Aliases for MTIF2 Gene
External Ids for MTIF2 Gene
Previous GeneCards Identifiers for MTIF2 Gene
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]
GeneCards Summary for MTIF2 Gene
MTIF2 (Mitochondrial Translational Initiation Factor 2) is a Protein Coding gene. Diseases associated with MTIF2 include Conduct Disorder and Deafness, Aminoglycoside-Induced. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is EIF5B.
UniProtKB/Swiss-Prot Summary for MTIF2 Gene
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.