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Aliases for MT2A Gene

Subcategory (RNA class) for MT2A Gene

lncRNA

Aliases for MT2A Gene

  • Metallothionein 2A 2 3 5
  • Metallothionein-II 3 4
  • MT-II 3 4
  • MT-2 3 4
  • MT2 3 4
  • Metallothionein-2A 4
  • Metallothionein-2 3
  • CES1 4

External Ids for MT2A Gene

Previous HGNC Symbols for MT2A Gene

  • MT2

Previous GeneCards Identifiers for MT2A Gene

  • GC16P047025
  • GC16P056693
  • GC16P056376
  • GC16P056417
  • GC16P055199
  • GC16P056642
  • GC16P042512
  • GC16P056610
  • GC16P056611
  • GC16P056612
  • GC16P056613
  • GC16P056614
  • GC16P056615
  • GC16P056618
  • GC16P056619

Summaries for MT2A Gene

Entrez Gene Summary for MT2A Gene

  • This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer. [provided by RefSeq, Sep 2017]

GeneCards Summary for MT2A Gene

MT2A (Metallothionein 2A) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with MT2A include Xeroderma Pigmentosum, Complementation Group B and Inverted Papilloma. Among its related pathways are Metallothioneins bind metals and Metabolism. Gene Ontology (GO) annotations related to this gene include drug binding. An important paralog of this gene is MT1G.

UniProtKB/Swiss-Prot for MT2A Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Wiki entry for MT2A Gene

fRNAdb sequence ontologies for MT2A Gene

  • ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for MT2A

Additional gene information for MT2A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for MT2A Gene

Genomics for MT2A Gene

GeneHancer (GH) Regulatory Elements for MT2A Gene

Promoters and enhancers for MT2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J056604 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 653.7 +2.0 1957 10.8 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 MT2A ENSG00000260823 GC16P056608 GC16P056609 RSPRY1 NUP93 POLR2C BBS2 MT1A MT1F
GH16J056603 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.7 -4.3 -4336 0.5 ELF3 PKNOX1 ARID4B SIN3A ZSCAN9 RAD21 RARA ZNF121 ZNF614 MIXL1 MT1G MT1H MT1B MT1X MT1A MT2A MT3
GH16J056589 Promoter/Enhancer 1.1 EPDnew Ensembl dbSUPER 0.4 -18.7 -18698 0.6 MXI1 BACH1 EZH2 MT3 MT1E MT2A
GH16J056605 Enhancer 0.6 ENCODE dbSUPER 0.7 -3.8 -3817 0.1 ZNF121 KAT7 MT1G MT1H MT1B MT1X MT1A MT2A MT3
GH16J056600 Enhancer 0.8 ENCODE dbSUPER 0.4 -7.6 -7615 0.2 CTCF TEAD1 CEBPB REST CEBPG RAD21 TEAD3 XRCC5 GATA2 CEBPA MT2A MT3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MT2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MT2A gene promoter:
  • GR-beta
  • GR-alpha
  • GR
  • AP-1
  • p53
  • STAT3
  • ATF-2

Genomic Locations for MT2A Gene

Genomic Locations for MT2A Gene
chr16:56,608,199-56,609,497
(GRCh38/hg38)
Size:
1,299 bases
Orientation:
Plus strand
chr16:56,642,111-56,643,409
(GRCh37/hg19)
Size:
1,299 bases
Orientation:
Plus strand

Genomic View for MT2A Gene

Genes around MT2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT2A Gene

ORGUL Member Location for MT2A Gene

ORGUL Member Location for MT2A gene

Proteins for MT2A Gene

  • Protein details for MT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02795-MT2_HUMAN
    Recommended name:
    Metallothionein-2
    Protein Accession:
    P02795
    Secondary Accessions:
    • Q14823
    • Q2HXR9
    • Q53XT9

    Protein attributes for MT2A Gene

    Size:
    61 amino acids
    Molecular mass:
    6042 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This metallothionein binds zinc.

    Three dimensional structures from OCA and Proteopedia for MT2A Gene

neXtProt entry for MT2A Gene

Post-translational modifications for MT2A Gene

  • Ubiquitination at isoforms=51
  • Modification sites at PhosphoSitePlus

Other Protein References for MT2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT2A Gene

Domains & Families for MT2A Gene

Gene Families for MT2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MT2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02795

UniProtKB/Swiss-Prot:

MT2_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT2A: view

Function for MT2A Gene

Molecular function for MT2A Gene

UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
GENATLAS Biochemistry:
metallothionein 2

Gene Ontology (GO) - Molecular Function for MT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12646258
GO:0008144 drug binding IDA 19536566
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding IEA,IBA --
genes like me logo Genes that share ontologies with MT2A: view
genes like me logo Genes that share phenotypes with MT2A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MT2A

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MT2A Gene

Localization for MT2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT2A gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3
cytoskeleton 1
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MT2A Gene

Pathways & Interactions for MT2A Gene

genes like me logo Genes that share pathways with MT2A: view

Pathways by source for MT2A Gene

Gene Ontology (GO) - Biological Process for MT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006878 cellular copper ion homeostasis TAS 6719135
GO:0006882 cellular zinc ion homeostasis IBA --
GO:0010038 response to metal ion TAS --
GO:0010273 detoxification of copper ion IBA --
GO:0035690 cellular response to drug IDA 19536566
genes like me logo Genes that share ontologies with MT2A: view

No data available for SIGNOR curated interactions for MT2A Gene

Drugs & Compounds for MT2A Gene

(19) Drugs for MT2A Gene - From: DrugBank, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2906
Copper Approved, Investigational Pharma Carrier, binder 202
Zinc Approved, Investigational Pharma Target 2430
Carboplatin Approved Pharma Enzyme, substrate Antitumor agent that forms platinum-DNA adducts., Platinum 2141
Oxaliplatin Approved, Investigational Pharma Enzyme, substrate Antitumor agent, Platinum 1560

(9) Additional Compounds for MT2A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MT2A: view

Transcripts for MT2A Gene

fRNAdb Secondary structures for MT2A Gene

  • FR000455

mRNA/cDNA for MT2A Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(231) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MT2A Gene

Metallothionein 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MT2A

Alternative Splicing Database (ASD) splice patterns (SP) for MT2A Gene

No ASD Table

Relevant External Links for MT2A Gene

GeneLoc Exon Structure for
MT2A
ECgene alternative splicing isoforms for
MT2A

Expression for MT2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT2A Gene

mRNA differential expression in normal tissues according to GTEx for MT2A Gene

This gene is overexpressed in Liver (x9.4).

Protein differential expression in normal tissues from HIPED for MT2A Gene

This gene is overexpressed in Fetal Liver (58.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MT2A Gene



Protein tissue co-expression partners for MT2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MT2A Gene:

MT2A

SOURCE GeneReport for Unigene cluster for MT2A Gene:

Hs.534330

Evidence on tissue expression from TISSUES for MT2A Gene

  • Liver(4.9)
  • Kidney(4.7)
  • Nervous system(4.7)
  • Stomach(3.4)
  • Muscle(2.9)
  • Heart(2.7)
  • Intestine(2.7)
  • Lung(2.6)
  • Adrenal gland(2.4)
  • Eye(2.1)
  • Spleen(2.1)
  • Gall bladder(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with MT2A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MT2A Gene

Orthologs for MT2A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT2A 34 33
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MT2A 34
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MT2 34
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mt1 34
  • 82 (a)
ManyToMany
Species where no ortholog for MT2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT2A Gene

ENSEMBL:
Gene Tree for MT2A (if available)
TreeFam:
Gene Tree for MT2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MT2A: view image

Paralogs for MT2A Gene

Paralogs for MT2A Gene

(14) SIMAP similar genes for MT2A Gene using alignment to 2 proteins:

  • MT2_HUMAN
  • H3BSP9_HUMAN
genes like me logo Genes that share paralogs with MT2A: view

Variants for MT2A Gene

Sequence variations from dbSNP and Humsavar for MT2A Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1001822139 -- 56,607,503(+) C/T upstream_transcript_variant
rs1001938051 -- 56,607,688(+) C/G upstream_transcript_variant
rs1006449317 -- 56,607,412(+) G/T upstream_transcript_variant
rs1007722906 -- 56,608,524(+) G/A upstream_transcript_variant
rs1007750167 -- 56,608,335(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MT2A Gene

Variant ID Type Subtype PubMed ID
esv2714516 CNV deletion 23290073

Variation tolerance for MT2A Gene

Residual Variation Intolerance Score: 64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MT2A Gene

Human Gene Mutation Database (HGMD)
MT2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT2A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT2A Gene

Disorders for MT2A Gene

MalaCards: The human disease database

(3) MalaCards diseases for MT2A Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
xeroderma pigmentosum, complementation group b
  • xpb
inverted papilloma
  • inverted papilloma, squamous cell
scrapie
- elite association - COSMIC cancer census association via MalaCards
Search MT2A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MT2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MT2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MT2A Gene

Publications for MT2A Gene

  1. The polymorphism of core promoter region on metallothionein 2A-metal binding protein in Turkish population. (PMID: 19572214) Kayaalti Z … Söylemezoğlu T (Molecular biology reports 2010) 3 22 44 58
  2. Expression of human metallothionein-II fusion protein in Escherichia coli. (PMID: 1339282) Yamazaki S … Kagawa Y (Biochemistry international 1992) 3 4 22 58
  3. Comparison of the solution conformations of human [Zn7]-metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy. (PMID: 1593628) Messerle BA … Wüthrich K (Journal of molecular biology 1992) 3 4 22 58
  4. Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy. (PMID: 2388267) Messerle BA … Wüthrich K (Journal of molecular biology 1990) 3 4 22 58
  5. Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene. (PMID: 7133118) Karin M … Richards RI (Nature 1982) 2 3 4 58

Products for MT2A Gene

Sources for MT2A Gene

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