Aliases for MTA2 Gene
External Ids for MTA2 Gene
Previous HGNC Symbols for MTA2 Gene
Previous GeneCards Identifiers for MTA2 Gene
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]
GeneCards Summary for MTA2 Gene
MTA2 (Metastasis Associated 1 Family Member 2) is a Protein Coding gene. Diseases associated with MTA2 include Prostate Transitional Cell Carcinoma. Among its related pathways are RNA Polymerase I Promoter Escape and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is MTA1.
UniProtKB/Swiss-Prot Summary for MTA2 Gene
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.