Aliases for MTDH Gene

Aliases for MTDH Gene

  • Metadherin 2 3 4 5
  • AEG-1 2 3 4
  • LYRIC 2 3 4
  • Lysine-Rich CEACAM1 Co-Isolated Protein 3 4
  • Astrocyte Elevated Gene-1 Protein 3 4
  • Metastasis Adhesion Protein 3 4
  • Astrocyte Elevated Gene 1 2 3
  • Protein LYRIC 3 4
  • 3D3/LYRIC 3 4
  • AEG1 3 4
  • 3D3 2 3
  • LYRIC/3D3 3
  • MTDH 5

External Ids for MTDH Gene

Previous GeneCards Identifiers for MTDH Gene

  • GC08P098726
  • GC08P093862
  • GC08P098658
  • GC08P097644

Summaries for MTDH Gene

GeneCards Summary for MTDH Gene

MTDH (Metadherin) is a Protein Coding gene. Diseases associated with MTDH include Tongue Carcinoma and Gallbladder Adenocarcinoma. Among its related pathways are Validated targets of C-MYC transcriptional activation and Gastric Cancer Network 2. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is MAMSTR.

UniProtKB/Swiss-Prot Summary for MTDH Gene

  • Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

Gene Wiki entry for MTDH Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MTDH Gene

Genomics for MTDH Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around MTDH on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MTDH

Top Transcription factor binding sites by QIAGEN in the MTDH gene promoter:
  • aMEF-2
  • AP-1
  • ATF
  • ATF-2
  • c-Jun
  • Egr-4
  • FOXO1
  • GR
  • GR-alpha
  • MEF-2A

Genomic Locations for MTDH Gene

Latest Assembly
chr8:97,643,972-97,730,260
(GRCh38/hg38)
Size:
86,289 bases
Orientation:
Plus strand

Previous Assembly
chr8:98,656,412-98,742,488
(GRCh37/hg19 by Entrez Gene)
Size:
86,077 bases
Orientation:
Plus strand

chr8:98,656,407-98,740,998
(GRCh37/hg19 by Ensembl)
Size:
84,592 bases
Orientation:
Plus strand

Genomic View for MTDH Gene

Genes around MTDH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTDH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTDH Gene

Proteins for MTDH Gene

  • Protein details for MTDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UE4-LYRIC_HUMAN
    Recommended name:
    Protein LYRIC
    Protein Accession:
    Q86UE4
    Secondary Accessions:
    • Q05DH2
    • Q52QU9
    • Q6PK07
    • Q8TCX3

    Protein attributes for MTDH Gene

    Size:
    582 amino acids
    Molecular mass:
    63837 Da
    Quaternary structure:
    • Interacts with BCCIP, CREBBP/CBP and RELA/p65.
    Miscellaneous:
    • Knockdown significantly reduces the adhesion of cancer cells to lung microvascular endothelial cells and the reciprocal effect is observed following overexpression.

    Three dimensional structures from OCA and Proteopedia for MTDH Gene

neXtProt entry for MTDH Gene

Post-translational modifications for MTDH Gene

  • Ubiquitination at Lys107
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for MTDH

No data available for DME Specific Peptides for MTDH Gene

Domains & Families for MTDH Gene

Gene Families for MTDH Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MTDH Gene

InterPro:

Suggested Antigen Peptide Sequences for MTDH Gene

GenScript: Design optimal peptide antigens:
  • Metastasis adhesion protein (LYRIC_HUMAN)
genes like me logo Genes that share domains with MTDH: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MTDH Gene

Function for MTDH Gene

Molecular function for MTDH Gene

UniProtKB/Swiss-Prot Function:
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
UniProtKB/Swiss-Prot Induction:
By TNF (at protein level). By HIV-1 infection of primary fetal astrocytes.

Phenotypes From GWAS Catalog for MTDH Gene

Gene Ontology (GO) - Molecular Function for MTDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IPI 18316612
GO:0003712 transcription coregulator activity IBA 21873635
GO:0003713 transcription coactivator activity IMP 18316612
GO:0003723 RNA binding HDA 22658674
GO:0003725 double-stranded RNA binding IDA 21266579
genes like me logo Genes that share ontologies with MTDH: view
genes like me logo Genes that share phenotypes with MTDH: view

Animal Models for MTDH Gene

MGI Knock Outs for MTDH:
  • Mtdh Mtdh<tm1.2Dsar>

miRNA for MTDH Gene

miRTarBase miRNAs that target MTDH

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTDH

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTDH Gene

Localization for MTDH Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTDH Gene

Endoplasmic reticulum membrane. Single-pass membrane protein. Nucleus membrane. Single-pass membrane protein. Cell junction, tight junction. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTDH gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
plasma membrane 4
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MTDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IBA,IDA 16452207
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA,IDA 19648967
GO:0005783 endoplasmic reticulum IDA 14980505
genes like me logo Genes that share ontologies with MTDH: view

Pathways & Interactions for MTDH Gene

genes like me logo Genes that share pathways with MTDH: view

Pathways by source for MTDH Gene

1 GeneGo (Thomson Reuters) pathway for MTDH Gene
  • Cell adhesion Tight junctions
1 Cell Signaling Technology pathway for MTDH Gene

Gene Ontology (GO) - Biological Process for MTDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 15927426
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0010508 positive regulation of autophagy IDA 21127263
GO:0031663 lipopolysaccharide-mediated signaling pathway IMP 19740331
GO:0043066 negative regulation of apoptotic process IEA,IDA 17704808
genes like me logo Genes that share ontologies with MTDH: view

No data available for SIGNOR curated interactions for MTDH Gene

Drugs & Compounds for MTDH Gene

(2) Additional Compounds for MTDH Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MTDH: view

Transcripts for MTDH Gene

mRNA/cDNA for MTDH Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTDH

Alternative Splicing Database (ASD) splice patterns (SP) for MTDH Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1:
SP2: -
SP3:

Relevant External Links for MTDH Gene

GeneLoc Exon Structure for
MTDH

Expression for MTDH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MTDH Gene

Protein differential expression in normal tissues from HIPED for MTDH Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MTDH Gene



Protein tissue co-expression partners for MTDH Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MTDH

SOURCE GeneReport for Unigene cluster for MTDH Gene:

Hs.377155

mRNA Expression by UniProt/SwissProt for MTDH Gene:

Q86UE4-LYRIC_HUMAN
Tissue specificity: Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.

Evidence on tissue expression from TISSUES for MTDH Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Skin(4.7)
  • Blood(4.4)
  • Intestine(3.6)
  • Kidney(3.3)
  • Lung(3.3)
  • Pancreas(3)
  • Lymph node(2.8)
  • Heart(2.5)
  • Stomach(2.3)
  • Spleen(2.3)
  • Thyroid gland(2.3)
  • Muscle(2.2)
  • Bone marrow(2.2)
  • Gall bladder(2.2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with MTDH: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTDH Gene

Orthologs for MTDH Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTDH Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MTDH 29 30
  • 99.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MTDH 29 30
  • 93.7 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MTDH 29 30
  • 92.61 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mtdh 29 16 30
  • 90.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mtdh 29
  • 90.3 (n)
Oppossum
(Monodelphis domestica)
Mammalia MTDH 30
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MTDH 30
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MTDH 29 30
  • 72.83 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 55 (a)
OneToMany
-- 30
  • 52 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mtdh 29
  • 62.21 (n)
MGC75963 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.25186 29
Zebrafish
(Danio rerio)
Actinopterygii mtdha 29 30
  • 52.45 (n)
OneToMany
mtdhb 30
  • 35 (a)
OneToMany
Species where no ortholog for MTDH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MTDH Gene

ENSEMBL:
Gene Tree for MTDH (if available)
TreeFam:
Gene Tree for MTDH (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MTDH: view image
Alliance of Genome Resources:
Additional Orthologs for MTDH

Paralogs for MTDH Gene

Paralogs for MTDH Gene

genes like me logo Genes that share paralogs with MTDH: view

Variants for MTDH Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MTDH Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs117026063 Benign: not provided 97,724,594(+) T/C
NM_178812.4(MTDH):c.1679-6T>C
INTRON
rs140652237 Benign: not provided 97,644,666(+) G/A
NM_178812.4(MTDH):c.160G>A (p.Val54Met)
MISSENSE
rs17854374 -- p.Thr317Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MTDH Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MTDH Gene

Variant ID Type Subtype PubMed ID
esv2752271 CNV gain 17911159
esv3543904 CNV deletion 23714750
nsv1017596 CNV gain 25217958
nsv526913 CNV loss 19592680
nsv6325 CNV deletion 18451855

Variation tolerance for MTDH Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTDH Gene

Human Gene Mutation Database (HGMD)
MTDH
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTDH
Leiden Open Variation Database (LOVD)
MTDH

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTDH Gene

Disorders for MTDH Gene

MalaCards: The human disease database

(16) MalaCards diseases for MTDH Gene - From: COP and GCD

Disorder Aliases PubMed IDs
tongue carcinoma
  • tongue cancer
gallbladder adenocarcinoma
  • adenocarcinoma of the gallbladder
nervous system disease
  • abnormality of the nervous system
central nervous system disease
  • cns
salivary gland carcinoma
  • salivary gland cancer
- elite association - COSMIC cancer census association via MalaCards
Search MTDH in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MTDH

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MTDH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTDH Gene

Publications for MTDH Gene

  1. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. (PMID: 15093543) Brown DM … Ruoslahti E (Cancer cell 2004) 2 3 4 22
  2. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. (PMID: 19111877) Hu G … Kang Y (Cancer cell 2009) 3 4 22
  3. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. (PMID: 18316612) Sarkar D … Fisher PB (Cancer research 2008) 3 4 22
  4. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. (PMID: 16452207) Emdad L … Fisher PB (Cancer research 2006) 3 4 22
  5. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. (PMID: 15927426) Kang DC … Fisher PB (Gene 2005) 3 4 22

Products for MTDH Gene

Sources for MTDH Gene