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Aliases for MT-TK Gene

Subcategory (RNA class) for MT-TK Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for MT-TK Gene

  • Mitochondrially Encoded TRNA Lysine 2 5
  • TRNA Lysine 2
  • TRNA 3
  • TRNK 3
  • MTTK 3

External Ids for MT-TK Gene

Previous HGNC Symbols for MT-TK Gene

  • MTTK

Previous GeneCards Identifiers for MT-TK Gene

  • GC00U921604

Summaries for MT-TK Gene

GeneCards Summary for MT-TK Gene

MT-TK (Mitochondrially Encoded TRNA Lysine) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MT-TK include Myoclonic Epilepsy Associated With Ragged-Red Fibers and Diabetes And Deafness, Maternally Inherited. Among its related pathways are tRNA Aminoacylation.

Additional gene information for MT-TK Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-TK Gene

Genomics for MT-TK Gene

Genomic Locations for MT-TK Gene

Genomic Locations for MT-TK Gene
70 bases
Plus strand

Genomic View for MT-TK Gene

Genes around MT-TK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT-TK Gene

No data available for GeneHancer (GH) Regulatory Elements for MT-TK Gene

Proteins for MT-TK Gene

Post-translational modifications for MT-TK Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT-TK Gene

Domains & Families for MT-TK Gene

Gene Families for MT-TK Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MT-TK: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MT-TK Gene

Function for MT-TK Gene

Human Phenotype Ontology for MT-TK Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT-TK Gene

Localization for MT-TK Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT-TK gene
Compartment Confidence
mitochondrion 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MT-TK Gene

Pathways & Interactions for MT-TK Gene

SuperPathways for MT-TK Gene

SuperPathway Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with MT-TK: view

Pathways by source for MT-TK Gene

1 KEGG pathway for MT-TK Gene

Interacting Proteins for MT-TK Gene

Gene Ontology (GO) - Biological Process for MT-TK Gene


No data available for SIGNOR curated interactions for MT-TK Gene

Drugs & Compounds for MT-TK Gene

No Compound Related Data Available

Transcripts for MT-TK Gene

mRNA/cDNA for MT-TK Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT-TK Gene

No ASD Table

Relevant External Links for MT-TK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MT-TK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT-TK Gene

Evidence on tissue expression from TISSUES for MT-TK Gene

  • Muscle(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MT-TK Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • meninges
  • neck
  • heart
  • heart valve
  • lung
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • penis
  • rectum
  • lower limb
  • blood
  • blood vessel
  • coagulation system
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with MT-TK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MT-TK Gene

Orthologs for MT-TK Gene

Evolution for MT-TK Gene

Gene Tree for MT-TK (if available)
Gene Tree for MT-TK (if available)

No data available for Orthologs for MT-TK Gene

Paralogs for MT-TK Gene

No data available for Paralogs for MT-TK Gene

Variants for MT-TK Gene

Additional Variant Information for MT-TK Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT-TK Gene

Disorders for MT-TK Gene

MalaCards: The human disease database

(27) MalaCards diseases for MT-TK Gene - From: HGMD, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MT-TK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MT-TK

Genetic Association Database
genes like me logo Genes that share disorders with MT-TK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MT-TK Gene

Publications for MT-TK Gene

  1. Common mitochondrial DNA and POLG1 mutations are rare in the Chinese patients with adult-onset ataxia on Taiwan. (PMID: 17300808) Lee YC … Soong BW (Journal of the neurological sciences 2007) 3 44 58
  2. Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients. (PMID: 17619138) Ahari SE … Bahar MA (Cellular and molecular neurobiology 2007) 3 44 58
  3. Detection of common disease-causing mutations in mitochondrial DNA (mitochondrial encephalomyopathy, lactic acidosis with stroke-like episodes MTTL1 3243 A>G and myoclonic epilepsy associated with ragged-red fibers MTTK 8344A>G) by real-time polymerase chain reaction. (PMID: 16645216) Fan H … Farber RA (The Journal of molecular diagnostics : JMD 2006) 3 44 58
  4. Diagnostic screening of mitochondrial DNA mutations in Australian adults 1990-2001. (PMID: 14748908) Marotta R … Collins S (Internal medicine journal 2004) 3 44 58
  5. Expanded phenotypic spectrum of the m.8344A>G "MERRF" mutation: data from the German mitoNET registry. (PMID: 26995359) Altmann J … Klopstock T (Journal of neurology 2016) 3 58

Products for MT-TK Gene

Sources for MT-TK Gene

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