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Aliases for MT-TL2 Gene

Subcategory (RNA class) for MT-TL2 Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for MT-TL2 Gene

  • Mitochondrially Encoded TRNA Leucine 2 (CUN) 2 5
  • TRNA Leucine 2 (CUN) 2
  • TRNL2 3
  • MTTL2 3
  • TRNA 3

External Ids for MT-TL2 Gene

Previous HGNC Symbols for MT-TL2 Gene

  • MTTL2

Previous GeneCards Identifiers for MT-TL2 Gene

  • GC00U921606

Summaries for MT-TL2 Gene

GeneCards Summary for MT-TL2 Gene

MT-TL2 (Mitochondrially Encoded TRNA Leucine 2 (CUN)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MT-TL2 include Mitochondrial Myopathy and Mitochondrial Disorders. Among its related pathways are tRNA Aminoacylation.

Additional gene information for MT-TL2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-TL2 Gene

Genomics for MT-TL2 Gene

Genomic Locations for MT-TL2 Gene

Genomic Locations for MT-TL2 Gene
71 bases
Plus strand

Genomic View for MT-TL2 Gene

Genes around MT-TL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT-TL2 Gene

No data available for GeneHancer (GH) Regulatory Elements for MT-TL2 Gene

Proteins for MT-TL2 Gene

Post-translational modifications for MT-TL2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT-TL2 Gene

Domains & Families for MT-TL2 Gene

Gene Families for MT-TL2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MT-TL2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MT-TL2 Gene

Function for MT-TL2 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT-TL2 Gene

Localization for MT-TL2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT-TL2 gene
Compartment Confidence
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MT-TL2 Gene

Pathways & Interactions for MT-TL2 Gene

SuperPathways for MT-TL2 Gene

SuperPathway Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with MT-TL2: view

Pathways by source for MT-TL2 Gene

1 KEGG pathway for MT-TL2 Gene

Interacting Proteins for MT-TL2 Gene

Gene Ontology (GO) - Biological Process for MT-TL2 Gene


No data available for SIGNOR curated interactions for MT-TL2 Gene

Drugs & Compounds for MT-TL2 Gene

No Compound Related Data Available

Transcripts for MT-TL2 Gene

mRNA/cDNA for MT-TL2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT-TL2 Gene

No ASD Table

Relevant External Links for MT-TL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MT-TL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT-TL2 Gene

mRNA differential expression in normal tissues according to GTEx for MT-TL2 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x6.5), Brain - Putamen (basal ganglia) (x6.5), and Brain - Substantia nigra (x5.8).
genes like me logo Genes that share expression patterns with MT-TL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MT-TL2 Gene

Orthologs for MT-TL2 Gene

Evolution for MT-TL2 Gene

Gene Tree for MT-TL2 (if available)
Gene Tree for MT-TL2 (if available)

No data available for Orthologs for MT-TL2 Gene

Paralogs for MT-TL2 Gene

No data available for Paralogs for MT-TL2 Gene

Variants for MT-TL2 Gene

Additional Variant Information for MT-TL2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT-TL2 Gene

Disorders for MT-TL2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MT-TL2 Gene - From: HGMD, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mitochondrial myopathy
  • mitochondrial cytopathy
mitochondrial disorders
  • mitochondrial encephalomyopathies
maternally-inherited progressive external ophthalmoplegia
  • maternally-inherited cpeo
mitochondrial encephalomyopathy
  • mitochondrial encephalomyopathies
mitochondrial metabolism disease
  • mitochondrial diseases
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MT-TL2: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for MT-TL2 Gene

Publications for MT-TL2 Gene

  1. Clinical and cellular consequences of the mutation m.12300G>A in the mitochondrial tRNA(Leu(CUN)) gene. (PMID: 22094595) Martín-Jiménez R … Campos Y (Mitochondrion 2012) 3 58
  2. Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations. (PMID: 20064630) Nishigaki Y … Tanaka M (Mitochondrion 2010) 3 58
  3. Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss. (PMID: 20111055) Kato T … Tanaka M (Journal of human genetics 2010) 3 58
  4. Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort. (PMID: 20538375) Lakatos A … Alzheimer's Disease Neuroimaging Initiative (Neurobiology of aging 2010) 3 58
  5. Involvement of mitochondrial DNA sequence variations and respiratory activity in late complications following radiotherapy. (PMID: 19920115) Alsbeih GA … Abu-Amero KK (Clinical cancer research : an official journal of the American Association for Cancer Research 2009) 3 58

Products for MT-TL2 Gene

Sources for MT-TL2 Gene

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