Aliases for MT1A Gene
External Ids for MT1A Gene
Previous HGNC Symbols for MT1A Gene
Previous GeneCards Identifiers for MT1A Gene
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017]
GeneCards Summary for MT1A Gene
MT1A (Metallothionein 1A) is a Protein Coding gene. Among its related pathways are Metabolism and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. An important paralog of this gene is MT1E.
UniProtKB/Swiss-Prot for MT1A Gene
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.