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Aliases for MTG1 Gene

Aliases for MTG1 Gene

  • Mitochondrial Ribosome Associated GTPase 1 2 3 5
  • Mitochondrial Ribosome-Associated GTPase 1 2 3
  • GTP-Binding Protein 7 (Putative) 2 3
  • GTP-Binding Protein 7 2 4
  • GTPBP7 3 4
  • Mitochondrial GTPase 1 Homolog (S. Cerevisiae) 2
  • Mitochondrial GTPase 1 Homolog 3
  • Mitochondrial GTPase 1 4
  • GTP 3

External Ids for MTG1 Gene

Previous HGNC Symbols for MTG1 Gene

  • GTPBP7

Previous GeneCards Identifiers for MTG1 Gene

  • GC10P135099
  • GC10P135057
  • GC10P135207
  • GC10P128751

Summaries for MTG1 Gene

GeneCards Summary for MTG1 Gene

MTG1 (Mitochondrial Ribosome Associated GTPase 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ENSG00000254536.

UniProtKB/Swiss-Prot for MTG1 Gene

  • Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.

Gene Wiki entry for MTG1 Gene

Additional gene information for MTG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTG1 Gene

Genomics for MTG1 Gene

GeneHancer (GH) Regulatory Elements for MTG1 Gene

Promoters and enhancers for MTG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J133393 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 661.2 +0.6 561 2.4 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF213 MTG1 TUBGCP2 ENSG00000235245 OR6L1P RPL23AP60 SCART1 ZNF511 PAOX ENSG00000254536 SPRN
GH10J133400 Promoter/Enhancer 0.9 EPDnew ENCODE 650.4 +7.1 7080 1.5 JUNB BATF MTG1 SCART1 ENSG00000254536 SPRN
GH10J133398 Promoter 0.5 EPDnew 650.7 +4.3 4323 0.1 MTG1 ENSG00000254536 SPRN
GH10J132392 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 -985.7 -985692 32.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B NEUROD1 SIN3A YBX1 DMAP1 ZBTB7B PWWP2B TUBGCP2 ENSG00000235245 C10orf91 ZNF511 STK32C LOC105378568 PAOX PPP2R2D MTG1
GH10J133377 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.8 -15.2 -15218 2.3 ARID4B SIN3A DMAP1 ZNF2 ETS1 YY1 GLIS2 ZNF207 ZNF143 SP3 PAOX ECHS1 SCART1 MTG1 PIR35409
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MTG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MTG1 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • c-Myc
  • Max
  • Max1

Genomic Locations for MTG1 Gene

Genomic Locations for MTG1 Gene
chr10:133,394,094-133,421,307
(GRCh38/hg38)
Size:
27,214 bases
Orientation:
Plus strand
chr10:135,207,598-135,234,811
(GRCh37/hg19)
Size:
27,214 bases
Orientation:
Plus strand

Genomic View for MTG1 Gene

Genes around MTG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTG1 Gene

Proteins for MTG1 Gene

  • Protein details for MTG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT17-MTG1_HUMAN
    Recommended name:
    Mitochondrial ribosome-associated GTPase 1
    Protein Accession:
    Q9BT17
    Secondary Accessions:
    • Q5VWX8
    • Q6PIY9
    • Q8IYJ4
    • Q8NC48
    • Q9BVU8

    Protein attributes for MTG1 Gene

    Size:
    334 amino acids
    Molecular mass:
    37237 Da
    Quaternary structure:
    • Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent manner (PubMed:23396448).
    SequenceCaution:
    • Sequence=AAH04409.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH35721.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTG1 Gene

Post-translational modifications for MTG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTG1 Gene

Domains & Families for MTG1 Gene

Gene Families for MTG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MTG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BT17

UniProtKB/Swiss-Prot:

MTG1_HUMAN :
  • Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
Family:
  • Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
genes like me logo Genes that share domains with MTG1: view

Function for MTG1 Gene

Molecular function for MTG1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.

Phenotypes From GWAS Catalog for MTG1 Gene

Gene Ontology (GO) - Molecular Function for MTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 23396448
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with MTG1: view
genes like me logo Genes that share phenotypes with MTG1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTG1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTG1 Gene

Localization for MTG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTG1 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTG1 gene
Compartment Confidence
mitochondrion 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA,IEA --
GO:0005743 mitochondrial inner membrane IDA,IEA 23396448
GO:0005759 mitochondrial matrix IDA 23396448
GO:0005761 mitochondrial ribosome IDA 23396448
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MTG1: view

Pathways & Interactions for MTG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0042254 ribosome biogenesis IBA --
GO:0044065 regulation of respiratory system process IMP 23396448
GO:0070129 regulation of mitochondrial translation IMP 23396448
genes like me logo Genes that share ontologies with MTG1: view

No data available for Pathways by source and SIGNOR curated interactions for MTG1 Gene

Drugs & Compounds for MTG1 Gene

(1) Drugs for MTG1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with MTG1: view

Transcripts for MTG1 Gene

mRNA/cDNA for MTG1 Gene

(1) REFSEQ mRNAs :
(40) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTG1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTG1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - -
SP6:
SP7: -
SP8: - - -

Relevant External Links for MTG1 Gene

GeneLoc Exon Structure for
MTG1
ECgene alternative splicing isoforms for
MTG1

Expression for MTG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTG1 Gene

Protein differential expression in normal tissues from HIPED for MTG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.5), Kidney (15.2), and Ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MTG1 Gene



Protein tissue co-expression partners for MTG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTG1 Gene:

MTG1

Evidence on tissue expression from TISSUES for MTG1 Gene

  • Pancreas(4)
  • Skin(4)
genes like me logo Genes that share expression patterns with MTG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTG1 Gene

Orthologs for MTG1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MTG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTG1 34 33
  • 99.4 (n)
OneToMany
cow
(Bos Taurus)
Mammalia MTG1 34 33
  • 85.94 (n)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mtg1 33
  • 81.11 (n)
mouse
(Mus musculus)
Mammalia Mtg1 16 34 33
  • 79.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
ManyToMany
-- 34
  • 67 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MTG1 34 33
  • 67.1 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mtg1 33
  • 66.67 (n)
Str.15410 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15705 33
zebrafish
(Danio rerio)
Actinopterygii gtpbpl 34 33 33
  • 61.02 (n)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13992 33
fruit fly
(Drosophila melanogaster)
Insecta CG17141 34 33
  • 54.3 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004736 33
  • 51.31 (n)
worm
(Caenorhabditis elegans)
Secernentea Y67D2.4 34 33
  • 47.21 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTG1 36 34 33
  • 44.25 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL048W 33
  • 43.46 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F02904g 33
  • 41.49 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02123 33
  • 45.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mtg1 33
  • 42.09 (n)
Species where no ortholog for MTG1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTG1 Gene

ENSEMBL:
Gene Tree for MTG1 (if available)
TreeFam:
Gene Tree for MTG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MTG1: view image

Paralogs for MTG1 Gene

Paralogs for MTG1 Gene

genes like me logo Genes that share paralogs with MTG1: view

Variants for MTG1 Gene

Sequence variations from dbSNP and Humsavar for MTG1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000059681 -- 133,407,142(+) C/A intron_variant
rs1000126153 -- 133,419,351(+) G/A intron_variant
rs1000245596 -- 133,399,687(+) C/T intron_variant
rs1000275977 -- 133,412,958(+) G/C intron_variant
rs1000496844 -- 133,394,824(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MTG1 Gene

Variant ID Type Subtype PubMed ID
nsv952708 CNV deletion 24416366
nsv952707 CNV deletion 24416366
nsv832041 CNV gain 17160897
nsv832040 CNV loss 17160897
nsv7631 CNV deletion 18451855
nsv552644 CNV loss 21841781
nsv552589 CNV gain 21841781
nsv528260 CNV loss 19592680
nsv527785 CNV loss 19592680
nsv517180 CNV gain+loss 19592680
nsv514545 CNV gain 21397061
nsv470981 CNV gain 18288195
nsv470980 CNV loss 18288195
nsv469597 CNV gain 16826518
nsv467509 CNV loss 19166990
nsv428243 CNV gain 18775914
nsv1052904 CNV gain 25217958
nsv1052033 CNV gain 25217958
nsv1043323 CNV gain 25217958
nsv1037772 CNV gain 25217958
esv3625045 CNV gain 21293372
esv3579239 CNV loss 25503493
esv2764146 CNV gain+loss 21179565
esv2760130 CNV gain+loss 21179565
esv2759793 CNV gain+loss 17122850
esv2750853 CNV gain 17911159
dgv999n100 CNV gain 25217958
dgv3e196 CNV duplication 17116639
dgv39n111 CNV duplication 26073780
dgv35e55 CNV gain 17911159
dgv304e212 CNV gain 25503493
dgv2e196 CNV duplication 17116639
dgv1489n54 CNV gain 21841781
dgv1488n54 CNV gain 21841781
dgv1487n54 CNV gain 21841781
dgv1486n54 CNV gain 21841781
dgv125n27 CNV gain 19166990
dgv124n27 CNV gain 19166990
dgv123n27 CNV gain 19166990
dgv1001n100 CNV gain 25217958
dgv1000n100 CNV gain 25217958

Variation tolerance for MTG1 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTG1 Gene

Disorders for MTG1 Gene

Additional Disease Information for MTG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MTG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTG1 Gene

Publications for MTG1 Gene

  1. Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes. (PMID: 23396448) Kotani T … Takeuchi N (Nucleic acids research 2013) 2 3 4 58
  2. MTG1 codes for a conserved protein required for mitochondrial translation. (PMID: 12808030) Barrientos A … Tzagoloff A (Molecular biology of the cell 2003) 2 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58

Products for MTG1 Gene

Sources for MTG1 Gene

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