Aliases for MT3 Gene
External Ids for MT3 Gene
Previous GeneCards Identifiers for MT3 Gene
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease. [provided by RefSeq, Sep 2017]
GeneCards Summary for MT3 Gene
MT3 (Metallothionein 3) is a Protein Coding gene. Diseases associated with MT3 include Alzheimer Disease and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Response to metal ions and Metabolism. Gene Ontology (GO) annotations related to this gene include drug binding and antioxidant activity. An important paralog of this gene is MT1F.
UniProtKB/Swiss-Prot Summary for MT3 Gene
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.