Subcategory (RNA class) for MT2A Gene
Aliases for MT2A Gene
External Ids for MT2A Gene
ORGUL Members for MT2A Gene
Previous HGNC Symbols for MT2A Gene
Previous GeneCards Identifiers for MT2A Gene
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer. [provided by RefSeq, Sep 2017]
GeneCards Summary for MT2A Gene
MT2A (Metallothionein 2A) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with MT2A include Xeroderma Pigmentosum, Complementation Group B and Inverted Papilloma. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include drug binding. An important paralog of this gene is MT1G.
UniProtKB/Swiss-Prot for MT2A Gene
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
fRNAdb sequence ontologies for MT2A Gene
ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.