Aliases for MTMR4 Gene

Aliases for MTMR4 Gene

  • Myotubularin Related Protein 4 2 3 5
  • FYVE Domain-Containing Dual Specificity Protein Phosphatase 2 3 4
  • Zinc Finger FYVE Domain-Containing Protein 11 3 4
  • Myotubularin-Related Protein 4 3 4
  • EC 4 54
  • FYVE-DSP2 3 4
  • ZFYVE11 3 4
  • Zinc Finger, FYVE Domain Containing 11 3
  • KIAA0647 4

External Ids for MTMR4 Gene

Previous GeneCards Identifiers for MTMR4 Gene

  • GC17M056311
  • GC17M059048
  • GC17M056908
  • GC17M057041
  • GC17M053921
  • GC17M056566
  • GC17M051927

Summaries for MTMR4 Gene

GeneCards Summary for MTMR4 Gene

MTMR4 (Myotubularin Related Protein 4) is a Protein Coding gene. Among its related pathways are PI Metabolism and TGF-beta receptor signaling activates SMADs. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein serine/threonine phosphatase activity. An important paralog of this gene is MTMR3.

UniProtKB/Swiss-Prot Summary for MTMR4 Gene

  • Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).

Additional gene information for MTMR4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MTMR4 Gene

Genomics for MTMR4 Gene

GeneHancer (GH) Regulatory Elements for MTMR4 Gene

Promoters and enhancers for MTMR4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J058511 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +1.9 1894 8.9 E2F8 SIN3A SP1 ZBTB40 CTCF SIX5 ZBTB6 FOXA1 RBPJ POLR2A MTMR4 MKS1 SRSF1 TRIM37 RAD51C SMG8 VEZF1 ENSG00000108387 GDPD1 ENSG00000224738
GH17J058630 Promoter/Enhancer 2.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 -113.8 -113771 2.6 FOXK2 SIN3A ZBTB40 SP1 CTCF SIX5 LCORL FOXA1 MLX RBPJ ENSG00000212195 LOC105371842 SRSF1 MKS1 DHX40 VEZF1 TRIM37 RAD51C SMG8 ENSG00000224738
GH17J058400 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 9.1 +115.4 115384 3.9 ZNF133 NFIB SP1 PRDM1 CREB1 ZBTB33 PKNOX1 CEBPB ZNF629 HDAC1 TRIM37 RAD51C MKS1 SRSF1 SUPT4H1 HSF5 TSPOAP1 ENSG00000264112 LPO MTMR4
GH17J058374 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.2 +137.9 137919 10.8 FOXA1 LCORL MLX RBPJ NR2F1 ATF1 NR2F6 CREB1 MIXL1 CC2D1A TRIM37 RAD51C RNF43 SRSF1 SUPT4H1 MKS1 HSF5 LPO EPX MSX2P1
GH17J058575 Enhancer 1 Ensembl ENCODE 11.5 -58.5 -58491 3.2 PPP1R10 CTCF ZNF217 COPS2 HLF RAD21 ELF3 MAFK TFE3 BACH1 TRIM37 RAD51C ENSG00000224738 MKS1 ENSG00000108387 SEPTIN4 SRSF1 MTMR4 VEZF1 TEX14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MTMR4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MTMR4 gene promoter:
  • C/EBPalpha
  • CREB
  • deltaCREB
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Lmo2

Genomic Locations for MTMR4 Gene

Genomic Locations for MTMR4 Gene
28,582 bases
Minus strand
28,374 bases
Minus strand

Genomic View for MTMR4 Gene

Genes around MTMR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTMR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTMR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTMR4 Gene

Proteins for MTMR4 Gene

  • Protein details for MTMR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myotubularin-related protein 4
    Protein Accession:
    Secondary Accessions:
    • D3DTZ6
    • Q8IV27
    • Q9Y4D5

    Protein attributes for MTMR4 Gene

    1195 amino acids
    Molecular mass:
    133353 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTMR4 Gene

Selected DME Specific Peptides for MTMR4 Gene


Post-translational modifications for MTMR4 Gene

  • Ubiquitination at Lys202 and Lys257
  • Modification sites at PhosphoSitePlus

Domains & Families for MTMR4 Gene

Gene Families for MTMR4 Gene

Suggested Antigen Peptide Sequences for MTMR4 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger FYVE domain-containing protein 11 (MTMR4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
genes like me logo Genes that share domains with MTMR4: view

Function for MTMR4 Gene

Molecular function for MTMR4 Gene

UniProtKB/Swiss-Prot Function:
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=; Evidence=. ;.
GENATLAS Biochemistry:
myotubularin related protein 4 ,expressed in brain,related to KIAA0371 putative hyposine phosphatase family

Enzyme Numbers (IUBMB) for MTMR4 Gene

Phenotypes From GWAS Catalog for MTMR4 Gene

Gene Ontology (GO) - Molecular Function for MTMR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity TAS,IEA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 20061380
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with MTMR4: view
genes like me logo Genes that share phenotypes with MTMR4: view

Animal Models for MTMR4 Gene

MGI Knock Outs for MTMR4:
  • Mtmr4 Mtmr4<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTMR4 Gene

Localization for MTMR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTMR4 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTMR4 gene
Compartment Confidence
endosome 5
cytosol 5
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MTMR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IDA 16787938
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MTMR4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTMR4 Gene

Pathways & Interactions for MTMR4 Gene

genes like me logo Genes that share pathways with MTMR4: view

SIGNOR curated interactions for MTMR4 Gene


Gene Ontology (GO) - Biological Process for MTMR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS,IEA 9736772
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway IEA --
GO:0014894 response to denervation involved in regulation of muscle adaptation IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with MTMR4: view

Drugs & Compounds for MTMR4 Gene

(2) Drugs for MTMR4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for MTMR4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with MTMR4: view

Transcripts for MTMR4 Gene

mRNA/cDNA for MTMR4 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTMR4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a ·
SP1: - - -
SP2: -
SP3: - - - - - - - - - - - - - - - - - - - -
SP5: -

ExUns: 19b · 19c · 19d

Relevant External Links for MTMR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTMR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTMR4 Gene

Protein differential expression in normal tissues from HIPED for MTMR4 Gene

This gene is overexpressed in Pancreas (42.7), Monocytes (11.2), and Platelet (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MTMR4 Gene

Protein tissue co-expression partners for MTMR4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTMR4 Gene:


SOURCE GeneReport for Unigene cluster for MTMR4 Gene:


mRNA Expression by UniProt/SwissProt for MTMR4 Gene:

Tissue specificity: Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.

Evidence on tissue expression from TISSUES for MTMR4 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with MTMR4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTMR4 Gene

Orthologs for MTMR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTMR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTMR4 33 32
  • 99.58 (n)
(Canis familiaris)
Mammalia MTMR4 33 32
  • 92.13 (n)
(Rattus norvegicus)
Mammalia Mtmr4 32
  • 89.37 (n)
(Mus musculus)
Mammalia Mtmr4 17 33 32
  • 89.32 (n)
(Bos Taurus)
Mammalia MTMR4 33 32
  • 87.56 (n)
(Monodelphis domestica)
Mammalia MTMR4 33
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia MTMR4 33
  • 73 (a)
(Gallus gallus)
Aves MTMR4 33 32
  • 73.22 (n)
(Anolis carolinensis)
Reptilia MTMR4 33
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtmr4 32
  • 70.01 (n)
(Danio rerio)
Actinopterygii zgc:63645 32
  • 68.95 (n)
MTMR4 33
  • 63 (a)
zgc63645 32
fruit fly
(Drosophila melanogaster)
Insecta CG3632 33 34
  • 33 (a)
(Caenorhabditis elegans)
Secernentea T24A11.1a 34
  • 32 (a)
T24A11.1b 34
  • 31 (a)
Species where no ortholog for MTMR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTMR4 Gene

Gene Tree for MTMR4 (if available)
Gene Tree for MTMR4 (if available)
Evolutionary constrained regions (ECRs) for MTMR4: view image

Paralogs for MTMR4 Gene

(9) SIMAP similar genes for MTMR4 Gene using alignment to 7 proteins:

  • J3KT95_HUMAN
  • J3QR65_HUMAN
  • J3QS98_HUMAN
genes like me logo Genes that share paralogs with MTMR4: view

Variants for MTMR4 Gene

Sequence variations from dbSNP and Humsavar for MTMR4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000021174 -- 58,496,471(-) C/A intron_variant
rs1000049219 -- 58,513,003(-) T/G intron_variant
rs1000445365 -- 58,497,659(-) C/A/T intron_variant
rs1000472762 -- 58,519,519(-) C/G/T upstream_transcript_variant
rs1000517834 -- 58,507,715(-) ACAACAA/ACAA intron_variant

Variation tolerance for MTMR4 Gene

Residual Variation Intolerance Score: 16.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.98; 99.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTMR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MTMR4 Gene

Disorders for MTMR4 Gene

Additional Disease Information for MTMR4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MTMR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTMR4 Gene

Publications for MTMR4 Gene

  1. Phosphoinositide cycle gene polymorphisms affect the plasma lipid profile in the Quebec Family Study. (PMID: 19329342) Dolley G … Vohl MC (Molecular genetics and metabolism 2009) 3 23 43 56
  2. Genome-wide association scan for childhood caries implicates novel genes. (PMID: 21940522) Shaffer JR … Marazita ML (Journal of dental research 2011) 3 43 56
  3. MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes. (PMID: 20061380) Yu J … Tang H (The Journal of biological chemistry 2010) 3 23 56
  4. The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. (PMID: 19125695) Plant PJ … Batt J (The Biochemical journal 2009) 3 23 56
  5. FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate. (PMID: 11302699) Zhao R … Zhao ZJ (Experimental cell research 2001) 3 4 56

Products for MTMR4 Gene

Sources for MTMR4 Gene