Aliases for MTNR1A Gene
External Ids for MTNR1A Gene
Previous GeneCards Identifiers for MTNR1A Gene
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
GeneCards Summary for MTNR1A Gene
MTNR1A (Melatonin Receptor 1A) is a Protein Coding gene. Diseases associated with MTNR1A include Delayed Sleep Phase Disorder and Periodic Limb Movement Disorder. Among its related pathways are Signaling by GPCR and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and melatonin receptor activity. An important paralog of this gene is MTNR1B.
UniProtKB/Swiss-Prot Summary for MTNR1A Gene
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Melatonin receptors are a group of high affinity Gi/G0 protein-coupled receptors, which are split into two subtypes; MT1 and MT2. They are widely distributed with high concentrations found in the brain (especially in the suprachiasmatic nucleus) and in the retina.