This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus ... See more...

Aliases for MT3 Gene

Aliases for MT3 Gene

  • Metallothionein 3 2 3 5
  • Metallothionein 3 (Growth Inhibitory Factor (Neurotrophic)) 2 3
  • Growth Inhibitory Factor 3 4
  • Metallothionein-III 3 4
  • Metallothionein-3 3 4
  • GIFB 3 4
  • GIF 3 4
  • MT-III 4
  • ZnMT3 3
  • GRIF 3
  • MT-3 4

External Ids for MT3 Gene

Previous GeneCards Identifiers for MT3 Gene

  • GC16P047006
  • GC16P056674
  • GC16P056357
  • GC16P056398
  • GC16P055180
  • GC16P056623
  • GC16P042492

Summaries for MT3 Gene

Entrez Gene Summary for MT3 Gene

  • This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease. [provided by RefSeq, Sep 2017]

GeneCards Summary for MT3 Gene

MT3 (Metallothionein 3) is a Protein Coding gene. Diseases associated with MT3 include Alzheimer Disease and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Response to metal ions and Metabolism. Gene Ontology (GO) annotations related to this gene include drug binding and antioxidant activity. An important paralog of this gene is MT1F.

UniProtKB/Swiss-Prot Summary for MT3 Gene

  • Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.

Gene Wiki entry for MT3 Gene

Additional gene information for MT3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MT3 Gene

Genomics for MT3 Gene

GeneHancer (GH) Regulatory Elements for MT3 Gene

Promoters and enhancers for MT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J056589 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 500.7 +0.3 327 0.8 HDAC2 EZH2 SMC3 MXI1 KLF9 CTCF TBP CTBP2 SUZ12 BACH1 HSALNG0111695 MT3 MT1E
GH16J056604 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 +21.1 21082 10.8 FOXK2 SIN3A NRF1 TCF12 POLR2G NCOR1 JUND FOS ZNF10 REST MT2A ENSG00000260823 NONHSAG019534.2 RSPRY1 BBS2 MT1A MT1F NUDT21 MT1G MT1H
GH16J056518 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 -69.4 -69429 3.1 ZNF217 EP300 SIN3A NRF1 POLR2G PHF8 ZFX ZIC2 POLR2A CLOCK BBS2 OGFOD1 MT3 MT1G MT1H MT1A NUDT21 MT4 lnc-NUDT21-4
GH16J056551 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 17.8 -36.9 -36873 1.2 NCOR1 KDM6A TCF7 ZBTB7A TEAD1 ZBTB26 ZKSCAN8 ZSCAN9 NR2F2 CEBPB MT3 BBS2 MT4 MT1G MT1H MT1F MT1X GNAO1 lnc-BBS2-2
GH16J056624 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 12.4 +37.1 37099 3.1 POLR2G ZNF639 REST POLR2A MEF2C SKI TEAD1 BCL11A TCF12 SRSF1 MT1E MT3 MT1G MT1H MT1B MT1F MT1X MT1A BBS2 NUP93
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MT3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MT3

Top Transcription factor binding sites by QIAGEN in the MT3 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • p53
  • POU2F1
  • POU2F1a
  • STAT3

Genomic Locations for MT3 Gene

Genomic Locations for MT3 Gene
chr16:56,589,074-56,591,088
(GRCh38/hg38)
Size:
2,015 bases
Orientation:
Plus strand
chr16:56,622,986-56,625,000
(GRCh37/hg19)
Size:
2,015 bases
Orientation:
Plus strand

Genomic View for MT3 Gene

Genes around MT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT3 Gene

Proteins for MT3 Gene

  • Protein details for MT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25713-MT3_HUMAN
    Recommended name:
    Metallothionein-3
    Protein Accession:
    P25713
    Secondary Accessions:
    • Q2V574

    Protein attributes for MT3 Gene

    Size:
    68 amino acids
    Molecular mass:
    6927 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MT3 Gene

neXtProt entry for MT3 Gene

Post-translational modifications for MT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT3 Gene

No data available for DME Specific Peptides for MT3 Gene

Domains & Families for MT3 Gene

Gene Families for MT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MT3 Gene

GenScript: Design optimal peptide antigens:
  • Metallothionein-III (MT3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25713

UniProtKB/Swiss-Prot:

MT3_HUMAN :
  • Belongs to the metallothionein superfamily. Type 1 family.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT3: view

Function for MT3 Gene

Molecular function for MT3 Gene

UniProtKB/Swiss-Prot Function:
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.
GENATLAS Biochemistry:
metallothionein 3,expressed in brain,growth inhibitory factor,neurotrophic

Phenotypes From GWAS Catalog for MT3 Gene

Gene Ontology (GO) - Molecular Function for MT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding TAS 8751715
GO:0005515 protein binding IPI 20646067
GO:0008144 drug binding IDA 19536566
GO:0008270 zinc ion binding IEA,IDA 17712581
GO:0016209 antioxidant activity NAS 12383939
genes like me logo Genes that share ontologies with MT3: view
genes like me logo Genes that share phenotypes with MT3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MT3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT3 Gene

Localization for MT3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT3 gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 4
plasma membrane 3
cytoskeleton 3
mitochondrion 3
endoplasmic reticulum 3
peroxisome 2
lysosome 2
golgi apparatus 2
endosome 1

Gene Ontology (GO) - Cellular Components for MT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005623 cell IEA --
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA,IDA 10355541
GO:0005741 mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with MT3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MT3 Gene

Pathways & Interactions for MT3 Gene

genes like me logo Genes that share pathways with MT3: view

Pathways by source for MT3 Gene

2 BioSystems pathways for MT3 Gene

Gene Ontology (GO) - Biological Process for MT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 12763630
GO:0001934 positive regulation of protein phosphorylation IDA 18295594
GO:0006112 energy reserve metabolic process ISS --
GO:0006707 cholesterol catabolic process ISS --
GO:0006829 zinc ion transport ISS --
genes like me logo Genes that share ontologies with MT3: view

No data available for SIGNOR curated interactions for MT3 Gene

Drugs & Compounds for MT3 Gene

(18) Drugs for MT3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Carrier, binder 236
Zinc Approved, Investigational Pharma Target 2822
Silver Approved, Investigational Pharma Target, binder 0
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target 0

(8) Additional Compounds for MT3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MT3: view

Transcripts for MT3 Gene

mRNA/cDNA for MT3 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MT3

Alternative Splicing Database (ASD) splice patterns (SP) for MT3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -
SP3:

Relevant External Links for MT3 Gene

GeneLoc Exon Structure for
MT3

Expression for MT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MT3 Gene

This gene is overexpressed in Brain - Amygdala (x6.2), Brain - Putamen (basal ganglia) (x5.6), Brain - Caudate (basal ganglia) (x5.4), Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Hippocampus (x5.0), and Brain - Substantia nigra (x4.8).

Protein differential expression in normal tissues from HIPED for MT3 Gene

This gene is overexpressed in Brain (36.6), Fetal Brain (19.0), and Frontal cortex (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MT3 Gene



Protein tissue co-expression partners for MT3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MT3

SOURCE GeneReport for Unigene cluster for MT3 Gene:

Hs.73133

mRNA Expression by UniProt/SwissProt for MT3 Gene:

P25713-MT3_HUMAN
Tissue specificity: Abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the Alzheimer disease (AD) brain.

Evidence on tissue expression from TISSUES for MT3 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with MT3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MT3 Gene

Orthologs for MT3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT3 31 30
  • 99.02 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MT3 31
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mt3 31
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MT3 31
  • 87 (a)
OneToOne
Species where no ortholog for MT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT3 Gene

ENSEMBL:
Gene Tree for MT3 (if available)
TreeFam:
Gene Tree for MT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MT3: view image

Paralogs for MT3 Gene

Paralogs for MT3 Gene

(6) SIMAP similar genes for MT3 Gene using alignment to 4 proteins:

  • MT3_HUMAN
  • H3BPK2_HUMAN
  • H3BQX6_HUMAN
  • H3BTG5_HUMAN
genes like me logo Genes that share paralogs with MT3: view

Variants for MT3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MT3 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
710576 Benign: not provided 56,590,942(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for MT3 Gene

Variation tolerance for MT3 Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 9.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MT3 Gene

Disorders for MT3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MT3 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MT3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MT3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MT3 Gene

Publications for MT3 Gene

  1. MT-III, a brain-specific member of the metallothionein gene family. (PMID: 1631128) Palmiter RD … Durnam DM (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 23 54
  2. Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population. (PMID: 16546755) Hayashi Y … Hozumi I (Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2006) 3 23 41 54
  3. Screening the metallothionein III gene in sporadic amyotrophic lateral sclerosis. (PMID: 16036436) Morahan JM … Pamphlett R (Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2005) 3 23 41 54
  4. Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes. (PMID: 7677777) Amoureux MC … Pauwels PJ (Biochemical and biophysical research communications 1995) 3 4 23 54
  5. Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease. (PMID: 1464312) Tsuji S … Miyatake T (The EMBO journal 1992) 3 4 23 54

Products for MT3 Gene

Sources for MT3 Gene