Aliases for MT4 Gene

Aliases for MT4 Gene

  • Metallothionein 4 2 3 5
  • Metallothionein-IV 3 4
  • Metallothionein-4 3 4
  • MT-IV 3 4
  • MT-4 3 4
  • Metallothionein IV 2
  • MTIV 3

External Ids for MT4 Gene

Previous GeneCards Identifiers for MT4 Gene

  • GC16P046982
  • GC16P056650
  • GC16P056333
  • GC16P056374
  • GC16P055156
  • GC16P056598
  • GC16P042469

Summaries for MT4 Gene

GeneCards Summary for MT4 Gene

MT4 (Metallothionein 4) is a Protein Coding gene. Diseases associated with MT4 include Pthirus Pubis Infestation and Lice Infestation. Among its related pathways are Response to metal ions and Metabolism. An important paralog of this gene is MT2A.

UniProtKB/Swiss-Prot Summary for MT4 Gene

  • Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.

Additional gene information for MT4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MT4 Gene

Genomics for MT4 Gene

GeneHancer (GH) Regulatory Elements for MT4 Gene

Promoters and enhancers for MT4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J056565 Promoter 0.5 EPDnew 500.7 +0.0 9 0.1 SCRT1 SCRT2 MT4 RF00066-074
GH16J056604 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.5 +45.1 45107 10.8 FOXK2 SIN3A NRF1 TCF12 POLR2G NCOR1 JUND FOS ZNF10 REST MT2A ENSG00000260823 NONHSAG019534.2 RSPRY1 BBS2 MT1A MT1F NUDT21 MT1G MT1H
GH16J056551 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 14 -12.8 -12848 1.2 NCOR1 KDM6A TCF7 ZBTB7A TEAD1 ZBTB26 ZKSCAN8 ZSCAN9 NR2F2 CEBPB MT3 BBS2 MT4 MT1G MT1H MT1F MT1X GNAO1 lnc-BBS2-2
GH16J056518 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 7.6 -45.4 -45404 3.1 ZNF217 EP300 SIN3A NRF1 POLR2G PHF8 ZFX ZIC2 POLR2A CLOCK BBS2 OGFOD1 MT3 MT1G MT1H MT1A NUDT21 MT4 lnc-NUDT21-4
GH16J056546 Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 12.7 -17.3 -17329 2 POLR2A HDAC2 GABPA FOS TBP ZSCAN16 GTF3C2 ZEB2 ATF1 NR3C1 lnc-BBS2-2 BBS2 MT3 MT4 MT1A MT1G MT1H GNAO1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MT4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MT4

Top Transcription factor binding sites by QIAGEN in the MT4 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • IRF-2
  • NF-1
  • SRY
  • TBP

Genomic Locations for MT4 Gene

Genomic Locations for MT4 Gene
chr16:56,565,049-56,568,957
(GRCh38/hg38)
Size:
3,909 bases
Orientation:
Plus strand
chr16:56,598,961-56,602,869
(GRCh37/hg19)
Size:
3,909 bases
Orientation:
Plus strand

Genomic View for MT4 Gene

Genes around MT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT4 Gene

Proteins for MT4 Gene

  • Protein details for MT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47944-MT4_HUMAN
    Recommended name:
    Metallothionein-4
    Protein Accession:
    P47944
    Secondary Accessions:
    • Q14DA1

    Protein attributes for MT4 Gene

    Size:
    62 amino acids
    Molecular mass:
    6509 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MT4 Gene

Post-translational modifications for MT4 Gene

No Post-translational modifications

Other Protein References for MT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT4 Gene

Domains & Families for MT4 Gene

Gene Families for MT4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MT4 Gene

Suggested Antigen Peptide Sequences for MT4 Gene

GenScript: Design optimal peptide antigens:
  • Metallothionein-IV (MT4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P47944

UniProtKB/Swiss-Prot:

MT4_HUMAN :
  • Belongs to the metallothionein superfamily. Type 1 family.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT4: view

Function for MT4 Gene

Molecular function for MT4 Gene

UniProtKB/Swiss-Prot Function:
Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.

Phenotypes From GWAS Catalog for MT4 Gene

Gene Ontology (GO) - Molecular Function for MT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IBA 21873635
genes like me logo Genes that share ontologies with MT4: view
genes like me logo Genes that share phenotypes with MT4: view

Animal Model Products

miRNA for MT4 Gene

miRTarBase miRNAs that target MT4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MT4 Gene

Localization for MT4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT4 gene
Compartment Confidence
nucleus 4
extracellular 3
mitochondrion 3
cytosol 3
plasma membrane 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
endosome 1

Gene Ontology (GO) - Cellular Components for MT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with MT4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MT4 Gene

Pathways & Interactions for MT4 Gene

genes like me logo Genes that share pathways with MT4: view

Pathways by source for MT4 Gene

2 BioSystems pathways for MT4 Gene

Gene Ontology (GO) - Biological Process for MT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006875 cellular metal ion homeostasis IEA --
GO:0006882 cellular zinc ion homeostasis IBA 21873635
GO:0008150 biological_process ND --
GO:0010273 detoxification of copper ion IBA 21873635
GO:0071276 cellular response to cadmium ion IBA 21873635
genes like me logo Genes that share ontologies with MT4: view

No data available for SIGNOR curated interactions for MT4 Gene

Drugs & Compounds for MT4 Gene

(3) Drugs for MT4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Carrier, binder 236
Silver Approved, Investigational Pharma Target, binder 0
genes like me logo Genes that share compounds with MT4: view

Transcripts for MT4 Gene

mRNA/cDNA for MT4 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT4 Gene

No ASD Table

Relevant External Links for MT4 Gene

GeneLoc Exon Structure for
MT4

Expression for MT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MT4 Gene

mRNA differential expression in normal tissues according to GTEx for MT4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x28.1) and Skin - Sun Exposed (Lower leg) (x19.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MT4

SOURCE GeneReport for Unigene cluster for MT4 Gene:

Hs.567624
genes like me logo Genes that share expression patterns with MT4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MT4 Gene

Orthologs for MT4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT4 31 30
  • 98.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mt4 31
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MT4 31
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MT4 31
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MT4 31
  • 83 (a)
OneToOne
Species where no ortholog for MT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT4 Gene

ENSEMBL:
Gene Tree for MT4 (if available)
TreeFam:
Gene Tree for MT4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MT4: view image

Paralogs for MT4 Gene

Paralogs for MT4 Gene

(11) SIMAP similar genes for MT4 Gene using alignment to 1 proteins:

  • MT4_HUMAN
genes like me logo Genes that share paralogs with MT4: view

Variants for MT4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MT4 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs11643815 - p.Gly48Asp
rs666636 - p.Tyr30Cys
rs666647 - p.Trp31Arg

Additional dbSNP identifiers (rs#s) for MT4 Gene

Structural Variations from Database of Genomic Variants (DGV) for MT4 Gene

Variant ID Type Subtype PubMed ID
esv2714513 CNV deletion 23290073
esv2714514 CNV deletion 23290073
esv3582247 CNV loss 25503493
nsv1131260 CNV deletion 24896259

Variation tolerance for MT4 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT4 Gene

Disorders for MT4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MT4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pthirus pubis infestation
  • crabs
lice infestation
  • infestation by pediculus
parasitic ectoparasitic infectious disease
  • ectoparasitism
metal metabolism disorder
  • inborn metal metabolism disorder
cone-rod dystrophy 2
  • cord2
- elite association - COSMIC cancer census association via MalaCards
Search MT4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MT4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MT4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MT4 Gene

Publications for MT4 Gene

  1. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. (PMID: 8003488) Quaife CJ … Palmiter RD (Biochemistry 1994) 2 3 4 23 54
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41 54
  3. The association of metallothionein-4 gene polymorphism and renal function in long-term lead-exposed workers. (PMID: 19921116) Chen HI … Chuang HY (Biological trace element research 2010) 3 41 54
  4. Genetic background of lead and mercury metabolism in a group of medical students in Austria. (PMID: 19515364) Gundacker C … Gencik M (Environmental research 2009) 3 41 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for MT4 Gene

  • Signalway ELISA kits for MT4
  • Signalway Proteins for MT4

Sources for MT4 Gene