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. (PMID: 19487463) Acosta-Jaquez HA … Fingar DC (Molecular and cellular biology 2009) 3 4 22 58
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). (PMID: 18925875) García-Martínez JM … Alessi DR (The Biochemical journal 2008) 3 4 22 58
- GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. (PMID: 12718876) Kim DH … Sabatini DM (Molecular cell 2003) 3 4 22 58
Products for MTOR Gene
- R&D Systems Antibodies for MTOR (TOR)
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- TA300537
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- CF806117
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MTOR
- antibodies-online: Search results for 376 available MTOR Antibodies ranked by validation data