Aliases for MTF2 Gene
External Ids for MTF2 Gene
Previous GeneCards Identifiers for MTF2 Gene
GeneCards Summary for MTF2 Gene
MTF2 (Metal Response Element Binding Transcription Factor 2) is a Protein Coding gene. Diseases associated with MTF2 include Hereditary Lymphedema I. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include methylated histone binding. An important paralog of this gene is PHF19.
UniProtKB/Swiss-Prot Summary for MTF2 Gene
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).