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Aliases for MTMR4 Gene
Aliases for MTMR4 Gene
External Ids for MTMR4 Gene
- HGNC: 7452
- Entrez Gene: 9110
- Ensembl: ENSG00000108389
- OMIM: 603559
- UniProtKB: Q9NYA4
Previous GeneCards Identifiers for MTMR4 Gene
- GC17M056311
- GC17M059048
- GC17M056908
- GC17M057041
- GC17M053921
- GC17M056566
- GC17M051927
Summaries for MTMR4 Gene
GeneCards Summary for MTMR4 Gene
MTMR4 (Myotubularin Related Protein 4) is a Protein Coding gene. Diseases associated with MTMR4 include Mulibrey Nanism and Myopathy, Centronuclear, X-Linked. Among its related pathways are Signaling by GPCR and Inositol phosphate metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein serine/threonine phosphatase activity. An important paralog of this gene is MTMR3.
UniProtKB/Swiss-Prot Summary for MTMR4 Gene
-
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
Additional gene information for MTMR4 Gene
- HGNC(7452)
- Entrez Gene(9110)
- Ensembl(ENSG00000108389)
- OMIM(603559)
- UniProtKB(Q9NYA4)
- Open Targets Platform(ENSG00000108389)
- Monarch Initiative
- Search for MTMR4 at DataMed
- Search for MTMR4 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MTMR4 Gene
Genomics for MTMR4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MTMR4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MTMR4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MTMR4
- Top Transcription factor binding sites by QIAGEN in the MTMR4 gene promoter:
-
- C/EBPalpha
- CREB
- deltaCREB
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- Lmo2
Genomic Locations for MTMR4 Gene
Genomic Locations for MTMR4 Gene
- chr17:58,489,529-58,518,109
- (GRCh38/hg38)
- Size:
- 28,581 bases
- Orientation:
- Minus strand
- chr17:56,566,893-56,595,266
- (GRCh37/hg19)
- Size:
- 28,374 bases
- Orientation:
- Minus strand
Genomic View for MTMR4 Gene
Genes around MTMR4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q22 by HGNC
- 17q22 by Entrez Gene
- 17q22 by Ensembl
MTMR4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MTMR4 Gene
Proteins for MTMR4 Gene
-
Protein details for MTMR4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NYA4-MTMR4_HUMAN
- Recommended name:
- Myotubularin-related protein 4
- Protein Accession:
- Q9NYA4
- D3DTZ6
- Q8IV27
- Q9Y4D5
Protein attributes for MTMR4 Gene
- Size:
- 1195 amino acids
- Molecular mass:
- 133353 Da
- Quaternary structure:
- No Data Available
Protein Expression for MTMR4 Gene
Selected DME Specific Peptides for MTMR4 Gene
- Q9NYA4:
-
- HCSDGWDRT
- FMGMANIH
- PQKLLILDARSY
Post-translational modifications for MTMR4 Gene
Other Protein References for MTMR4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MTMR4
- Novus Biologicals Antibodies for MTMR4
-
Abcam antibodies for MTMR4
- Invitrogen Antibodies for MTMR4 (AFLGC-MTMR4)
-
Boster Bio Antibodies for MTMR4
-
Santa Cruz Biotechnology (SCBT) Antibodies for MTMR4
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MTMR4
- Origene Custom Protein Services for MTMR4
- Novus Biologicals lysates for MTMR4
-
Signalway Proteins for MTMR4
Assay Products
Domains & Families for MTMR4 Gene
Gene Families for MTMR4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for MTMR4 Gene
- InterPro:
- Blocks:
-
- Zn-finger, FYVE type
- Myotubularin-related
- ProtoNet:
Suggested Antigen Peptide Sequences for MTMR4 Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc finger FYVE domain-containing protein 11 (MTMR4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NYA4UniProtKB/Swiss-Prot:
MTMR4_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Function for MTMR4 Gene
Molecular function for MTMR4 Gene
- UniProtKB/Swiss-Prot Function:
- Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
- GENATLAS Biochemistry:
- myotubularin related protein 4 ,expressed in brain,related to KIAA0371 putative hyposine phosphatase family
Enzyme Numbers (IUBMB) for MTMR4 Gene
Phenotypes From GWAS Catalog for MTMR4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004438 | phosphatidylinositol-3-phosphatase activity | IBA | 21873635 |
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004722 | protein serine/threonine phosphatase activity | IEA,TAS | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 20061380 |
Phenotypes for MTMR4 Gene
- MGI mutant phenotypes for MTMR4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MTMR4:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Decreased cell migration
- Increased transferrin (TF) endocytosis
- Increased epidermal growth factor receptor (EGFR) surface abundance
- Increased replication of vaccinia virus (VACV)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs
Animal Models for MTMR4 Gene
- MGI Knock Outs for MTMR4:
-
- Mtmr4 Mtmr4<tm1a(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MTMR4 - Select products 50% OFF >
- * MTMR4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MTMR4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MTMR4
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTMR4
miRNA for MTMR4 Gene
- miRTarBase miRNAs that target MTMR4
-
- mmu-miR-301b-3p (MIRT007890)
- mmu-miR-223-3p (MIRT009629)
- mmu-miR-324-3p (MIRT010826)
- mmu-miR-15a-5p (MIRT011677)
- mmu-let-7b-5p (MIRT012076)
- mmu-miR-9-5p (MIRT015233)
- hsa-miR-130b-3p (MIRT020319)
- hsa-miR-103a-3p (MIRT027212)
- hsa-miR-193b-3p (MIRT041608)
- hsa-miR-125b-5p (MIRT046004)
- hsa-miR-376a-5p (MIRT440202)
- hsa-miR-136-5p (MIRT440203)
- hsa-miR-218-5p (MIRT440204)
- hsa-miR-6808-3p (MIRT472787)
- hsa-miR-7848-3p (MIRT472788)
- hsa-miR-3653-3p (MIRT472789)
- hsa-miR-124-5p (MIRT472790)
- hsa-miR-7973 (MIRT472791)
- hsa-miR-7114-3p (MIRT472792)
- hsa-miR-1180-5p (MIRT472793)
- hsa-miR-6513-3p (MIRT472794)
- hsa-miR-4761-5p (MIRT472795)
- hsa-miR-4501 (MIRT472796)
- hsa-miR-4255 (MIRT472797)
- hsa-miR-3908 (MIRT472798)
- hsa-miR-1912 (MIRT472799)
- hsa-miR-1295b-5p (MIRT472800)
- hsa-miR-8066 (MIRT472802)
- mmu-miR-136-5p (MIRT606646)
- hsa-miR-16-5p (MIRT727134)
- hsa-miR-195-5p (MIRT727135)
- hsa-miR-15b-5p (MIRT727136)
- hsa-miR-15a-5p (MIRT727137)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MTMR4
- Browse OriGene Inhibitory RNA Products For MTMR4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTMR4
Clone Products
- Applied Biological Materials (abm): Clones for MTMR4 - Select products 50% OFF >
- * MTMR4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MTMR4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MTMR4
Cell Line Products
-
Horizon Cell Lines for MTMR4
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTMR4 Gene
Localization for MTMR4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MTMR4 Gene
- Cytoplasm. Membrane. Peripheral membrane protein. Note=Localized to perinuclear region.
| Compartment | Confidence |
|---|---|
| endosome | 5 |
| cytosol | 5 |
| extracellular | 4 |
| cytoskeleton | 2 |
| nucleus | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 22664934 |
| GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
| GO:0005768 | endosome | IDA | 16787938 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA,IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTMR4 Gene
Pathways & Interactions for MTMR4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.40
|
|
| 2 | PI Metabolism |
.63
|
|
| 3 | Inositol phosphate metabolism (KEGG) | ||
| 4 | TGF-beta receptor signaling activates SMADs | ||
| 5 | Autophagy - animal | ||
Pathways by source for MTMR4 Gene
10 Reactome pathways for MTMR4 Gene
4 KEGG pathways for MTMR4 Gene
Interacting Proteins for MTMR4 Gene
Selected Interacting proteins:
Q9NYA4-MTMR4_HUMAN
ENSP00000325285
for MTMR4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MTMR4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IEA,TAS | 9736772 |
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | -- |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IEA | -- |
| GO:0010506 | regulation of autophagy | IBA | 21873635 |
| GO:0014894 | response to denervation involved in regulation of muscle adaptation | IEA | -- |
Drugs & Compounds for MTMR4 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14066-19-4, 14265-44-2 |
|
Transcripts for MTMR4 Gene
mRNA/cDNA for MTMR4 Gene
- 3 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000323456 5839 nts (view in UCSC)
- ENST00000578259 588 nts (view in UCSC)
- ENST00000579921 425 nts (view in UCSC)
- ENST00000579925 5622 nts (view in UCSC)
- ENST00000580983 631 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MTMR4 - Select products 50% OFF >
- * MTMR4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MTMR4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MTMR4
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTMR4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MTMR4
- Browse OriGene Inhibitory RNA Products For MTMR4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTMR4
Clone Products
- Applied Biological Materials (abm): Clones for MTMR4 - Select products 50% OFF >
- * MTMR4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MTMR4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MTMR4
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 19b | · | 19c | · | 19d |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: |
Relevant External Links for MTMR4 Gene
- GeneLoc Exon Structure for
- MTMR4
Expression for MTMR4 Gene
This gene is overexpressed in Pancreas (42.7), Monocytes (11.2), and Platelet (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MTMR4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MTMR4
SOURCE GeneReport for Unigene cluster for MTMR4 Gene:
Hs.514373mRNA Expression by UniProt/SwissProt for MTMR4 Gene:
Q9NYA4-MTMR4_HUMAN
Tissue specificity:
Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.
Evidence on tissue expression from TISSUES for MTMR4 Gene
- Nervous system(4.8)
- Liver(4.4)
- Lung(4.3)
Primer Products
-
OriGene qPCR primer pairs for MTMR4
-
OriGene qPCR primer pairs and template standards for MTMR4
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTMR4 Gene
Orthologs for MTMR4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MTMR4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MTMR4 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mtmr4 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mtmr4 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MTMR4 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MTMR4 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MTMR4 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MTMR4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MTMR4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mtmr4 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:63645 30 |
|
||
| MTMR4 31 |
|
OneToOne | |||
| zgc63645 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG3632 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | T24A11.1a 32 |
|
|
|
| T24A11.1b 32 |
|
|
- Species where no ortholog for MTMR4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MTMR4 Gene
- ENSEMBL:
- Gene Tree for MTMR4 (if available)
- TreeFam:
- Gene Tree for MTMR4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MTMR4: view image
Paralogs for MTMR4 Gene
Paralogs for MTMR4 Gene
(9) SIMAP similar genes for MTMR4 Gene using alignment to 7 proteins:
- MTMR4_HUMAN
- J3KT95_HUMAN
- J3QKV8_HUMAN
- J3QLB9_HUMAN
- J3QR65_HUMAN
- J3QRJ2_HUMAN
- J3QS98_HUMAN
Variants for MTMR4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MTMR4 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 779457 | Benign: not provided | 58,495,103(-) | T/A | SYNONYMOUS_VARIANT | |
| 779458 | Benign: not provided | 58,508,178(-) | A/G | SYNONYMOUS_VARIANT | |
| 779459 | Benign: not provided | 58,508,751(-) | A/G | SYNONYMOUS_VARIANT | |
| rs2302189 | - | p.Val297Gly | |||
| rs2302190 | - | p.Ser280Gly |
Residual Variation Intolerance Score:
16.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
21.98;
99.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MTMR4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MTMR4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MTMR4 Gene
Disorders for MTMR4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mulibrey nanism |
|
|
| myopathy, centronuclear, x-linked |
|
|
| hydranencephaly |
|
|
| centronuclear myopathy |
|
|
Search MTMR4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MTMR4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MTMR4 Gene
Publications for MTMR4 Gene
- Phosphoinositide cycle gene polymorphisms affect the plasma lipid profile in the Quebec Family Study. (PMID: 19329342) Dolley G … Vohl MC (Molecular genetics and metabolism 2009) 3 23 41
- Genome-wide association scan for childhood caries implicates novel genes. (PMID: 21940522) Shaffer JR … Marazita ML (Journal of dental research 2011) 3 41
- MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes. (PMID: 20061380) Yu J … Tang H (The Journal of biological chemistry 2010) 3 23
- The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. (PMID: 19125695) Plant PJ … Batt J (The Biochemical journal 2009) 3 23
- FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate. (PMID: 11302699) Zhao R … Zhao ZJ (Experimental cell research 2001) 3 4
ExternalLinks
Products for MTMR4 Gene
- Custom Antibody ServicesOriGene Antibodies for MTMR4
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MTMR4
- Origene Custom Protein Services for MTMR4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MTMR4
- Browse OriGene Inhibitory RNA Products For MTMR4
- OriGene qPCR primer pairs for MTMR4
- OriGene qPCR primer pairs and template standards for MTMR4
- OriGene CRISPR knockouts for MTMR4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MTMR4
- Sino Biological Human cDNA Clone for MTMR4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MTMR4
- Novus Biologicals lysates for MTMR4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MTMR4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for MTMR4 (AFLGC-MTMR4)
- VectorBuilder Custom and pre-made DNA vectors for MTMR4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MTMR4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MTMR4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MTMR4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MTMR4
- antibodies-online: Show 21 available MTMR4 Antibodies ranked by validation data
- Compare Top MTMR4 Antibodies
- antibodies-online: Search results for available MTMR4 related products ranked by validation data
- antibodies-online: Search results for available MTMR4 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for MTMR4
- Search Santa Cruz Biotechnology (SCBT) for MTMR4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MTMR4
- Horizon Cell Lines for MTMR4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MTMR4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MTMR4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MTMR4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTMR4
- Boster Bio Antibodies for MTMR4
- Browse Boster Bio ELISA Kits
Sources for MTMR4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB