During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to... See more...

Aliases for MTIF2 Gene

Aliases for MTIF2 Gene

  • Mitochondrial Translational Initiation Factor 2 2 3 5
  • Translation Initiation Factor IF-2, Mitochondrial 3 4
  • IF-2(Mt) 4
  • IF2(Mt) 4
  • IF-2mt 3
  • IF-2Mt 4

External Ids for MTIF2 Gene

Previous GeneCards Identifiers for MTIF2 Gene

  • GC02M055501
  • GC02M055649
  • GC02M055438
  • GC02M055375
  • GC02M055317
  • GC02M055463
  • GC02M055198

Summaries for MTIF2 Gene

Entrez Gene Summary for MTIF2 Gene

  • During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]

GeneCards Summary for MTIF2 Gene

MTIF2 (Mitochondrial Translational Initiation Factor 2) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is EIF2S3.

UniProtKB/Swiss-Prot Summary for MTIF2 Gene

  • One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

Gene Wiki entry for MTIF2 Gene

Additional gene information for MTIF2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MTIF2 Gene

Genomics for MTIF2 Gene

GeneHancer (GH) Regulatory Elements for MTIF2 Gene


GeneHancers around MTIF2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MTIF2

Top Transcription factor binding sites by QIAGEN in the MTIF2 gene promoter:
  • aMEF-2
  • MEF-2A
  • TBP
  • TFIID
  • ZID

Genomic Locations for MTIF2 Gene

Genomic Locations for MTIF2 Gene
chr2:55,236,595-55,269,347
(GRCh38/hg38)
Size:
32,753 bases
Orientation:
Minus strand
chr2:55,463,731-55,496,483
(GRCh37/hg19)
Size:
32,753 bases
Orientation:
Minus strand

Genomic View for MTIF2 Gene

Genes around MTIF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTIF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTIF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTIF2 Gene

Proteins for MTIF2 Gene

  • Protein details for MTIF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46199-IF2M_HUMAN
    Recommended name:
    Translation initiation factor IF-2, mitochondrial
    Protein Accession:
    P46199
    Secondary Accessions:
    • D6W5D0

    Protein attributes for MTIF2 Gene

    Size:
    727 amino acids
    Molecular mass:
    81317 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for MTIF2 Gene

neXtProt entry for MTIF2 Gene

Post-translational modifications for MTIF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTIF2 Gene

Domains & Families for MTIF2 Gene

Gene Families for MTIF2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MTIF2 Gene

GenScript: Design optimal peptide antigens:
  • Translation initiation factor IF-2, mitochondrial (IF2M_HUMAN)
  • MTIF2 protein (Q05DA1_HUMAN)
  • MTIF2 protein (Q6P1N2_HUMAN)
  • MTIF2 protein (Q7Z5U0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P46199

UniProtKB/Swiss-Prot:

IF2M_HUMAN :
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
genes like me logo Genes that share domains with MTIF2: view

Function for MTIF2 Gene

Molecular function for MTIF2 Gene

UniProtKB/Swiss-Prot Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
GENATLAS Biochemistry:
mitochondrial translational initiation factor 2,catalyzing the binding of initiation tRNA to mitochondrial 28S ribosomes

Phenotypes From GWAS Catalog for MTIF2 Gene

Gene Ontology (GO) - Molecular Function for MTIF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003743 translation initiation factor activity IEA --
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
GO:0008135 translation factor activity, RNA binding ISS --
genes like me logo Genes that share ontologies with MTIF2: view
genes like me logo Genes that share phenotypes with MTIF2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTIF2 Gene

Localization for MTIF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTIF2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTIF2 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MTIF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion TAS 12095986
genes like me logo Genes that share ontologies with MTIF2: view

Pathways & Interactions for MTIF2 Gene

genes like me logo Genes that share pathways with MTIF2: view

Pathways by source for MTIF2 Gene

Gene Ontology (GO) - Biological Process for MTIF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006446 regulation of translational initiation TAS 7829522
GO:0032790 ribosome disassembly ISS --
GO:0070124 mitochondrial translational initiation IBA,ISS --
genes like me logo Genes that share ontologies with MTIF2: view

No data available for SIGNOR curated interactions for MTIF2 Gene

Drugs & Compounds for MTIF2 Gene

(2) Drugs for MTIF2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(6) Additional Compounds for MTIF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MTIF2: view

Transcripts for MTIF2 Gene

mRNA/cDNA for MTIF2 Gene

7 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTIF2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - -
SP2:
SP3: -
SP4: - -
SP5:
SP6: -

Relevant External Links for MTIF2 Gene

GeneLoc Exon Structure for
MTIF2

Expression for MTIF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MTIF2 Gene

Protein differential expression in normal tissues from HIPED for MTIF2 Gene

This gene is overexpressed in Lymph node (14.9), Peripheral blood mononuclear cells (9.6), and Salivary gland (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MTIF2 Gene



Protein tissue co-expression partners for MTIF2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MTIF2

SOURCE GeneReport for Unigene cluster for MTIF2 Gene:

Hs.149894

mRNA Expression by UniProt/SwissProt for MTIF2 Gene:

P46199-IF2M_HUMAN
Tissue specificity: Expressed in all tissues examined. Highest level in skeletal muscle.

Evidence on tissue expression from TISSUES for MTIF2 Gene

  • Liver(4.5)
  • Heart(4.3)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with MTIF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTIF2 Gene

Orthologs for MTIF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MTIF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTIF2 31 30
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MTIF2 31 30
  • 89.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MTIF2 31 30
  • 88.54 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtif2 30
  • 85.74 (n)
mouse
(Mus musculus)
Mammalia Mtif2 17 31 30
  • 85.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MTIF2 31
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTIF2 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTIF2 31 30
  • 70.99 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTIF2 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtif2 30
  • 66.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33073 30
zebrafish
(Danio rerio)
Actinopterygii mtif2 31 30
  • 61.74 (n)
OneToOne
wufb59c03 30
fruit fly
(Drosophila melanogaster)
Insecta CG12413 31 32 30
  • 52.32 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001670 30
  • 50.16 (n)
worm
(Caenorhabditis elegans)
Secernentea F46B6.6 31 32 30
  • 51.07 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IFM1 33 31
  • 34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G11160 30
  • 51.38 (n)
rice
(Oryza sativa)
Liliopsida Os09g0515500 30
  • 53.44 (n)
Os.17874 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.556 31
  • 46 (a)
OneToOne
Cin.15211 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15211 30
Species where no ortholog for MTIF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTIF2 Gene

ENSEMBL:
Gene Tree for MTIF2 (if available)
TreeFam:
Gene Tree for MTIF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MTIF2: view image

Paralogs for MTIF2 Gene

Pseudogenes.org Pseudogenes for MTIF2 Gene

genes like me logo Genes that share paralogs with MTIF2: view

Variants for MTIF2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MTIF2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs1281877795 Likely Pathogenic: Inborn genetic diseases 55,249,466(-) GCTCTTTTTTCA/G FRAMESHIFT_VARIANT
rs745980045 Uncertain Significance: Inborn genetic diseases 55,254,132(-) G/C MISSENSE_VARIANT,INTRON_VARIANT
rs1056445 - p.Thr59Asn
rs11357 - p.Val556Ile

Additional dbSNP identifiers (rs#s) for MTIF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MTIF2 Gene

Variant ID Type Subtype PubMed ID
esv2720078 CNV deletion 23290073
nsv522016 CNV gain 19592680
nsv525025 CNV loss 19592680

Variation tolerance for MTIF2 Gene

Residual Variation Intolerance Score: 19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTIF2 Gene

Human Gene Mutation Database (HGMD)
MTIF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTIF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTIF2 Gene

Disorders for MTIF2 Gene

Additional Disease Information for MTIF2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MTIF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTIF2 Gene

Publications for MTIF2 Gene

  1. Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA. (PMID: 7829522) Ma L … Spremulli LL (The Journal of biological chemistry 1995) 2 3 4 23 54
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  3. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick DM … Bierut L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41 54
  4. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PMID: 19209188) Reiling E … Dekker JM (European journal of human genetics : EJHG 2009) 3 41 54
  5. The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene. (PMID: 12932832) Overman RG … Farwell MA (Biochimica et biophysica acta 2003) 3 4 54

Products for MTIF2 Gene

Sources for MTIF2 Gene