Aliases for MTNR1B Gene
External Ids for MTNR1B Gene
Previous GeneCards Identifiers for MTNR1B Gene
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]
GeneCards Summary for MTNR1B Gene
MTNR1B (Melatonin Receptor 1B) is a Protein Coding gene. Diseases associated with MTNR1B include Type 2 Diabetes Mellitus and Idiopathic Scoliosis. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and melatonin receptor activity. An important paralog of this gene is MTNR1A.
UniProtKB/Swiss-Prot Summary for MTNR1B Gene
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Melatonin receptors are a group of high affinity Gi/G0 protein-coupled receptors, which are split into two subtypes; MT1 and MT2. They are widely distributed with high concentrations found in the brain (especially in the suprachiasmatic nucleus) and in the retina.