Aliases for MT2A Gene
External Ids for MT2A Gene
Previous HGNC Symbols for MT2A Gene
Previous GeneCards Identifiers for MT2A Gene
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer. [provided by RefSeq, Sep 2017]
GeneCards Summary for MT2A Gene
MT2A (Metallothionein 2A) is a Protein Coding gene. Diseases associated with MT2A include Menkes Disease and Osteogenesis Imperfecta, Type X. Among its related pathways are Response to metal ions and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include drug binding. An important paralog of this gene is MT1E.
UniProtKB/Swiss-Prot Summary for MT2A Gene
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.