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Aliases for MTCH2 Gene

Aliases for MTCH2 Gene

  • Mitochondrial Carrier 2 2 3 5
  • Solute Carrier Family 25, Member 50 2 3
  • Met-Induced Mitochondrial Protein 3 4
  • MIMP 3 4
  • Mitochondrial Carrier Homolog 2 (C. Elegans) 2
  • Mitochondrial Carrier Homolog 2 3
  • 2310034D24Rik 3
  • SLC25A50 3
  • HSPC032 3

External Ids for MTCH2 Gene

Previous GeneCards Identifiers for MTCH2 Gene

  • GC11U990208
  • GC11M048517
  • GC11M047670
  • GC11M047604
  • GC11M047600
  • GC11M047595
  • GC11M047639
  • GC11M047341
  • GC11M047745
  • GC11M048081
  • GC11M048804
  • GC11M049909
  • GC11M047855
  • GC11M047959
  • GC11M050806
  • GC11M051601
  • GC11M052263
  • GC11M052923
  • GC11M053591

Summaries for MTCH2 Gene

Entrez Gene Summary for MTCH2 Gene

  • This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]

GeneCards Summary for MTCH2 Gene

MTCH2 (Mitochondrial Carrier 2) is a Protein Coding gene. An important paralog of this gene is MTCH1.

UniProtKB/Swiss-Prot for MTCH2 Gene

  • The substrate transported is not yet known. Induces mitochondrial depolarization.

Gene Wiki entry for MTCH2 Gene

Additional gene information for MTCH2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTCH2 Gene

Genomics for MTCH2 Gene

GeneHancer (GH) Regulatory Elements for MTCH2 Gene

Promoters and enhancers for MTCH2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I047640 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.4 390 3 HDGF PKNOX1 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 MTCH2 C1QTNF4 NUP160 FNBP4 ENSG00000270060 ZNF408 DDB2 PACSIN3 LRP4-AS1 GC11M055369
GH11I047506 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +129.1 129073 14.4 HDGF PKNOX1 ZFP64 ZNF213 FOS JUNB ZC3H11A REST SREBF1 SMARCA4 ENSG00000270072 NUP160 FNBP4 ENSG00000200090 ENSG00000270060 C1QTNF4 ZNF408 DDB2 AMBRA1 CELF1
GH11I047853 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.8 -216.9 -216898 12.4 PKNOX1 IRF4 BRCA1 GTF3C2 TCF12 ZNF143 ATF7 FOS RUNX3 DEK C1QTNF4 MADD ARFGAP2 MYBPC3 KBTBD4 MTCH2 FNBP4 PTPRJ PACSIN3 NUP160
GH11I047537 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.8 +103.3 103261 4.4 PKNOX1 INSM2 KLF17 SIN3A FEZF1 ZNF2 RAD21 ZNF335 ZNF366 SCRT2 C1QTNF4 CELF1 NDUFS3 PTPMT1 KBTBD4 RNU5E-10P ENSG00000231880 MADD MTCH2 FNBP4
GH11I047498 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.3 +143.2 143169 1.4 FOXA2 TAF1 NFIB MAX RAD21 YY1 GATA3 POLR2A HNF4G PRDM10 NDUFS3 PTPMT1 CELF1 RAPSN ENSG00000231880 KBTBD4 RNU5E-10P FAM180B C1QTNF4 MTCH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MTCH2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MTCH2 gene promoter:

Genomic Locations for MTCH2 Gene

Genomic Locations for MTCH2 Gene
37,451 bases
Minus strand

Genomic View for MTCH2 Gene

Genes around MTCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTCH2 Gene

Proteins for MTCH2 Gene

  • Protein details for MTCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial carrier homolog 2
    Protein Accession:
    Secondary Accessions:
    • B2R7L8

    Protein attributes for MTCH2 Gene

    303 amino acids
    Molecular mass:
    33331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTCH2 Gene

Post-translational modifications for MTCH2 Gene

  • Ubiquitination at Lys90, Lys100, isoforms=122, isoforms=293, and isoforms=300
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MTCH2 Gene

Domains & Families for MTCH2 Gene

Gene Families for MTCH2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for MTCH2 Gene

Suggested Antigen Peptide Sequences for MTCH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with MTCH2: view

Function for MTCH2 Gene

Molecular function for MTCH2 Gene

UniProtKB/Swiss-Prot Function:
The substrate transported is not yet known. Induces mitochondrial depolarization.

Phenotypes From GWAS Catalog for MTCH2 Gene

genes like me logo Genes that share phenotypes with MTCH2: view

Animal Models for MTCH2 Gene

MGI Knock Outs for MTCH2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MTCH2

Clone Products

  • Addgene plasmids for MTCH2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTCH2 Gene

Localization for MTCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTCH2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTCH2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 1
peroxisome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MTCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005739 mitochondrion IBA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IBA,IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MTCH2: view

Pathways & Interactions for MTCH2 Gene

SuperPathways for MTCH2 Gene

No Data Available

SIGNOR curated interactions for MTCH2 Gene


Gene Ontology (GO) - Biological Process for MTCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0043065 positive regulation of apoptotic process IBA --
GO:0070585 protein localization to mitochondrion IMP 23744079
genes like me logo Genes that share ontologies with MTCH2: view

No data available for Pathways by source for MTCH2 Gene

Drugs & Compounds for MTCH2 Gene

No Compound Related Data Available

Transcripts for MTCH2 Gene

Unigene Clusters for MTCH2 Gene

Mitochondrial carrier 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for MTCH2

Alternative Splicing Database (ASD) splice patterns (SP) for MTCH2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5: - -

Relevant External Links for MTCH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTCH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTCH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTCH2 Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTCH2 Gene

Protein tissue co-expression partners for MTCH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTCH2 Gene:


SOURCE GeneReport for Unigene cluster for MTCH2 Gene:


Evidence on tissue expression from TISSUES for MTCH2 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Blood(4.2)
  • Kidney(2.6)
genes like me logo Genes that share expression patterns with MTCH2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTCH2 Gene

Orthologs for MTCH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTCH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTCH2 33 34
  • 100 (n)
(Canis familiaris)
Mammalia MTCH2 33
  • 94.33 (n)
-- 34
  • 82 (a)
-- 34
  • 75 (a)
(Bos Taurus)
Mammalia MTCH2 34 33
  • 92.63 (n)
(Mus musculus)
Mammalia Mtch2 33 16 34
  • 91.09 (n)
(Rattus norvegicus)
Mammalia Mtch2 33
  • 90.87 (n)
(Ornithorhynchus anatinus)
Mammalia MTCH2 34
  • 77 (a)
(Monodelphis domestica)
Mammalia MTCH2 34
  • 65 (a)
(Gallus gallus)
Aves MTCH2 33 34
  • 70.41 (n)
(Anolis carolinensis)
Reptilia MTCH2 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtch2 33
  • 68.81 (n)
MGC76005 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64562 33
(Danio rerio)
Actinopterygii mtch2 33 34
  • 66.78 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.100 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006963 33
  • 47.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mtch 35 33 34
  • 46.64 (n)
CG10920 35 34
  • 34 (a)
(Caenorhabditis elegans)
Secernentea mtch-1 33 34
  • 43.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10453 34
  • 35 (a)
Species where no ortholog for MTCH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTCH2 Gene

Gene Tree for MTCH2 (if available)
Gene Tree for MTCH2 (if available)

Paralogs for MTCH2 Gene

Paralogs for MTCH2 Gene

(2) SIMAP similar genes for MTCH2 Gene using alignment to 3 proteins: Pseudogenes for MTCH2 Gene

genes like me logo Genes that share paralogs with MTCH2: view

Variants for MTCH2 Gene

Sequence variations from dbSNP and Humsavar for MTCH2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000040260 -- 47,638,235(-) A/G intron_variant
rs1000113549 -- 47,637,849(-) A/C intron_variant
rs1000149005 -- 47,626,712(-) C/T intron_variant
rs1000179993 -- 47,610,391(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000290449 -- 47,617,694(-) G/A 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MTCH2 Gene

Variant ID Type Subtype PubMed ID
esv1465053 CNV insertion 17803354
esv2744440 CNV deletion 23290073
esv3626206 CNV loss 21293372
esv995881 CNV insertion 20482838
esv998557 CNV insertion 20482838
nsv315 CNV insertion 18451855
nsv469858 CNV gain 16826518
nsv509405 CNV insertion 20534489
nsv69 CNV insertion 15895083
nsv825872 CNV gain 20364138
nsv832142 CNV loss 17160897

Variation tolerance for MTCH2 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.52; 88.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTCH2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTCH2 Gene

Disorders for MTCH2 Gene

Additional Disease Information for MTCH2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MTCH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTCH2 Gene

Publications for MTCH2 Gene

  1. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K … Nakamura Y (Journal of human genetics 2009) 3 22 44 58
  2. Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa? (PMID: 19746409) Brandys MK … Adan RAH (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  3. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. (PMID: 19812171) Li S … Loos RJ (The American journal of clinical nutrition 2010) 3 44 58
  4. Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. (PMID: 19910641) He M … Qi L (Arteriosclerosis, thrombosis, and vascular biology 2010) 3 44 58
  5. Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study. (PMID: 19910938) Haupt A … Staiger H (Obesity (Silver Spring, Md.) 2010) 3 44 58

Products for MTCH2 Gene

  • Addgene plasmids for MTCH2

Sources for MTCH2 Gene

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