Aliases for MTIF3 Gene
External Ids for MTIF3 Gene
Previous GeneCards Identifiers for MTIF3 Gene
This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Oct 2009]
GeneCards Summary for MTIF3 Gene
MTIF3 (Mitochondrial Translational Initiation Factor 3) is a Protein Coding gene. Diseases associated with MTIF3 include Hallucinogen Abuse. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity and ribosomal small subunit binding.
UniProtKB/Swiss-Prot Summary for MTIF3 Gene
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.