Aliases for MTCH2 Gene
External Ids for MTCH2 Gene
Previous GeneCards Identifiers for MTCH2 Gene
This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]
GeneCards Summary for MTCH2 Gene
MTCH2 (Mitochondrial Carrier 2) is a Protein Coding gene. An important paralog of this gene is MTCH1.
UniProtKB/Swiss-Prot for MTCH2 Gene
The substrate transported is not yet known. Induces mitochondrial depolarization.