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Aliases for MTERF2 Gene

Aliases for MTERF2 Gene

  • Mitochondrial Transcription Termination Factor 2 2 3 4 5
  • Mitochondrial Transcription Termination Factor-Like Protein 3 4
  • MTERF Domain-Containing Protein 3, Mitochondrial 3 4
  • MTERF Domain Containing 3 2 3
  • MTERF-Like 3 4
  • MTERFD3 3 4
  • MTERFL 3 4
  • Transcription Termination Factor 2, Mitochondrial 3
  • MTERF2 4

External Ids for MTERF2 Gene

Previous HGNC Symbols for MTERF2 Gene


Summaries for MTERF2 Gene

GeneCards Summary for MTERF2 Gene

MTERF2 (Mitochondrial Transcription Termination Factor 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and double-stranded DNA binding. An important paralog of this gene is MTERF1.

UniProtKB/Swiss-Prot for MTERF2 Gene

  • Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species.

Additional gene information for MTERF2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTERF2 Gene

Genomics for MTERF2 Gene

GeneHancer (GH) Regulatory Elements for MTERF2 Gene

Promoters and enhancers for MTERF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J106984 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 658.1 +0.6 638 3.3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B MTERF2 GC12P106984 ENSG00000260329 CRY1
GH12J106073 Enhancer 1.4 Ensembl ENCODE dbSUPER 37.1 +907.5 907468 12.6 PKNOX1 ARNT FEZF1 ZNF2 IRF4 YY1 ZNF213 FOS JUNB ZNF662 MTERF2 RPL30P12 LOC100287944 ENSG00000260329 ENSG00000257890 CKAP4 GC12M106085 NUAK1
GH12J107090 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13.2 -105.8 -105807 4.3 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B CRY1 ENSG00000257548 RPL30P12 LOC644746 PWP1 LOC101929162 MTERF2 PRDM4 ENSG00000257398 PIR33339
GH12J106299 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +684.8 684809 5.7 PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 IRF4 YY1 TCP11L2 CKAP4 ENSG00000260329 POLR3B MTERF2 TMEM263
GH12J106954 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 +31.1 31059 4.2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF213 ENSG00000260329 TMEM263 GC12M106953 PRDM4 PWP1 MTERF2 GC12P106984
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MTERF2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MTERF2 Gene

Genomic Locations for MTERF2 Gene
9,876 bases
Minus strand

Genomic View for MTERF2 Gene

Genes around MTERF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTERF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTERF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTERF2 Gene

Proteins for MTERF2 Gene

  • Protein details for MTERF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription termination factor 2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q53HM2
    • Q9H4L6
    • Q9H7Y9

    Protein attributes for MTERF2 Gene

    385 amino acids
    Molecular mass:
    44414 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for MTERF2 Gene

Post-translational modifications for MTERF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTERF2 Gene

Domains & Families for MTERF2 Gene

Gene Families for MTERF2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MTERF2 Gene


Suggested Antigen Peptide Sequences for MTERF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mTERF family.
  • Belongs to the mTERF family.
genes like me logo Genes that share domains with MTERF2: view

Function for MTERF2 Gene

Molecular function for MTERF2 Gene

UniProtKB/Swiss-Prot Function:
Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species.

Phenotypes From GWAS Catalog for MTERF2 Gene

Gene Ontology (GO) - Molecular Function for MTERF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IBA --
GO:0003677 DNA binding IDA 19366608
GO:0003690 double-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with MTERF2: view
genes like me logo Genes that share phenotypes with MTERF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTERF2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MTERF2 Gene

Localization for MTERF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTERF2 Gene

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTERF2 gene
Compartment Confidence
mitochondrion 5
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MTERF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 19366608
GO:0005759 mitochondrial matrix IBA --
GO:0042645 mitochondrial nucleoid ISS --
genes like me logo Genes that share ontologies with MTERF2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTERF2 Gene

Pathways & Interactions for MTERF2 Gene

SuperPathways for MTERF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTERF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006393 termination of mitochondrial transcription IBA --
genes like me logo Genes that share ontologies with MTERF2: view

No data available for Pathways by source and SIGNOR curated interactions for MTERF2 Gene

Drugs & Compounds for MTERF2 Gene

No Compound Related Data Available

Transcripts for MTERF2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTERF2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTERF2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: - - -
SP3: -
SP4: - - - - -

Relevant External Links for MTERF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTERF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTERF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTERF2 Gene:


mRNA Expression by UniProt/SwissProt for MTERF2 Gene:

Tissue specificity: Expressed in skeletal muscle, heart, liver and pancreas.

Evidence on tissue expression from TISSUES for MTERF2 Gene

  • Nervous system(4.3)
  • Bone marrow(4.1)
  • Lymph node(4.1)
genes like me logo Genes that share expression patterns with MTERF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTERF2 Gene

Orthologs for MTERF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTERF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTERFD3 34 33
  • 99.65 (n)
(Bos Taurus)
Mammalia MTERFD3 34 33
  • 90.56 (n)
(Canis familiaris)
Mammalia MTERFD3 34
  • 87 (a)
(Mus musculus)
Mammalia Mterfd3 34 33
  • 80.09 (n)
Mterf2 16
(Rattus norvegicus)
Mammalia Mterfd3 33
  • 79.39 (n)
(Monodelphis domestica)
Mammalia MTERFD3 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia MTERFD3 34
  • 65 (a)
(Gallus gallus)
Aves MTERFD3 34 33
  • 68.71 (n)
(Anolis carolinensis)
Reptilia MTERFD3 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485703 33
  • 61.14 (n)
(Danio rerio)
Actinopterygii mterfd3 34 33
  • 54 (n)
Species where no ortholog for MTERF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTERF2 Gene

Gene Tree for MTERF2 (if available)
Gene Tree for MTERF2 (if available)
Evolutionary constrained regions (ECRs) for MTERF2: view image

Paralogs for MTERF2 Gene

Paralogs for MTERF2 Gene

genes like me logo Genes that share paralogs with MTERF2: view

Variants for MTERF2 Gene

Sequence variations from dbSNP and Humsavar for MTERF2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000156561 -- 106,983,173(-) A/C intron_variant
rs1000264003 -- 106,982,680(-) T/G intron_variant
rs1000446463 -- 106,982,767(-) G/A intron_variant
rs1001717459 -- 106,984,460(-) A/T intron_variant
rs1001852877 -- 106,977,491(-) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MTERF2 Gene

Variant ID Type Subtype PubMed ID
nsv437155 CNV loss 16327808

Variation tolerance for MTERF2 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTERF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTERF2 Gene

Disorders for MTERF2 Gene

Additional Disease Information for MTERF2

No disorders were found for MTERF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTERF2 Gene

Publications for MTERF2 Gene

  1. MTERF2 is a nucleoid component in mammalian mitochondria. (PMID: 19366608) Pellegrini M … Gustafsson CM (Biochimica et biophysica acta 2009) 2 3 4 58
  2. Cloning and functional analysis of human mTERFL encoding a novel mitochondrial transcription termination factor-like protein. (PMID: 16226716) Chen Y … Tan D (Biochemical and biophysical research communications 2005) 3 4 22 58
  3. A family of putative transcription termination factors shared amongst metazoans and plants. (PMID: 16193327) Linder T … Gustafsson CM (Current genetics 2005) 2 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MTERF2 Gene

Sources for MTERF2 Gene

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