Aliases for MTMR3 Gene
Aliases for MTMR3 Gene
- Myotubularin Related Protein 3 2 3 5
- FYVE Domain-Containing Dual Specificity Protein Phosphatase 1 3 4
- Phosphatidylinositol-3,5-Bisphosphate 3-Phosphatase 3 4
- Zinc Finger FYVE Domain-Containing Protein 10 3 4
- Phosphatidylinositol-3-Phosphate Phosphatase 3 4
- EC 3.1.3.48 4 56
- FYVE-DSP1 3 4
- ZFYVE10 3 4
External Ids for MTMR3 Gene
- HGNC: 7451
- Entrez Gene: 8897
- Ensembl: ENSG00000100330
- OMIM: 603558
- UniProtKB: Q13615
Previous GeneCards Identifiers for MTMR3 Gene
- GC22P026975
- GC22P028603
- GC22P030279
- GC22P013241
Summaries for MTMR3 Gene
-
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MTMR3 Gene
MTMR3 (Myotubularin Related Protein 3) is a Protein Coding gene. Diseases associated with MTMR3 include Adult Syndrome. Among its related pathways are Inositol phosphate metabolism (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein serine/threonine phosphatase activity. An important paralog of this gene is MTMR4.
UniProtKB/Swiss-Prot for MTMR3 Gene
-
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).
Additional gene information for MTMR3 Gene
- Monarch Initiative
- Search for MTMR3 at DataMed
- Search for MTMR3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTMR3 Gene
Genomics for MTMR3 Gene
GeneHancer (GH) Regulatory Elements for MTMR3 Gene
Promoters and enhancers for MTMR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MTMR3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MTMR3 Gene
Genomic Locations for MTMR3 Gene
- chr22:29,883,155-30,030,868
- (GRCh38/hg38)
- Size:
- 147,714 bases
- Orientation:
- Plus strand
- chr22:30,279,144-30,426,857
- (GRCh37/hg19)
Genomic View for MTMR3 Gene
Genes around MTMR3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.2 by Ensembl
- 22q12.2 by Entrez Gene
- 22q12.2 by HGNC
MTMR3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MTMR3 Gene
Proteins for MTMR3 Gene
-
Protein details for MTMR3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13615-MTMR3_HUMAN
- Recommended name:
- Myotubularin-related protein 3
- Protein Accession:
- Q13615
- A5PL26
- A7MD32
- Q9NYN5
- Q9NYN6
- Q9UDX6
- Q9UEG3
Protein attributes for MTMR3 Gene
- Size:
- 1198 amino acids
- Molecular mass:
- 133619 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA20826.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MTMR3 Gene
Selected DME Specific Peptides for MTMR3 Gene
- Q13615:
-
- GHKFADRCGH
- HCSDGWDRT
- YRTIEGF
- FMGMANIH
- PDPGNWLSALESTKWL
- PQKLLILDARSY
- GAVIARC
Post-translational modifications for MTMR3 Gene
Other Protein References for MTMR3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MTMR3
-
Abcam antibodies for MTMR3
- Invitrogen Antibodies for MTMR3
- Search GeneTex for Antibodies for MTMR3
-
Santa Cruz Biotechnology (SCBT) Antibodies for MTMR3
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MTMR3
- Origene Custom Protein Services for MTMR3
- Search GeneTex for Proteins for MTMR3
-
Abcam proteins for MTMR3
Assay Products
Domains & Families for MTMR3 Gene
Gene Families for MTMR3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MTMR3 Gene
Suggested Antigen Peptide Sequences for MTMR3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13615UniProtKB/Swiss-Prot:
MTMR3_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Function for MTMR3 Gene
Molecular function for MTMR3 Gene
- GENATLAS Biochemistry:
- myotubularin related protein 3,expressed in skeletal muscle,heart,placenta,brain,liver and pancreas
- UniProtKB/Swiss-Prot CatalyticActivity:
- 1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol + phosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- UniProtKB/Swiss-Prot Function:
- Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).
Enzyme Numbers (IUBMB) for MTMR3 Gene
Phenotypes From GWAS Catalog for MTMR3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004438 | phosphatidylinositol-3-phosphatase activity | TAS | -- |
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004722 | protein serine/threonine phosphatase activity | IDA,TAS | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IDA | 10733931 |
| GO:0005515 | protein binding | IPI | 26787466 |
Phenotypes for MTMR3 Gene
- MGI mutant phenotypes for MTMR3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MTMR3:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased shRNA abundance
- Decreased Salmonella proliferation
- Increased Erk phosphorylation after EGF stimulation
- Increased Akt phosphorylation after EGF stimulation
Animal Model Products
-
Taconic Biosciences Mouse Models for MTMR3
- Cyagen custom Knockout/knockin (KOKI) mouse models for MTMR3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MTMR3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTMR3 gene
- Search ViGene Biosciences for MTMR3
CRISPR Products
-
OriGene CRISPR knockouts for MTMR3
- genomics-online: gRNA clones - Search results for 108 available MTMR3 gene related products
- Overview of 108 available MTMR3 gene related products
- Applied Biological Materials CRISPR for MTMR3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTMR3
- GenScript: Design CRISPR guide RNA sequences for MTMR3
miRNA for MTMR3 Gene
- miRTarBase miRNAs that target MTMR3
-
- hsa-mir-181a-5p (MIRT006871)
- hsa-mir-877-5p (MIRT037294)
- hsa-mir-423-5p (MIRT038158)
- hsa-mir-106b-3p (MIRT038555)
- hsa-mir-125b-5p (MIRT045920)
- hsa-mir-27b-3p (MIRT046210)
- hsa-mir-106a-5p (MIRT048345)
- hsa-mir-17-5p (MIRT050972)
- hsa-mir-99a-5p (MIRT053347)
- hsa-mir-20a-5p (MIRT157585)
- hsa-mir-93-5p (MIRT157586)
- hsa-mir-106b-5p (MIRT157590)
- hsa-mir-20b-5p (MIRT157601)
- hsa-mir-519d-3p (MIRT157612)
- hsa-mir-15a-5p (MIRT300992)
- hsa-mir-16-5p (MIRT300993)
- hsa-mir-103a-3p (MIRT300994)
- hsa-mir-107 (MIRT300995)
- hsa-mir-15b-5p (MIRT300996)
- hsa-mir-195-5p (MIRT300997)
- hsa-mir-424-5p (MIRT300998)
- hsa-mir-497-5p (MIRT300999)
- hsa-mir-4310 (MIRT301000)
- hsa-mir-4524a-5p (MIRT301001)
- hsa-mir-4524b-5p (MIRT301002)
- hsa-mir-6838-5p (MIRT301003)
- hsa-mir-7157-5p (MIRT301004)
- hsa-mir-218-5p (MIRT440205)
- hsa-mir-646 (MIRT566701)
- hsa-mir-490-3p (MIRT566702)
- hsa-mir-548x-3p (MIRT566703)
- hsa-mir-548j-3p (MIRT566704)
- hsa-mir-548aq-3p (MIRT566705)
- hsa-mir-548am-3p (MIRT566706)
- hsa-mir-548aj-3p (MIRT566707)
- hsa-mir-548ah-3p (MIRT566708)
- hsa-mir-548ae-3p (MIRT566709)
- hsa-mir-548z (MIRT566710)
- hsa-mir-548h-3p (MIRT566711)
- hsa-mir-548d-3p (MIRT566712)
- hsa-mir-548bb-3p (MIRT566713)
- hsa-mir-548ac (MIRT566714)
- hsa-mir-503-5p (MIRT566715)
- hsa-mir-6848-3p (MIRT572909)
- hsa-mir-6843-3p (MIRT572910)
- hsa-mir-196a-3p (MIRT572911)
- hsa-mir-8073 (MIRT572912)
- hsa-mir-3128 (MIRT572913)
- hsa-mir-221-5p (MIRT572914)
- hsa-mir-6884-3p (MIRT572915)
- hsa-mir-1914-3p (MIRT738512)
- hsa-mir-3188 (MIRT740937)
- hsa-mir-4257 (MIRT743417)
- hsa-mir-4636 (MIRT746312)
- hsa-mir-5194 (MIRT749976)
- hsa-mir-595 (MIRT751602)
- hsa-mir-6736-3p (MIRT754201)
- hsa-mir-6738-5p (MIRT754271)
- hsa-mir-6847-5p (MIRT757478)
- hsa-mir-6866-5p (MIRT757937)
- hsa-mir-6873-5p (MIRT758075)
miRNA Products
- Search ViGene Biosciences for MTMR3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MTMR3
- Browse OriGene Inhibitory RNA Products For MTMR3
- genomics-online: shRNA clones - Search results for 108 available MTMR3 gene related products
- Overview of 108 available MTMR3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MTMR3 gene
Clone Products
-
OriGene ORF clones in human for MTMR3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for MTMR3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTMR3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MTMR3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MTMR3
-
ViGene Biosciences adenoviral particle packaged cDNA for MTMR3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MTMR3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTMR3 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTMR3 Gene
Localization for MTMR3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MTMR3 Gene
- Cytoplasm. Membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| cytoskeleton | 2 |
| endosome | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA,IEA | 10733931 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA,IDA | 10733931 |
| GO:0019898 | extrinsic component of membrane | IDA | 11676921 |
Pathways & Interactions for MTMR3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Inositol phosphate metabolism (KEGG) | ||
| 2 | Metabolism |
.37
|
|
| 3 | PI Metabolism |
.63
|
|
| 4 | Autophagy - animal | ||
| 5 | Cellular Senescence (REACTOME) | ||
Pathways by source for MTMR3 Gene
3 BioSystems pathways for MTMR3 Gene
7 Reactome pathways for MTMR3 Gene
4 KEGG pathways for MTMR3 Gene
Interacting Proteins for MTMR3 Gene
Selected Interacting proteins:
Q13615-MTMR3_HUMAN
ENSP00000384651
for MTMR3 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IDA | 10733931 |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | -- |
| GO:0016236 | macroautophagy | TAS | -- |
| GO:0016311 | dephosphorylation | IEA | -- |
No data available for SIGNOR curated interactions for MTMR3 Gene
Drugs & Compounds for MTMR3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14265-44-2 |
|
Transcripts for MTMR3 Gene
mRNA/cDNA for MTMR3 Gene
- (16) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (353) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MTMR3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MTMR3
- genomics-online: gRNA clones - Search results for 108 available MTMR3 gene related products
- Overview of 108 available MTMR3 gene related products
- Applied Biological Materials CRISPR for MTMR3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTMR3
- GenScript: Design CRISPR guide RNA sequences for MTMR3
miRNA Products
- Search ViGene Biosciences for MTMR3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MTMR3
- Browse OriGene Inhibitory RNA Products For MTMR3
- genomics-online: shRNA clones - Search results for 108 available MTMR3 gene related products
- Overview of 108 available MTMR3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MTMR3 gene
Clone Products
-
OriGene ORF clones in human for MTMR3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for MTMR3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTMR3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MTMR3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 17a | · | 17b | · | 17c |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: |
Expression for MTMR3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for MTMR3 Gene
This gene is overexpressed in Whole Blood (x7.2).
This gene is overexpressed in Blymphocyte (18.8), Heart (12.4), and Testis (9.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTMR3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MTMR3 Gene:
MTMR3SOURCE GeneReport for Unigene cluster for MTMR3 Gene:
Hs.474536Evidence on tissue expression from TISSUES for MTMR3 Gene
- Nervous system(4.8)
- Liver(4.2)
- Lung(2.7)
Primer Products
-
OriGene qPCR primer pairs for MTMR3
- genomics-online: primer clones - Search results for 108 available MTMR3 gene related products
- Overview of 108 available MTMR3 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTMR3 Gene
Orthologs for MTMR3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MTMR3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MTMR3 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MTMR3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mtmr3 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mtmr3 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MTMR3 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MTMR3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MTMR3 33 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mtmr3 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Mtmr3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | MTMR3 (3 of 3) 34 |
|
OneToMany | |
| mtmr3 33 34 |
|
||||
| MTMR3 (2 of 3) 34 |
|
OneToMany | |||
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG3632 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | T24A11.1a 35 |
|
|
|
| T24A11.1b 35 |
|
|
- Species where no ortholog for MTMR3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MTMR3 Gene
Paralogs for MTMR3 Gene
(10) SIMAP similar genes for MTMR3 Gene using alignment to 4 proteins:
Variants for MTMR3 Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035656 | A breast cancer sample | p.Val221Leu | |||
| rs1000014903 | -- | 30,025,903(+) | T/C | 3_prime_UTR_variant | |
| rs1000017635 | -- | 29,890,985(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000019111 | -- | 30,005,441(+) | C/G | intron_variant | |
| rs1000024493 | -- | 29,965,453(+) | G/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv760n67 | CNV | gain | 20364138 |
| esv2667111 | CNV | deletion | 23128226 |
| esv26961 | CNV | loss | 19812545 |
| esv2724133 | CNV | deletion | 23290073 |
| esv27258 | CNV | gain | 19812545 |
| esv2763694 | CNV | loss | 21179565 |
| esv3307560 | CNV | mobile element insertion | 20981092 |
| esv3331654 | CNV | insertion | 20981092 |
| esv3441917 | CNV | insertion | 20981092 |
| esv3568352 | CNV | loss | 25503493 |
| esv3568353 | CNV | loss | 25503493 |
| esv3568355 | CNV | loss | 25503493 |
| esv3647549 | CNV | loss | 21293372 |
| esv3647550 | CNV | loss | 21293372 |
| esv3647551 | CNV | loss | 21293372 |
| nsv1058511 | CNV | loss | 25217958 |
| nsv1064489 | CNV | loss | 25217958 |
| nsv1109464 | CNV | deletion | 24896259 |
| nsv1110864 | OTHER | inversion | 24896259 |
| nsv3591 | CNV | deletion | 18451855 |
| nsv523696 | CNV | gain | 19592680 |
| nsv588883 | CNV | loss | 21841781 |
| nsv829163 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
4.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.84;
58.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MTMR3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTMR3 Gene
Disorders for MTMR3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| adult syndrome |
|
|
Search MTMR3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MTMR3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MTMR3 Gene
Publications for MTMR3 Gene
- FYVE-DSP1, a dual-specificity protein phosphatase containing an FYVE domain. (PMID: 10733931) Zhao R … Zhao ZJ (Biochemical and biophysical research communications 2000) 3 4 22 58
- Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. (PMID: 9736772) Laporte J … Mandel JL (Human molecular genetics 1998) 2 3 4 58
- A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast. (PMID: 8640223) Laporte J … Dahl N (Nature genetics 1996) 2 3 4 58
- A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. (PMID: 22197929) Yu XQ … Liu JJ (Nature genetics 2011) 3 44 58
- A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. (PMID: 21725308) Hu Z … Shen H (Nature genetics 2011) 3 44 58
Products for MTMR3 Gene
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- Mammalian expression: PiggyBac
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Sources for MTMR3 Gene
- (1) GeneCards
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- (3) EntrezGene
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- (28) ASD
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- (47) Atlas
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- (55) miRBase
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- (66) GenScript
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- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
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- (84) Vector BioLabs
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