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Aliases for MT1E Gene

Aliases for MT1E Gene

  • Metallothionein 1E 2 3 5
  • Metallothionein-IE 3 4
  • MT-1E 3 4
  • MT-IE 3 4
  • Metallothionein 1E (Functional) 3
  • Metallothionein-1E 3
  • Metallothionein D 3
  • MTD 3
  • MT1 3

External Ids for MT1E Gene

Previous HGNC Symbols for MT1E Gene

  • MT1

Previous GeneCards Identifiers for MT1E Gene

  • GC16U990040
  • GC16M056702
  • GC16P056387
  • GC16P056429
  • GC16P056435
  • GC16P055216
  • GC16P056659

Summaries for MT1E Gene

GeneCards Summary for MT1E Gene

MT1E (Metallothionein 1E) is a Protein Coding gene. Among its related pathways are Metallothioneins bind metals and Metabolism. An important paralog of this gene is MT1F.

UniProtKB/Swiss-Prot for MT1E Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Wiki entry for MT1E Gene

Additional gene information for MT1E Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1E Gene

Genomics for MT1E Gene

GeneHancer (GH) Regulatory Elements for MT1E Gene

Promoters and enhancers for MT1E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J056624 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 681.6 +0.8 779 3 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 YY1 ZNF213 ZNF143 FOS MT1E MT3 MT1G MT1H MT1B MT1F MT1X MT1A BBS2 NUP93
GH16J056604 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.4 -15.3 -15319 10.8 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 MT2A ENSG00000260823 GC16P056608 GC16P056609 RSPRY1 NUP93 POLR2C BBS2 MT1A MT1F
GH16J056616 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 10.9 -7.6 -7644 1.9 TAF1 RXRA SUZ12 MAX REST RAD21 YY1 SP1 POLR2A CTBP2 MT1A MT1L MT1F MT1G MT1H MT1CP MT1DP MT1B MT3 MT1E
GH16J056637 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 8.9 +13.1 13050 1.2 DRAP1 FOXA2 TAF1 SAP130 SUZ12 MAX ZNF48 RARA YY1 POLR2A MT1A MT1E MT1JP
GH16J056631 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 9.3 +7.0 6998 1.5 SP1 SUZ12 MXD3 ERF EZH2 YY1 MT1M MT1L MT1E CCL17 MT1JP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MT1E on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MT1E gene promoter:
  • TBP
  • GR-beta
  • GR-alpha
  • GR
  • Sp1
  • TFIID

Genomic Locations for MT1E Gene

Genomic Locations for MT1E Gene
chr16:56,625,475-56,627,112
(GRCh38/hg38)
Size:
1,638 bases
Orientation:
Plus strand
chr16:56,659,387-56,661,024
(GRCh37/hg19)
Size:
1,638 bases
Orientation:
Plus strand

Genomic View for MT1E Gene

Genes around MT1E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT1E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1E Gene

Proteins for MT1E Gene

  • Protein details for MT1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04732-MT1E_HUMAN
    Recommended name:
    Metallothionein-1E
    Protein Accession:
    P04732
    Secondary Accessions:
    • A2RRF7
    • Q86YX4
    • Q8TD51

    Protein attributes for MT1E Gene

    Size:
    61 amino acids
    Molecular mass:
    6014 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for MT1E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MT1E Gene

Post-translational modifications for MT1E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT1E Gene

No data available for DME Specific Peptides for MT1E Gene

Domains & Families for MT1E Gene

Gene Families for MT1E Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MT1E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04732

UniProtKB/Swiss-Prot:

MT1E_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1E: view

Function for MT1E Gene

Molecular function for MT1E Gene

UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
GENATLAS Biochemistry:
metallothionein 1E cluster

Phenotypes From GWAS Catalog for MT1E Gene

Gene Ontology (GO) - Molecular Function for MT1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding IBA,IEA --
genes like me logo Genes that share ontologies with MT1E: view
genes like me logo Genes that share phenotypes with MT1E: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MT1E

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MT1E Gene

Localization for MT1E Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT1E gene
Compartment Confidence
nucleus 5
extracellular 3
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MT1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8619255
GO:0005737 cytoplasm IDA 8619255
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1E: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1E Gene

Pathways & Interactions for MT1E Gene

genes like me logo Genes that share pathways with MT1E: view

Pathways by source for MT1E Gene

2 BioSystems pathways for MT1E Gene
1 KEGG pathway for MT1E Gene

Interacting Proteins for MT1E Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000307706%0d%0a9606.ENSP00000338345%0d%0a9606.ENSP00000398698%0d%0a
Selected Interacting proteins: P04732-MT1E_HUMAN ENSP00000307706 for MT1E Gene via IID STRING

Gene Ontology (GO) - Biological Process for MT1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006882 cellular zinc ion homeostasis IBA --
GO:0010273 detoxification of copper ion IBA --
GO:0045926 negative regulation of growth ISS --
GO:0050794 regulation of cellular process IBA --
GO:0071276 cellular response to cadmium ion IEP 16827180
genes like me logo Genes that share ontologies with MT1E: view

No data available for SIGNOR curated interactions for MT1E Gene

Drugs & Compounds for MT1E Gene

(4) Drugs for MT1E Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Carrier, binder 202
Silver Approved, Investigational Pharma Target, binder 0

(2) Additional Compounds for MT1E Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • CADMIUM ion
  • Cadmium, ion (CD2+)
  • CD(2+)
  • CD2+
  • Cadmium atom
7440-43-9
genes like me logo Genes that share compounds with MT1E: view

Transcripts for MT1E Gene

mRNA/cDNA for MT1E Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(231) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MT1E Gene

Metallothionein 1E:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MT1E

Alternative Splicing Database (ASD) splice patterns (SP) for MT1E Gene

No ASD Table

Relevant External Links for MT1E Gene

GeneLoc Exon Structure for
MT1E
ECgene alternative splicing isoforms for
MT1E

Expression for MT1E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT1E Gene

mRNA differential expression in normal tissues according to GTEx for MT1E Gene

This gene is overexpressed in Liver (x7.7).

Protein differential expression in normal tissues from HIPED for MT1E Gene

This gene is overexpressed in Liver, secretome (32.3) and Fetal Liver (29.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MT1E Gene



Protein tissue co-expression partners for MT1E Gene

NURSA nuclear receptor signaling pathways regulating expression of MT1E Gene:

MT1E

SOURCE GeneReport for Unigene cluster for MT1E Gene:

Hs.744893

Evidence on tissue expression from TISSUES for MT1E Gene

  • Liver(4.7)
  • Lung(4.3)
  • Kidney(2.7)
  • Stomach(2.4)
  • Nervous system(2.3)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with MT1E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MT1E Gene

Orthologs for MT1E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MT1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT1E 34
  • 93 (a)
OneToOne
Species where no ortholog for MT1E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1E Gene

ENSEMBL:
Gene Tree for MT1E (if available)
TreeFam:
Gene Tree for MT1E (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MT1E: view image

Paralogs for MT1E Gene

Paralogs for MT1E Gene

(14) SIMAP similar genes for MT1E Gene using alignment to 2 proteins:

  • MT1E_HUMAN
  • H3BU80_HUMAN

Pseudogenes.org Pseudogenes for MT1E Gene

genes like me logo Genes that share paralogs with MT1E: view

Variants for MT1E Gene

Sequence variations from dbSNP and Humsavar for MT1E Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000698207 -- 56,627,539(+) C/T downstream_transcript_variant
rs1001299403 -- 56,624,385(+) G/A upstream_transcript_variant
rs1001392547 -- 56,624,689(+) C/G upstream_transcript_variant
rs1004747675 -- 56,627,106(+) A/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1005200567 -- 56,624,077(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MT1E Gene

Variant ID Type Subtype PubMed ID
dgv524e214 CNV gain 21293372
nsv984339 CNV duplication 23825009

Variation tolerance for MT1E Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MT1E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT1E

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1E Gene

Disorders for MT1E Gene

Additional Disease Information for MT1E

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MT1E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1E Gene

Publications for MT1E Gene

  1. Induction by zinc of specific metallothionein isoforms in human monocytes. (PMID: 8119276) Pauwels M … De Ley M (European journal of biochemistry 1994) 3 4 22 58
  2. Structure and expression of two human metallothionein-I isoform genes and a related pseudogene. (PMID: 2581970) Schmidt CJ … Hamer DH (The Journal of biological chemistry 1985) 2 3 4 58
  3. Epigenetic alteration of the metallothionein 1E gene in human endometrial carcinomas. (PMID: 19420986) Tse KY … Ngan HY (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2009) 3 22 58
  4. Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications. (PMID: 18349110) Yang L … Liu Y (American journal of physiology. Endocrinology and metabolism 2008) 3 44 58
  5. Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration. (PMID: 18724390) Wu Y … Theodorescu D (Oncogene 2008) 3 22 58

Products for MT1E Gene

Sources for MT1E Gene

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