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Aliases for MTDH Gene

Aliases for MTDH Gene

  • Metadherin 2 3 4 5
  • Lysine-Rich CEACAM1 Co-Isolated Protein 3 4
  • Astrocyte Elevated Gene-1 Protein 3 4
  • Metastasis Adhesion Protein 3 4
  • Astrocyte Elevated Gene 1 2 3
  • 3D3/LYRIC 3 4
  • AEG-1 3 4
  • LYRIC 3 4
  • AEG1 3 4
  • Protein LYRIC 3
  • LYRIC/3D3 3
  • 3D3 3

External Ids for MTDH Gene

Previous GeneCards Identifiers for MTDH Gene

  • GC08P098726
  • GC08P093862
  • GC08P098658

Summaries for MTDH Gene

GeneCards Summary for MTDH Gene

MTDH (Metadherin) is a Protein Coding gene. Diseases associated with MTDH include Gallbladder Adenocarcinoma and Nervous System Disease. Among its related pathways are Validated targets of C-MYC transcriptional activation and Gastric Cancer Network 2. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding.

UniProtKB/Swiss-Prot for MTDH Gene

  • Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

Gene Wiki entry for MTDH Gene

Additional gene information for MTDH Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTDH Gene

Genomics for MTDH Gene

GeneHancer (GH) Regulatory Elements for MTDH Gene

Promoters and enhancers for MTDH Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I097642 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 565.4 +1.2 1197 5.3 HDGF PKNOX1 CLOCK FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B MTDH ENSG00000245970 LAPTM4B ENSG00000202399 GC08P097773
GH08I097595 Enhancer 0.9 Ensembl ENCODE 17.1 -48.1 -48100 0.3 ELF3 CTCF ZNF449 RAD21 YY1 ZNF335 GATA3 ZNF143 SMC3 RCOR1 MTDH RPS2P33 LOC105375657
GH08I097606 Enhancer 0.7 Ensembl ENCODE 16.1 -36.8 -36794 0.9 NFIC PRDM6 POLR2A ZNF10 CHD2 MTDH LAPTM4B ENSG00000202399 RPS2P33 LOC105375657
GH08I097774 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.8 +133.0 133026 5 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 POLR2B ZNF766 SP3 LAPTM4B MTDH ENSG00000270682
GH08I097597 Enhancer 0.7 Ensembl ENCODE 12.1 -45.6 -45646 1.4 RNF2 IKZF1 NBN MLLT1 ZBTB40 IKZF2 MYC MTDH LAPTM4B RPS2P33 LOC105375657
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MTDH on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MTDH gene promoter:

Genomic Locations for MTDH Gene

Genomic Locations for MTDH Gene
chr8:97,644,147-97,730,260
(GRCh38/hg38)
Size:
86,114 bases
Orientation:
Plus strand
chr8:98,656,407-98,742,488
(GRCh37/hg19)

Genomic View for MTDH Gene

Genes around MTDH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTDH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTDH Gene

Proteins for MTDH Gene

  • Protein details for MTDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UE4-LYRIC_HUMAN
    Recommended name:
    Protein LYRIC
    Protein Accession:
    Q86UE4
    Secondary Accessions:
    • Q05DH2
    • Q52QU9
    • Q6PK07
    • Q8TCX3

    Protein attributes for MTDH Gene

    Size:
    582 amino acids
    Molecular mass:
    63837 Da
    Quaternary structure:
    • Interacts with BCCIP, CREBBP/CBP and RELA/p65.
    Miscellaneous:
    • Knockdown significantly reduces the adhesion of cancer cells to lung microvascular endothelial cells and the reciprocal effect is observed following overexpression.

    Three dimensional structures from OCA and Proteopedia for MTDH Gene

neXtProt entry for MTDH Gene

Post-translational modifications for MTDH Gene

  • Ubiquitination at isoforms=1, 2, 1, 2, 1, 2, 1, 2, 1, 2, 1, 2, 1, 2, 1, 2107
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MTDH Gene

Domains & Families for MTDH Gene

Gene Families for MTDH Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MTDH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTDH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MTDH: view

No data available for UniProtKB/Swiss-Prot for MTDH Gene

Function for MTDH Gene

Molecular function for MTDH Gene

UniProtKB/Swiss-Prot Function:
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
UniProtKB/Swiss-Prot Induction:
By TNF (at protein level). By HIV-1 infection of primary fetal astrocytes.

Phenotypes From GWAS Catalog for MTDH Gene

Gene Ontology (GO) - Molecular Function for MTDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IPI 18316612
GO:0003713 transcription coactivator activity IMP 18316612
GO:0003723 RNA binding IDA,HDA 22658674
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0005515 protein binding IPI 18316612
genes like me logo Genes that share ontologies with MTDH: view
genes like me logo Genes that share phenotypes with MTDH: view

Animal Models for MTDH Gene

MGI Knock Outs for MTDH:

Animal Model Products

CRISPR Products

miRNA for MTDH Gene

miRTarBase miRNAs that target MTDH

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MTDH

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTDH Gene

Localization for MTDH Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTDH Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Cell junction, tight junction. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTDH gene
Compartment Confidence
plasma membrane 5
nucleus 5
endoplasmic reticulum 5
cytosol 2
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MTDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA,IEA 16452207
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA,IDA 19648967
GO:0005783 endoplasmic reticulum IDA 14980505
genes like me logo Genes that share ontologies with MTDH: view

Pathways & Interactions for MTDH Gene

genes like me logo Genes that share pathways with MTDH: view

Pathways by source for MTDH Gene

1 GeneGo (Thomson Reuters) pathway for MTDH Gene
1 Cell Signaling Technology pathway for MTDH Gene

Gene Ontology (GO) - Biological Process for MTDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 15927426
GO:0010508 positive regulation of autophagy IDA 21127263
GO:0031663 lipopolysaccharide-mediated signaling pathway IMP 19740331
GO:0043066 negative regulation of apoptotic process IEA,IDA 17704808
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA,IDA 16452207
genes like me logo Genes that share ontologies with MTDH: view

No data available for SIGNOR curated interactions for MTDH Gene

Drugs & Compounds for MTDH Gene

(2) Additional Compounds for MTDH Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MTDH: view

Transcripts for MTDH Gene

Unigene Clusters for MTDH Gene

Metadherin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MTDH

Alternative Splicing Database (ASD) splice patterns (SP) for MTDH Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1:
SP2: -
SP3:

Relevant External Links for MTDH Gene

GeneLoc Exon Structure for
MTDH
ECgene alternative splicing isoforms for
MTDH

Expression for MTDH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTDH Gene

Protein differential expression in normal tissues from HIPED for MTDH Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTDH Gene



Protein tissue co-expression partners for MTDH Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MTDH Gene:

MTDH

SOURCE GeneReport for Unigene cluster for MTDH Gene:

Hs.377155

mRNA Expression by UniProt/SwissProt for MTDH Gene:

Q86UE4-LYRIC_HUMAN
Tissue specificity: Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.

Evidence on tissue expression from TISSUES for MTDH Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Skin(4.6)
  • Blood(4.3)
  • Intestine(3.5)
  • Kidney(3.2)
  • Lung(3.1)
  • Lymph node(2.6)
  • Pancreas(2.4)
  • Gall bladder(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with MTDH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTDH Gene

Orthologs for MTDH Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTDH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTDH 34 33
  • 99.71 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MTDH 34 33
  • 93.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MTDH 34 33
  • 92.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mtdh 34 16 33
  • 90.62 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtdh 33
  • 90.3 (n)
oppossum
(Monodelphis domestica)
Mammalia MTDH 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTDH 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTDH 33 34
  • 72.83 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mtdh 33
  • 62.21 (n)
MGC75963 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25186 33
zebrafish
(Danio rerio)
Actinopterygii mtdha 33 34
  • 52.45 (n)
mtdhb 34
  • 35 (a)
OneToMany
Species where no ortholog for MTDH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTDH Gene

ENSEMBL:
Gene Tree for MTDH (if available)
TreeFam:
Gene Tree for MTDH (if available)

Paralogs for MTDH Gene

No data available for Paralogs for MTDH Gene

Variants for MTDH Gene

Sequence variations from dbSNP and Humsavar for MTDH Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000027040 -- 97,707,181(+) TTGTTGT/TTGT intron_variant
rs1000140275 -- 97,725,623(+) A/G 3_prime_UTR_variant
rs1000157366 -- 97,644,271(+) C/T 5_prime_UTR_variant
rs1000160072 -- 97,718,915(+) C/T intron_variant
rs1000161862 -- 97,665,276(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MTDH Gene

Variant ID Type Subtype PubMed ID
esv2752271 CNV gain 17911159
esv3543904 CNV deletion 23714750
nsv1017596 CNV gain 25217958
nsv526913 CNV loss 19592680
nsv6325 CNV deletion 18451855

Variation tolerance for MTDH Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTDH Gene

Human Gene Mutation Database (HGMD)
MTDH
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTDH

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTDH Gene

Disorders for MTDH Gene

MalaCards: The human disease database

(4) MalaCards diseases for MTDH Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gallbladder adenocarcinoma
  • adenocarcinoma of the gallbladder
nervous system disease
  • abnormality of the nervous system
glioblastoma multiforme
  • adult glioblastoma multiforme
central nervous system disease
  • cns
- elite association - COSMIC cancer census association via MalaCards
Search MTDH in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MTDH

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MTDH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTDH Gene

Publications for MTDH Gene

  1. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. (PMID: 15093543) Brown DM … Ruoslahti E (Cancer cell 2004) 2 3 4 22 58
  2. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. (PMID: 19111877) Hu G … Kang Y (Cancer cell 2009) 3 4 22 58
  3. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. (PMID: 18316612) Sarkar D … Fisher PB (Cancer research 2008) 3 4 22 58
  4. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. (PMID: 16452207) Emdad L … Fisher PB (Cancer research 2006) 3 4 22 58
  5. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. (PMID: 15927426) Kang DC … Fisher PB (Gene 2005) 3 4 22 58

Products for MTDH Gene

  • Addgene plasmids for MTDH

Sources for MTDH Gene

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