Aliases for MTA3 Gene

Aliases for MTA3 Gene

  • Metastasis Associated 1 Family Member 3 2 3 5
  • Metastasis Associated Gene Family, Member 3 2 3
  • Metastasis-Associated Protein MTA3 3 4
  • KIAA1266 4

External Ids for MTA3 Gene

Previous GeneCards Identifiers for MTA3 Gene

  • GC02P042783
  • GC02P042963
  • GC02P042770
  • GC02P042696
  • GC02P042633
  • GC02P042577
  • GC02P042649
  • GC02P042722

Summaries for MTA3 Gene

GeneCards Summary for MTA3 Gene

MTA3 (Metastasis Associated 1 Family Member 3) is a Protein Coding gene. Diseases associated with MTA3 include Gastroesophageal Junction Adenocarcinoma and Vertebral, Cardiac, Renal, And Limb Defects Syndrome 1. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Development NOTCH1-mediated pathway for NF-KB activity modulation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is MTA1.

UniProtKB/Swiss-Prot Summary for MTA3 Gene

  • Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.

Gene Wiki entry for MTA3 Gene

Additional gene information for MTA3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MTA3 Gene

Genomics for MTA3 Gene

GeneHancer (GH) Regulatory Elements for MTA3 Gene

Promoters and enhancers for MTA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J042566 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 761.2 +73.9 73935 4.3 ZBTB6 RBPJ POU5F1 POLR2A SP1 ZNF148 NKRF ZFX ZNF384 ZNF687 MTA3 KCNG3 HAAO piR-50437-377 lnc-EML4-5
GH02J042492 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 -0.9 -907 4.9 CTCF SREBF1 TCF7L2 USF2 ZNF217 CREB1 ZNF362 CC2D1A L3MBTL2 MAX KCNG3 MTA3 HAAO COX7A2L RF00017-3172
GH02J042496 Enhancer 0.2 Ensembl 750.6 +1.9 1932 0.2 MTA3 RF00017-3173
GH02J043216 Promoter/Enhancer 3.1 VISTA UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13 +728.7 728716 13 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF ZBTB6 FOXA1 MLX RBPJ ZFP36L2 lnc-ZFP36L2-1 THADA RNU6-1048P ENSG00000234936 PLEKHH2 DYNC2LI1 VDAC1P13 PDSS1P2 MTA3
GH02J042808 Promoter/Enhancer 1.8 ENCODE CraniofacialAtlas dbSUPER 22 +315.9 315851 3.4 GTF3C2 SIN3A ZNF24 ZBTB40 CTCF LCORL ZBTB6 FOXA1 MLX SMARCE1 LOC105374567 TRI-TAT2-1 lnc-HAAO-1 lnc-MTA3-6 THADA DYNC2LI1 EML4 MTA3 PLEKHH2 OXER1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MTA3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MTA3 gene promoter:
  • AML1a
  • ER-alpha
  • Evi-1
  • FOXL1
  • ISGF-3
  • Pax-4a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • STAT5A

Genomic Locations for MTA3 Gene

Genomic Locations for MTA3 Gene
chr2:42,494,569-42,795,030
(GRCh38/hg38)
Size:
300,462 bases
Orientation:
Plus strand
chr2:42,721,709-42,984,087
(GRCh37/hg19)
Size:
262,379 bases
Orientation:
Plus strand

Genomic View for MTA3 Gene

Genes around MTA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTA3 Gene

Proteins for MTA3 Gene

  • Protein details for MTA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTC8-MTA3_HUMAN
    Recommended name:
    Metastasis-associated protein MTA3
    Protein Accession:
    Q9BTC8
    Secondary Accessions:
    • Q9NSP2
    • Q9ULF4

    Protein attributes for MTA3 Gene

    Size:
    594 amino acids
    Molecular mass:
    67504 Da
    Quaternary structure:
    • Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with BCL6. Interacts with NACC2.
    SequenceCaution:
    • Sequence=BAA86580.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MTA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTA3 Gene

Post-translational modifications for MTA3 Gene

  • Ubiquitination at Lys61
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MTA3 Gene

Domains & Families for MTA3 Gene

Gene Families for MTA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for MTA3 Gene

GenScript: Design optimal peptide antigens:
  • Metastasis-associated protein MTA3 (MTA3_HUMAN)
genes like me logo Genes that share domains with MTA3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MTA3 Gene

Function for MTA3 Gene

Molecular function for MTA3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
UniProtKB/Swiss-Prot Induction:
By estrogen.

Phenotypes From GWAS Catalog for MTA3 Gene

Gene Ontology (GO) - Molecular Function for MTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001103 RNA polymerase II repressing transcription factor binding IBA 21873635
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003713 transcription coactivator activity IBA 21873635
genes like me logo Genes that share ontologies with MTA3: view
genes like me logo Genes that share phenotypes with MTA3: view

Animal Models for MTA3 Gene

MGI Knock Outs for MTA3:
  • Mta3 Mta3<tm3a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for MTA3 Gene

miRTarBase miRNAs that target MTA3

Clone Products

  • Addgene plasmids for MTA3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTA3 Gene

Localization for MTA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTA3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTA3 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IBA --
GO:0005654 nucleoplasm TAS,IBA --
GO:0005737 cytoplasm IEA --
GO:0016581 NuRD complex IDA 22926524
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with MTA3: view

Pathways & Interactions for MTA3 Gene

genes like me logo Genes that share pathways with MTA3: view

SIGNOR curated interactions for MTA3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle IEA --
GO:0016575 histone deacetylation IBA 21873635
genes like me logo Genes that share ontologies with MTA3: view

Drugs & Compounds for MTA3 Gene

(1) Drugs for MTA3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MTA3: view

Transcripts for MTA3 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for MTA3

Alternative Splicing Database (ASD) splice patterns (SP) for MTA3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d ·
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6:
SP7:
SP8:
SP9:
SP10: -

ExUns: 20e ^ 21 ^ 22a · 22b ^ 23
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for MTA3 Gene

GeneLoc Exon Structure for
MTA3
ECgene alternative splicing isoforms for
MTA3

Expression for MTA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTA3 Gene

Protein differential expression in normal tissues from HIPED for MTA3 Gene

This gene is overexpressed in Placenta (15.8), Lung (15.0), Peripheral blood mononuclear cells (8.7), and Testis (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MTA3 Gene



Protein tissue co-expression partners for MTA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTA3 Gene:

MTA3

SOURCE GeneReport for Unigene cluster for MTA3 Gene:

Hs.435413

mRNA Expression by UniProt/SwissProt for MTA3 Gene:

Q9BTC8-MTA3_HUMAN
Tissue specificity: Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.

Evidence on tissue expression from TISSUES for MTA3 Gene

  • Nervous system(4.8)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with MTA3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTA3 Gene

Orthologs for MTA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTA3 33 32
  • 99.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MTA3 33 32
  • 93.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MTA3 33 32
  • 93.16 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTA3 33
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mta3 17 33 32
  • 86.36 (n)
rat
(Rattus norvegicus)
Mammalia Mta3 32
  • 84.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MTA3 33
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTA3 33 32
  • 83.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTA3 33
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mta3 33 32
  • 70.29 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lin-40 32
  • 52.58 (n)
Species where no ortholog for MTA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MTA3 Gene

ENSEMBL:
Gene Tree for MTA3 (if available)
TreeFam:
Gene Tree for MTA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MTA3: view image

Paralogs for MTA3 Gene

Paralogs for MTA3 Gene

(20) SIMAP similar genes for MTA3 Gene using alignment to 7 proteins:

  • MTA3_HUMAN
  • C9JR73_HUMAN
  • D6W5A2_HUMAN
  • E7EQY4_HUMAN
  • E7EV10_HUMAN
  • E9PCS8_HUMAN
  • E9PF88_HUMAN

Pseudogenes.org Pseudogenes for MTA3 Gene

genes like me logo Genes that share paralogs with MTA3: view

Variants for MTA3 Gene

Sequence variations from dbSNP and Humsavar for MTA3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1135401743 pathogenic, Congenital NAD deficiency disorder, VERTEBRAL, CARDIAC, RENAL, AND LIMB DEFECTS SYNDROME 1 42,769,785(+) C/A/T genic_downstream_transcript_variant, intron_variant
rs1558553140 likely-pathogenic, Short stature 42,659,795(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs527656756 pathogenic, Congenital NAD deficiency disorder, VERTEBRAL, CARDIAC, RENAL, AND LIMB DEFECTS SYNDROME 1 42,770,144(+) A/AA genic_downstream_transcript_variant, intron_variant
rs1000006332 -- 42,772,903(+) G/GG genic_downstream_transcript_variant, intron_variant
rs1000012233 -- 42,791,460(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MTA3 Gene

Variant ID Type Subtype PubMed ID
esv2671402 CNV deletion 23128226
esv2678416 CNV deletion 23128226
esv2719982 CNV deletion 23290073
esv3334685 CNV insertion 20981092
esv3555633 CNV deletion 23714750
esv3583763 CNV loss 25503493
esv3590505 CNV loss 21293372
esv3590507 CNV loss 21293372
esv3590508 CNV loss 21293372
nsv1110739 CNV insertion 24896259
nsv1127723 CNV deletion 24896259
nsv1129634 CNV tandem duplication 24896259
nsv1136297 CNV deletion 24896259
nsv1138770 CNV deletion 24896259
nsv1138771 CNV deletion 24896259
nsv1142272 CNV tandem duplication 24896259
nsv457152 CNV loss 19166990
nsv478760 CNV novel sequence insertion 20440878
nsv519877 CNV loss 19592680
nsv524679 CNV loss 19592680
nsv581644 CNV loss 21841781
nsv817795 CNV gain 17921354
nsv961770 CNV duplication 23825009

Variation tolerance for MTA3 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTA3 Gene

Human Gene Mutation Database (HGMD)
MTA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTA3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTA3 Gene

Disorders for MTA3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MTA3 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
gastroesophageal junction adenocarcinoma
  • adenocarcinoma of cardioesophageal junction
vertebral, cardiac, renal, and limb defects syndrome 1
  • vcrl1
hypertrophic pyloric stenosis
  • congenital hypertrophic pyloric stenosis
pyloric stenosis
- elite association - COSMIC cancer census association via MalaCards
Search MTA3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MTA3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MTA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTA3 Gene

Publications for MTA3 Gene

  1. Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility. (PMID: 16502042) Yu JC … Shen CY (Journal of biomedical science 2006) 3 23 43 56
  2. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. (PMID: 12705869) Fujita N … Wade PA (Cell 2003) 2 3 4 56
  3. Emerging roles of MTA family members in human cancers. (PMID: 14613024) Kumar R … Bagheri-Yarmand R (Seminars in oncology 2003) 2 3 23 56
  4. RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. (PMID: 22926524) Xuan C … Shang Y (Oncogene 2013) 3 4 56
  5. The metastasis-associated genes MTA1 and MTA3 are abundantly expressed in human placenta and chorionic carcinoma cells. (PMID: 19363681) Brüning A … Mylonas I (Histochemistry and cell biology 2009) 3 23 56

Products for MTA3 Gene

Sources for MTA3 Gene