Aliases for MTARC1 Gene
External Ids for MTARC1 Gene
Previous HGNC Symbols for MTARC1 Gene
GeneCards Summary for MTARC1 Gene
MTARC1 (Mitochondrial Amidoxime Reducing Component 1) is a Protein Coding gene. Diseases associated with MTARC1 include Good Syndrome and Microphthalmia, Syndromic 10. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. An important paralog of this gene is ENSG00000286231.
UniProtKB/Swiss-Prot Summary for MTARC1 Gene
Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:19053771). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045, PubMed:19053771).