Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MTMR11 Gene

Aliases for MTMR11 Gene

  • Myotubularin Related Protein 11 2 3 5
  • Cisplatin Resistance-Associated Protein 3 4
  • Cisplatin Resistance Associated 2 3
  • HCRA 3 4
  • Myotubularin-Related Protein 11 3
  • CRA 3

External Ids for MTMR11 Gene

Previous GeneCards Identifiers for MTMR11 Gene

  • GC01M146714
  • GC01M148167
  • GC01M149900
  • GC01M121281

Summaries for MTMR11 Gene

GeneCards Summary for MTMR11 Gene

MTMR11 (Myotubularin Related Protein 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity. An important paralog of this gene is MTMR10.

UniProtKB/Swiss-Prot for MTMR11 Gene

  • Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).

Additional gene information for MTMR11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTMR11 Gene

Genomics for MTMR11 Gene

GeneHancer (GH) Regulatory Elements for MTMR11 Gene

Promoters and enhancers for MTMR11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J150008 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.5 -73.3 -73310 2.9 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 OTUD7B PRPF3 SETDB1 ARNT MTMR11 ADAMTSL4 SV2A UBE2D3P3 RPRD2 CTSK
GH01J150006 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 18.9 -70.4 -70422 1.7 JUN FOSL1 ZFHX2 EGR1 TRIM24 FOS EGR2 SMARCE1 L3MBTL2 DPF2 MTMR11 SF3B4 OTUD7B SV2A CA14 PIR49087
GH01J149898 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.2 +37.1 37054 1.8 PKNOX1 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 PIR37951 BOLA1 PRPF3 SF3B4 ARNT UBE2D3P3 GOLPH3L RPRD2 SV2A CTSK
GH01J150156 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -225.0 -225034 10.3 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B YBX1 IRF4 POLR2B ZNF766 LOC105371433 PLEKHO1 SV2A MTMR11 CA14 MCL1 PRPF3 MRPS21 ANP32E RPRD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MTMR11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MTMR11 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • IRF-1
  • SREBP-1b
  • SREBP-1a
  • SREBP-1c
  • aMEF-2
  • MEF-2A

Genomic Locations for MTMR11 Gene

Genomic Locations for MTMR11 Gene
8,249 bases
Minus strand
8,249 bases
Minus strand

Genomic View for MTMR11 Gene

Genes around MTMR11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTMR11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTMR11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTMR11 Gene

Proteins for MTMR11 Gene

  • Protein details for MTMR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myotubularin-related protein 11
    Protein Accession:
    Secondary Accessions:
    • B3KUE4
    • B4DJI6
    • B4DQF5
    • B4E3Q6
    • Q3ZCP7
    • Q5SZ62
    • Q6P2Q8
    • Q99752
    • Q99753

    Protein attributes for MTMR11 Gene

    709 amino acids
    Molecular mass:
    79545 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB36952.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305}; Sequence=AAB36953.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305}; Sequence=AAH94756.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MTMR11 Gene

neXtProt entry for MTMR11 Gene

Post-translational modifications for MTMR11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTMR11 Gene

No data available for DME Specific Peptides for MTMR11 Gene

Domains & Families for MTMR11 Gene

Gene Families for MTMR11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MTMR11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
genes like me logo Genes that share domains with MTMR11: view

Function for MTMR11 Gene

Molecular function for MTMR11 Gene

UniProtKB/Swiss-Prot Function:
Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).

Phenotypes From GWAS Catalog for MTMR11 Gene

genes like me logo Genes that share phenotypes with MTMR11: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MTMR11 Gene

Localization for MTMR11 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTMR11 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MTMR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16787938
GO:0070062 extracellular exosome HDA 18570454
genes like me logo Genes that share ontologies with MTMR11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MTMR11 Gene

Pathways & Interactions for MTMR11 Gene

SuperPathways for MTMR11 Gene

No Data Available

Interacting Proteins for MTMR11 Gene

Gene Ontology (GO) - Biological Process for MTMR11 Gene


No data available for Pathways by source and SIGNOR curated interactions for MTMR11 Gene

Drugs & Compounds for MTMR11 Gene

No Compound Related Data Available

Transcripts for MTMR11 Gene

Unigene Clusters for MTMR11 Gene

Myotubularin related protein 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTMR11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - -
SP11: - - - - - - -
SP12: -
SP14: -

ExUns: 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP7: - - - -
SP8: - - -
SP9: - - -
SP10: - -
SP15: -

Relevant External Links for MTMR11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTMR11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTMR11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTMR11 Gene

This gene is overexpressed in Colon - Transverse (x8.2).

Protein differential expression in normal tissues from HIPED for MTMR11 Gene

This gene is overexpressed in Testis (25.0), Breast (18.1), and Spinal cord (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MTMR11 Gene

Protein tissue co-expression partners for MTMR11 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTMR11 Gene:


SOURCE GeneReport for Unigene cluster for MTMR11 Gene:


mRNA Expression by UniProt/SwissProt for MTMR11 Gene:

Tissue specificity: Expressed in bone marrow, spleen and thymus.

Evidence on tissue expression from TISSUES for MTMR11 Gene

  • Nervous system(4.4)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with MTMR11: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MTMR11 Gene

Orthologs for MTMR11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTMR11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTMR11 34 33
  • 99.67 (n)
(Bos Taurus)
Mammalia MTMR11 34 33
  • 91.49 (n)
(Canis familiaris)
Mammalia MTMR11 34 33
  • 90.94 (n)
(Rattus norvegicus)
Mammalia Mtmr11 33
  • 86.18 (n)
(Mus musculus)
Mammalia Mtmr11 16 34 33
  • 85.74 (n)
(Monodelphis domestica)
Mammalia MTMR11 34
  • 76 (a)
(Gallus gallus)
Aves MTMR11 34
  • 46 (a)
(Anolis carolinensis)
Reptilia MTMR11 34
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtmr11 33
  • 52.01 (n)
(Danio rerio)
Actinopterygii LOC101882209 33
  • 52.92 (n)
mtmr11 34
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14411 34
  • 23 (a)
Species where no ortholog for MTMR11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTMR11 Gene

Gene Tree for MTMR11 (if available)
Gene Tree for MTMR11 (if available)
Evolutionary constrained regions (ECRs) for MTMR11: view image

Paralogs for MTMR11 Gene

Paralogs for MTMR11 Gene

genes like me logo Genes that share paralogs with MTMR11: view

Variants for MTMR11 Gene

Sequence variations from dbSNP and Humsavar for MTMR11 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000623324 -- 149,929,590(-) T/G 3_prime_UTR_variant, intron_variant
rs1000743503 -- 149,929,236(-) T/C 3_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1001907372 -- 149,928,480(-) C/A/G downstream_transcript_variant
rs1002256578 -- 149,928,737(-) G/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1002669144 -- 149,933,394(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MTMR11 Gene

Variant ID Type Subtype PubMed ID
nsv831537 CNV loss 17160897

Variation tolerance for MTMR11 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.22; 88.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTMR11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTMR11 Gene

Disorders for MTMR11 Gene

Additional Disease Information for MTMR11

No disorders were found for MTMR11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTMR11 Gene

Publications for MTMR11 Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 44 58
  2. A common 93-kb duplicated DNA sequence at 1q21.2 in acute lymphoblastic leukemia and Burkitt lymphoma. (PMID: 17498563) La Starza R … Mecucci C (Cancer genetics and cytogenetics 2007) 4 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. (PMID: 12495846) Wishart MJ … Dixon JE (Trends in cell biology 2002) 2 3 58
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58

Products for MTMR11 Gene

Sources for MTMR11 Gene

Loading form....