This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important ... See more...

Aliases for MT1A Gene

Aliases for MT1A Gene

  • Metallothionein 1A 2 3 5
  • Metallothionein 1S 2 3
  • Metallothionein-1A 3 4
  • Metallothionein-IA 3 4
  • MT-1A 3 4
  • MT-IA 3 4
  • MT1S 3 4
  • Metallothionein 1A (Functional) 3
  • MT1A 5
  • MT1 3
  • MTC 3

External Ids for MT1A Gene

Previous HGNC Symbols for MT1A Gene

  • MT1
  • MT1S

Previous GeneCards Identifiers for MT1A Gene

  • GC16P047056
  • GC16M056723
  • GC16P056405
  • GC16P056442
  • GC16P056447
  • GC16P055230
  • GC16P056672
  • GC16P042542

Summaries for MT1A Gene

Entrez Gene Summary for MT1A Gene

  • This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017]

GeneCards Summary for MT1A Gene

MT1A (Metallothionein 1A) is a Protein Coding gene. Diseases associated with MT1A include Pthirus Pubis Infestation and Lice Infestation. Among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Metal ion SLC transporters. An important paralog of this gene is MT2A.

UniProtKB/Swiss-Prot Summary for MT1A Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Wiki entry for MT1A Gene

Additional gene information for MT1A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MT1A Gene

Genomics for MT1A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MT1A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J056616 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 612.3 -20.8 -20835 1.9 SP1 EZH2 YY1 POLR2A RAD21 RXRA MAX REST TAF1 MT1A MT1L MT1F MT1G MT1H MT1CP MT1DP MT1B MT3 MT1E
GH16J056637 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 609.8 -0.1 -141 1.2 REST RXRB SP1 EZH2 NRF1 TAF1 FOXA2 YY1 NR2F2 SAP130 MT1A MT1E MT1JP MT1M
GH16J056639 Enhancer 0.5 ENCODE 600.7 +0.6 578 0.2 EZH2 ZBTB44 FOXA2 HNF4A RXRA SP1 MT1A MT1E MT1DP MT1L lnc-MT1A-1 MT1B
GH16J056604 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.4 -28.5 -28510 10.8 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST TFE3 IKZF1 NFKBIZ MT2A ENSG00000260823 NONHSAG019534.2 RSPRY1 BBS2 MT1A MT1F NUDT21 MT1G MT1H
GH16J056518 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -119.0 -119021 3.1 RFX1 ZNF692 POLR2A BACH1 LARP7 ZNF143 ZIC2 RBFOX2 RXRB PATZ1 BBS2 OGFOD1 MT3 MT1G MT1H MT1A NUDT21 MT4 lnc-NUDT21-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MT1A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MT1A

Top Transcription factor binding sites by QIAGEN in the MT1A gene promoter:
  • p53
  • Sp1
  • TBP
  • TFIID

Genomic Locations for MT1A Gene

Genomic Locations for MT1A Gene
chr16:56,638,666-56,640,087
(GRCh38/hg38)
Size:
1,422 bases
Orientation:
Plus strand
chr16:56,672,578-56,673,999
(GRCh37/hg19)
Size:
1,422 bases
Orientation:
Plus strand

Genomic View for MT1A Gene

Genes around MT1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1A Gene

Proteins for MT1A Gene

  • Protein details for MT1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04731-MT1A_HUMAN
    Recommended name:
    Metallothionein-1A
    Protein Accession:
    P04731
    Secondary Accessions:
    • Q86YX5

    Protein attributes for MT1A Gene

    Size:
    61 amino acids
    Molecular mass:
    6120 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for MT1A Gene

Post-translational modifications for MT1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1A Gene

Domains & Families for MT1A Gene

Gene Families for MT1A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MT1A Gene

GenScript: Design optimal peptide antigens:
  • Metallothionein-IA (MT1A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04731

UniProtKB/Swiss-Prot:

MT1A_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1A: view

Function for MT1A Gene

Molecular function for MT1A Gene

UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
GENATLAS Biochemistry:
metallothionein 1A cluster

Gene Ontology (GO) - Molecular Function for MT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16442532
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding IBA 21873635
genes like me logo Genes that share ontologies with MT1A: view
genes like me logo Genes that share phenotypes with MT1A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MT1A

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MT1A Gene

Localization for MT1A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT1A gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
endosome 1

Gene Ontology (GO) - Cellular Components for MT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IBA,ISS --
GO:0005737 cytoplasm IBA,ISS --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MT1A Gene

Pathways & Interactions for MT1A Gene

genes like me logo Genes that share pathways with MT1A: view

Pathways by source for MT1A Gene

2 BioSystems pathways for MT1A Gene
1 PharmGKB pathway for MT1A Gene
1 KEGG pathway for MT1A Gene

Gene Ontology (GO) - Biological Process for MT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006882 cellular zinc ion homeostasis IBA 21873635
GO:0010038 response to metal ion TAS --
GO:0010273 detoxification of copper ion IBA 21873635
GO:0045926 negative regulation of growth ISS --
GO:0071276 cellular response to cadmium ion IEP 16827180
genes like me logo Genes that share ontologies with MT1A: view

No data available for SIGNOR curated interactions for MT1A Gene

Drugs & Compounds for MT1A Gene

(13) Drugs for MT1A Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Carrier, binder 249
Zinc Approved, Investigational Pharma Target 1594
Carboplatin Approved Pharma Enzyme, substrate Antitumor agent that forms platinum-DNA adducts., Platinum 2588
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3412
Nitric Oxide Approved Pharma Target 771

(3) Additional Compounds for MT1A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for MT1A Gene

Compound Action Cas Number
Agomelatine MT1/MT2 / 5-HT2C agonist 138112-76-2
genes like me logo Genes that share compounds with MT1A: view

Drug Products

Transcripts for MT1A Gene

mRNA/cDNA for MT1A Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MT1A

Alternative Splicing Database (ASD) splice patterns (SP) for MT1A Gene

No ASD Table

Relevant External Links for MT1A Gene

GeneLoc Exon Structure for
MT1A

Expression for MT1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MT1A Gene

mRNA differential expression in normal tissues according to GTEx for MT1A Gene

This gene is overexpressed in Liver (x10.8) and Adipose - Visceral (Omentum) (x6.7).

Protein differential expression in normal tissues from HIPED for MT1A Gene

This gene is overexpressed in Liver (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MT1A Gene



Protein tissue co-expression partners for MT1A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MT1A

SOURCE GeneReport for Unigene cluster for MT1A Gene:

Hs.655199

Evidence on tissue expression from TISSUES for MT1A Gene

  • Liver(4.8)
  • Intestine(3.7)
  • Kidney(3.6)
  • Nervous system(3.4)
  • Muscle(3.3)
  • Stomach(3.2)
  • Pancreas(3.1)
  • Blood(2.6)
  • Heart(2.6)
  • Thyroid gland(2.6)
  • Skin(2.5)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with MT1A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MT1A Gene

Orthologs for MT1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT1A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MT1A 31
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mt1 31
  • 82 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia MT1E 31
  • 79 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 77 (a)
ManyToMany
Species where no ortholog for MT1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MT1A Gene

ENSEMBL:
Gene Tree for MT1A (if available)
TreeFam:
Gene Tree for MT1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MT1A: view image

Paralogs for MT1A Gene

Paralogs for MT1A Gene

(12) SIMAP similar genes for MT1A Gene using alignment to 1 proteins:

  • MT1A_HUMAN
genes like me logo Genes that share paralogs with MT1A: view

Variants for MT1A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MT1A Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs11640851 - p.Thr27Asn
rs8052394 - p.Lys51Arg

Additional dbSNP identifiers (rs#s) for MT1A Gene

Structural Variations from Database of Genomic Variants (DGV) for MT1A Gene

Variant ID Type Subtype PubMed ID
dgv2988n100 CNV gain 25217958
dgv2989n100 CNV gain 25217958
dgv524e214 CNV gain 21293372
esv2669588 CNV deletion 23128226
esv3638704 CNV loss 21293372
nsv1058153 CNV gain 25217958
nsv572696 CNV loss 21841781

Variation tolerance for MT1A Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.59; 93.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MT1A Gene

Human Gene Mutation Database (HGMD)
MT1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT1A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1A Gene

Disorders for MT1A Gene

MalaCards: The human disease database

(5) MalaCards diseases for MT1A Gene - From: DISEASES

Disorder Aliases PubMed IDs
pthirus pubis infestation
  • crabs
lice infestation
  • infestation by pediculus
parasitic ectoparasitic infectious disease
  • ectoparasitism
metal metabolism disorder
  • inborn metal metabolism disorder
cone-rod dystrophy 2
  • cord2
- elite association - COSMIC cancer census association via MalaCards
Search MT1A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MT1A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MT1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MT1A Gene

Publications for MT1A Gene

  1. Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. (PMID: 6327055) Richards RI … Karin M (Cell 1984) 2 3 4
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41
  3. Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population: comparison with an Italian cohort. (PMID: 19962295) Giacconi R … Mocchegiani E (The Journal of nutritional biochemistry 2010) 3 41
  4. Genetic background of lead and mercury metabolism in a group of medical students in Austria. (PMID: 19515364) Gundacker C … Gencik M (Environmental research 2009) 3 41
  5. Metallothionein I isoform mRNA expression in peripheral lymphocytes as a biomarker for occupational cadmium exposure. (PMID: 19359654) Chang X … Lei L (Experimental biology and medicine (Maywood, N.J.) 2009) 3 23

Products for MT1A Gene

Sources for MT1A Gene