Aliases for MTMR3 Gene
- Myotubularin Related Protein 3 2 3 5
- FYVE Domain-Containing Dual Specificity Protein Phosphatase 1 3 4
- Phosphatidylinositol-3,5-Bisphosphate 3-Phosphatase 3 4
- Zinc Finger FYVE Domain-Containing Protein 10 3 4
- Phosphatidylinositol-3-Phosphate Phosphatase 3 4
- Myotubularin-Related Protein 3 3 4
- EC 220.127.116.11 4 52
External Ids for MTMR3 Gene
Previous GeneCards Identifiers for MTMR3 Gene
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MTMR3 Gene
MTMR3 (Myotubularin Related Protein 3) is a Protein Coding gene. Diseases associated with MTMR3 include Nephrotic Syndrome, Type 7 and Charcot-Marie-Tooth Disease, Type 4B3. Among its related pathways are superpathway of inositol phosphate compounds and Autophagy - animal. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein serine/threonine phosphatase activity. An important paralog of this gene is MTMR4.
UniProtKB/Swiss-Prot Summary for MTMR3 Gene
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).