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Aliases for MTMR4 Gene

Aliases for MTMR4 Gene

  • Myotubularin Related Protein 4 2 3 5
  • FYVE Domain-Containing Dual Specificity Protein Phosphatase 2 3 4
  • Zinc Finger FYVE Domain-Containing Protein 11 3 4
  • FYVE-DSP2 3 4
  • ZFYVE11 3 4
  • Zinc Finger, FYVE Domain Containing 11 3
  • Myotubularin-Related Protein 4 3
  • EC 4
  • KIAA0647 4

External Ids for MTMR4 Gene

Previous GeneCards Identifiers for MTMR4 Gene

  • GC17M056311
  • GC17M059048
  • GC17M056908
  • GC17M057041
  • GC17M053921
  • GC17M056566
  • GC17M051927

Summaries for MTMR4 Gene

GeneCards Summary for MTMR4 Gene

MTMR4 (Myotubularin Related Protein 4) is a Protein Coding gene. Among its related pathways are Metabolism and superpathway of inositol phosphate compounds. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein serine/threonine phosphatase activity. An important paralog of this gene is MTMR3.

UniProtKB/Swiss-Prot for MTMR4 Gene

  • Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).

Additional gene information for MTMR4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTMR4 Gene

Genomics for MTMR4 Gene

GeneHancer (GH) Regulatory Elements for MTMR4 Gene

Promoters and enhancers for MTMR4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J058511 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.9 1894 8.9 ZFP64 YBX1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 MTMR4 TRIM37 RAD51C SRSF1 MKS1 HSF5 VEZF1 SEPT4 C17orf47 SMG8
GH17J058630 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 10.8 -113.8 -113771 2.6 MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ENSG00000212195 LOC105371842 GC17M058632 SRSF1 MKS1 TRIM37 DHX40 RAD51C SMG8 VEZF1
GH17J058491 Enhancer 1 ENCODE 11.1 +25.4 25436 1.9 HDGF PKNOX1 ATF1 ARNT SIN3A TCF12 ZNF766 GATA2 FOS ATF7 RNF43 MTMR4 PIR59993
GH17J058991 Enhancer 1 Ensembl ENCODE 10.4 -474.6 -474576 3.1 FOXA2 ZNF133 BATF IRF4 RAD21 YY1 EGR1 SCRT2 ATF7 FOS PPM1E MTMR4 ENSG00000212195 GC17P058985 GC17M059024 TRIM37
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MTMR4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MTMR4 gene promoter:
  • E2F-2
  • E2F
  • E2F-1
  • Lmo2
  • E2F-3a
  • E2F-4
  • E2F-5
  • CREB
  • deltaCREB
  • C/EBPalpha

Genomic Locations for MTMR4 Gene

Genomic Locations for MTMR4 Gene
28,582 bases
Minus strand
28,374 bases
Minus strand

Genomic View for MTMR4 Gene

Genes around MTMR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTMR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTMR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTMR4 Gene

Proteins for MTMR4 Gene

  • Protein details for MTMR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myotubularin-related protein 4
    Protein Accession:
    Secondary Accessions:
    • D3DTZ6
    • Q8IV27
    • Q9Y4D5

    Protein attributes for MTMR4 Gene

    1195 amino acids
    Molecular mass:
    133353 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTMR4 Gene

Post-translational modifications for MTMR4 Gene

  • Ubiquitination at Lys257 and isoforms=202
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MTMR4 Gene

Domains & Families for MTMR4 Gene

Gene Families for MTMR4 Gene

Suggested Antigen Peptide Sequences for MTMR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
genes like me logo Genes that share domains with MTMR4: view

Function for MTMR4 Gene

Molecular function for MTMR4 Gene

UniProtKB/Swiss-Prot Function:
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
GENATLAS Biochemistry:
myotubularin related protein 4 ,expressed in brain,related to KIAA0371 putative hyposine phosphatase family

Enzyme Numbers (IUBMB) for MTMR4 Gene

Phenotypes From GWAS Catalog for MTMR4 Gene

Gene Ontology (GO) - Molecular Function for MTMR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004438 phosphatidylinositol-3-phosphatase activity TAS --
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity TAS,IEA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 20061380
genes like me logo Genes that share ontologies with MTMR4: view
genes like me logo Genes that share phenotypes with MTMR4: view

Animal Models for MTMR4 Gene

MGI Knock Outs for MTMR4:
  • Mtmr4 Mtmr4<tm1a(EUCOMM)Wtsi>

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTMR4 Gene

Localization for MTMR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTMR4 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTMR4 gene
Compartment Confidence
extracellular 5
cytosol 5
endosome 5
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MTMR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IDA 16787938
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MTMR4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTMR4 Gene

Pathways & Interactions for MTMR4 Gene

genes like me logo Genes that share pathways with MTMR4: view

SIGNOR curated interactions for MTMR4 Gene


Gene Ontology (GO) - Biological Process for MTMR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,TAS 9736772
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway IEA --
GO:0014894 response to denervation involved in regulation of muscle adaptation IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with MTMR4: view

Drugs & Compounds for MTMR4 Gene

(2) Drugs for MTMR4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for MTMR4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
genes like me logo Genes that share compounds with MTMR4: view

Transcripts for MTMR4 Gene

Unigene Clusters for MTMR4 Gene

Myotubularin related protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTMR4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a ·
SP1: - - -
SP2: -
SP3: - - - - - - - - - - - - - - - - - - - -
SP5: -

ExUns: 19b · 19c · 19d

Relevant External Links for MTMR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTMR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTMR4 Gene

Protein differential expression in normal tissues from HIPED for MTMR4 Gene

This gene is overexpressed in Pancreas (42.7), Monocytes (11.2), and Platelet (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MTMR4 Gene

Protein tissue co-expression partners for MTMR4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTMR4 Gene:


SOURCE GeneReport for Unigene cluster for MTMR4 Gene:


mRNA Expression by UniProt/SwissProt for MTMR4 Gene:

Tissue specificity: Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.

Evidence on tissue expression from TISSUES for MTMR4 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with MTMR4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTMR4 Gene

Orthologs for MTMR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTMR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTMR4 34 33
  • 99.58 (n)
(Canis familiaris)
Mammalia MTMR4 34 33
  • 92.13 (n)
(Rattus norvegicus)
Mammalia Mtmr4 33
  • 89.37 (n)
(Mus musculus)
Mammalia Mtmr4 16 34 33
  • 89.32 (n)
(Bos Taurus)
Mammalia MTMR4 34 33
  • 87.56 (n)
(Monodelphis domestica)
Mammalia MTMR4 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia MTMR4 34
  • 73 (a)
(Gallus gallus)
Aves MTMR4 34 33
  • 73.22 (n)
(Anolis carolinensis)
Reptilia MTMR4 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtmr4 33
  • 70.01 (n)
(Danio rerio)
Actinopterygii zgc:63645 33
  • 68.95 (n)
MTMR4 34
  • 63 (a)
zgc63645 33
fruit fly
(Drosophila melanogaster)
Insecta CG3632 34 35
  • 33 (a)
(Caenorhabditis elegans)
Secernentea T24A11.1a 35
  • 32 (a)
T24A11.1b 35
  • 31 (a)
Species where no ortholog for MTMR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTMR4 Gene

Gene Tree for MTMR4 (if available)
Gene Tree for MTMR4 (if available)
Evolutionary constrained regions (ECRs) for MTMR4: view image

Paralogs for MTMR4 Gene

Paralogs for MTMR4 Gene

(9) SIMAP similar genes for MTMR4 Gene using alignment to 7 proteins:

  • J3KT95_HUMAN
  • J3QR65_HUMAN
  • J3QS98_HUMAN
genes like me logo Genes that share paralogs with MTMR4: view

Variants for MTMR4 Gene

Sequence variations from dbSNP and Humsavar for MTMR4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000021174 -- 58,496,471(-) C/A intron_variant
rs1000049219 -- 58,513,003(-) T/G intron_variant
rs1000445365 -- 58,497,659(-) C/A/T intron_variant
rs1000472762 -- 58,519,519(-) C/G/T upstream_transcript_variant
rs1000517834 -- 58,507,715(-) ACAACAA/ACAA intron_variant

Variation tolerance for MTMR4 Gene

Residual Variation Intolerance Score: 16.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.98; 99.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTMR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MTMR4 Gene

Disorders for MTMR4 Gene

Additional Disease Information for MTMR4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MTMR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTMR4 Gene

Publications for MTMR4 Gene

  1. Phosphoinositide cycle gene polymorphisms affect the plasma lipid profile in the Quebec Family Study. (PMID: 19329342) Dolley G … Vohl MC (Molecular genetics and metabolism 2009) 3 22 44 58
  2. Genome-wide association scan for childhood caries implicates novel genes. (PMID: 21940522) Shaffer JR … Marazita ML (Journal of dental research 2011) 3 44 58
  3. MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes. (PMID: 20061380) Yu J … Tang H (The Journal of biological chemistry 2010) 3 22 58
  4. The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. (PMID: 19125695) Plant PJ … Batt J (The Biochemical journal 2009) 3 22 58
  5. FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate. (PMID: 11302699) Zhao R … Zhao ZJ (Experimental cell research 2001) 3 4 58

Products for MTMR4 Gene

Sources for MTMR4 Gene

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