MTA2 Gene (Protein Coding)

Metastasis Associated 1 Family Member 2

GC11M062594
GIFtS:
40
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly ... See more...

Aliases for MTA2 Gene

Aliases for MTA2 Gene

  • Metastasis Associated 1 Family Member 2 2 3 5
  • Metastasis Associated Gene Family, Member 2 2 3
  • P53 Target Protein In Deacetylase Complex 3 4
  • Metastasis-Associated Protein MTA2 3 4
  • Metastasis-Associated 1-Like 1 3 4
  • MTA1-L1 Protein 3 4
  • MTA1L1 3 4
  • PID 3 4
  • Metastasis -Associated Gene 1-Like 1 3
  • Metastasis-Associated Protein 2 3

External Ids for MTA2 Gene

Previous HGNC Symbols for MTA2 Gene

  • MTA1L1

Previous GeneCards Identifiers for MTA2 Gene

  • GC11M062136
  • GC11M062119
  • GC11M062360
  • GC11M058689

Summaries for MTA2 Gene

Entrez Gene Summary for MTA2 Gene

  • This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

GeneCards Summary for MTA2 Gene

MTA2 (Metastasis Associated 1 Family Member 2) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is MTA1.

UniProtKB/Swiss-Prot Summary for MTA2 Gene

  • May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Gene Wiki entry for MTA2 Gene

Additional gene information for MTA2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MTA2 Gene

Genomics for MTA2 Gene

GeneHancer (GH) Regulatory Elements for MTA2 Gene

Promoters and enhancers for MTA2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MTA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MTA2 gene promoter:
  • CREB
  • CUTL1
  • deltaCREB
  • p53
  • Sp1
  • YY1

Genomic Locations for MTA2 Gene

Genomic Locations for MTA2 Gene
chr11:62,593,203-62,601,865
(GRCh38/hg38)
Size:
8,663 bases
Orientation:
Minus strand
chr11:62,360,675-62,369,312
(GRCh37/hg19)
Size:
8,638 bases
Orientation:
Minus strand

Genomic View for MTA2 Gene

Genes around MTA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTA2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MTA2 Gene

Proteins for MTA2 Gene

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  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94776-MTA2_HUMAN
    Recommended name:
    Metastasis-associated protein MTA2
    Protein Accession:
    O94776
    Secondary Accessions:
    • Q68DB1
    • Q9UQB5

    Protein attributes for MTA2 Gene

    Size:
    668 amino acids
    Molecular mass:
    75023 Da
    Quaternary structure:
    • Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC7, p53/TP53, MINT and MBD3 (By similarity). Interacts with PIMREG. Interacts with NACC2.
    SequenceCaution:
    • Sequence=AAH23656.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTA2 Gene

Protein Expression for MTA2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MTA2 Gene

  • Ubiquitination at Lys152, Lys508, Lys522, and Lys611
  • Modification sites at PhosphoSitePlus

Other Protein References for MTA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTA2 Gene

Domains & Families for MTA2 Gene

Gene Families for MTA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MTA2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTA2 Gene

GenScript: Design optimal peptide antigens:
  • p53 target protein in deacetylase complex (MTA2_HUMAN)
genes like me logo Genes that share domains with MTA2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MTA2 Gene

Function for MTA2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MTA2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Phenotypes From GWAS Catalog for MTA2 Gene

Gene Ontology (GO) - Molecular Function for MTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 contributes_to transcription regulatory region sequence-specific DNA binding IDA 16217013
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001085 RNA polymerase II transcription factor binding IPI 15920471
GO:0001103 RNA polymerase II repressing transcription factor binding IPI,IBA 22926524
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MTA2: view
genes like me logo Genes that share phenotypes with MTA2: view

Animal Models for MTA2 Gene

MGI Knock Outs for MTA2:
  • Mta2 Mta2<tm1.1Yzha>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTA2 Gene

Localization for MTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTA2 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTA2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex TAS 10444591
GO:0000790 nuclear chromatin HDA 16217013
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS,IBA --
GO:0005667 transcription factor complex IDA 15920471
genes like me logo Genes that share ontologies with MTA2: view

Pathways & Interactions for MTA2 Gene

genes like me logo Genes that share pathways with MTA2: view

SIGNOR curated interactions for MTA2 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006306 DNA methylation IEA --
GO:0006333 chromatin assembly or disassembly TAS 10444591
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010762 regulation of fibroblast migration IEA --
genes like me logo Genes that share ontologies with MTA2: view

Drugs & Compounds for MTA2 Gene

Products:

  1. Drug

(1) Drugs for MTA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MTA2: view

Transcripts for MTA2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MTA2 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1:
SP2:
SP3: - - -
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9:

ExUns: 20a · 20b ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MTA2 Gene

GeneLoc Exon Structure for
MTA2
ECgene alternative splicing isoforms for
MTA2

Expression for MTA2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTA2 Gene

mRNA expression in normal human tissues for MTA2 Gene
mRNA expression by GTEx for MTA2 GenemRNA expression by BioGPS for MTA2 Gene

Protein differential expression in normal tissues from HIPED for MTA2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), Breast (8.6), and Lymph node (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MTA2 Gene



Protein tissue co-expression partners for MTA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MTA2 Gene:

MTA2

SOURCE GeneReport for Unigene cluster for MTA2 Gene:

Hs.173043

mRNA Expression by UniProt/SwissProt for MTA2 Gene:

O94776-MTA2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for MTA2 Gene

  • Nervous system(4.3)
  • Eye(4.2)
  • Liver(4.2)
  • Lymph node(2.6)
  • Intestine(2)
genes like me logo Genes that share expression patterns with MTA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTA2 Gene

Orthologs for MTA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MTA2 33
  • 100 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia MTA2 33
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia MTA2 33 32
  • 93.11 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia MTA2 33 32
  • 93.04 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mta2 17 33 32
  • 91.17 (n)
rat
(Rattus norvegicus)
 Mammalia Mta2 32
  • 90.52 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia MTA2 33
  • 89 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MTA2 33
  • 81 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mta2 32
  • 75.45 (n)
Str.6927 32
African clawed frog
(Xenopus laevis)
 Amphibia Xl.545 32
zebrafish
(Danio rerio)
 Actinopterygii mta2 33 32
  • 71.96 (n)
 OneToOne
wufi29g02 32
fruit fly
(Drosophila melanogaster)
 Insecta MTA1-like 33
  • 38 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea lin-40 33
  • 23 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 54 (a)
 OneToOne
Species where no ortholog for MTA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTA2 Gene

ENSEMBL:
Gene Tree for MTA2 (if available)
TreeFam:
Gene Tree for MTA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MTA2: view image

Paralogs for MTA2 Gene

Paralogs for MTA2 Gene

(4) SIMAP similar genes for MTA2 Gene using alignment to 1 proteins:

  • MTA2_HUMAN
genes like me logo Genes that share paralogs with MTA2: view

Variants for MTA2 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MTA2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000199823 -- 62,594,840(-) A/C intron_variant
rs1000446112 -- 62,598,835(-) A/G intron_variant
rs1000692205 -- 62,601,142(-) C/T 5_prime_UTR_variant, intron_variant
rs1001183217 -- 62,598,187(-) G/A intron_variant
rs1001237165 -- 62,598,444(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MTA2 Gene

Variant ID Type Subtype PubMed ID
esv3579735 CNV loss 25503493
esv3584599 CNV gain 24956385
nsv514630 CNV gain 21397061
nsv555174 CNV gain 21841781
nsv825939 CNV gain 20364138
nsv832180 CNV loss 17160897
nsv832182 CNV gain+loss 17160897

Variation tolerance for MTA2 Gene

Residual Variation Intolerance Score: 3.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTA2 Gene

Disorders for MTA2 Gene

Additional Disease Information for MTA2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MTA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTA2 Gene

Publications for MTA2 Gene

  1. Molecular cloning, mapping, and characterization of a novel human gene, MTA1-L1, showing homology to a metastasis-associated gene, MTA1. (PMID: 9929979) Futamura M … Tokino T (Journal of human genetics 1999) 2 3 4 23 56
  2. RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. (PMID: 22926524) Xuan C … Shang Y (Oncogene 2013) 3 4 56
  3. Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation. (PMID: 19702911) Lee H … Kim KW (Journal of gastroenterology and hepatology 2009) 3 23 56
  4. Members of the NuRD chromatin remodeling complex interact with AUF1 in developing cortical neurons. (PMID: 18413351) Lee C … Agoston DV (Cerebral cortex (New York, N.Y. : 1991) 2008) 3 23 56
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 56

ExternalLinks

View latest publications for MTA2 gene in Mastermind

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