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This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]
MTA2 (Metastasis Associated 1 Family Member 2) is a Protein Coding gene. Diseases associated with MTA2 include Prostate Transitional Cell Carcinoma. Among its related pathways are RNA Polymerase I Promoter Escape and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is MTA1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001085 | RNA polymerase II transcription factor binding | IPI | 15920471 |
GO:0001103 | RNA polymerase II repressing transcription factor binding | IBA,IPI | 22926524 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003682 | chromatin binding | IEA | -- |
GO:0003712 | transcription coregulator activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000118 | histone deacetylase complex | TAS | 10444591 |
GO:0000785 | chromatin | HDA | 16217013 |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005667 | transcription factor complex | IDA | 15920471 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0006306 | DNA methylation | IEA | -- |
GO:0006333 | chromatin assembly or disassembly | TAS | 10444591 |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0010762 | regulation of fibroblast migration | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
ExUns: | 20a | · | 20b | ^ | 21 |
---|---|---|---|---|---|
SP1: | |||||
SP2: | |||||
SP3: | |||||
SP4: | |||||
SP5: | |||||
SP6: | |||||
SP7: | |||||
SP8: | |||||
SP9: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MTA2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MTA2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MTA2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MTA2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mta2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mta2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | MTA2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MTA2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mta2 30 |
|
||
Str.6927 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.545 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mta2 30 31 |
|
OneToOne | |
wufi29g02 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | MTA1-like 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | lin-40 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
prostate transitional cell carcinoma |
|
|