Aliases for MT-TG Gene

Data sources for MT-TG Gene:

RNA type for MT-TG Gene

tRNA

Aliases for MT-TG Gene

External Ids for MT-TG Gene

Previous HGNC Symbols for MT-TG Gene

  • MTTG

Previous GeneCards Identifiers for MT-TG Gene

  • GC00U921601

Summaries for MT-TG Gene

GeneCards Summary for MT-TG Gene

MT-TG (Mitochondrially Encoded TRNA-Gly (GGN)) is an RNA Gene, and is affiliated with the tRNA class. Diseases associated with MT-TG include Cardiomyopathy, Familial Hypertrophic, 1 and Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes. Among its related pathways are tRNA Aminoacylation.

Additional gene information for MT-TG Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MT-TG Gene

Genomics for MT-TG Gene

Genomic Locations for MT-TG Gene

Latest Assembly
chrMT:9,988-10,059
(GRCh38/hg38)
Size:
72 bases
Orientation:
Plus strand

Previous Assembly
chrMT:9,991-10,058
(GRCh37/hg19 by Ensembl)
Size:
68 bases
Orientation:
Plus strand

Genomic View for MT-TG Gene

Genes around MT-TG on UCSC Golden Path with GeneCards custom track
MT-TG in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT-TG Gene

No data available for GeneHancer (GH) Regulatory Elements for MT-TG Gene

Proteins for MT-TG Gene

Post-translational modifications for MT-TG Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT-TG Gene

Domains & Families for MT-TG Gene

Gene Families for MT-TG Gene

genes like me logo Genes that share domains with MT-TG: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MT-TG Gene

Function for MT-TG Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT-TG Gene

Localization for MT-TG Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT-TG gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MT-TG Gene

Pathways & Interactions for MT-TG Gene

PathCards logo

SuperPathways for MT-TG Gene

SuperPathway Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with MT-TG: view

Pathways by source for MT-TG Gene

1 KEGG pathway for MT-TG Gene

Gene Ontology (GO) - Biological Process for MT-TG Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MT-TG Gene

Drugs & Compounds for MT-TG Gene

No Compound Related Data Available

Transcripts for MT-TG Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MT-TG Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00000C6674_9606 tRNA 68 2

Ensembl: ENST00000387429 (view in UCSC) ,

ENA: View 51168 records in RNAcentral

URS00002B3D67_9606 tRNA 71 1

ENA: JN580302.1:9990..10060:tRNA,

URS000001B2EC_9606 tRNA 68 1

ENA: S73514.1:1..68:tRNA,

URS00000288A9_9606 tRNA 68 1

ENA: View 9 records in RNAcentral

URS0000035AA4_9606 tRNA 68 1

ENA: JF824949.2:9991..10058:tRNA,

MT-TG in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MT-TG Gene

No ASD Table

Relevant External Links for MT-TG Gene

GeneLoc Exon Structure for
MT-TG

No data available for mRNA/cDNA for MT-TG Gene

Expression for MT-TG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MT-TG Gene

mRNA differential expression in normal tissues according to GTEx for MT-TG Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x9.0) and Brain - Caudate (basal ganglia) (x6.7).
genes like me logo Genes that share expression patterns with MT-TG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MT-TG Gene

Orthologs for MT-TG Gene

Evolution for MT-TG Gene

ENSEMBL:
Gene Tree for MT-TG (if available)
TreeFam:
Gene Tree for MT-TG (if available)
Alliance of Genome Resources:
Additional Orthologs for MT-TG

No data available for Orthologs for MT-TG Gene

Paralogs for MT-TG Gene

No data available for Paralogs for MT-TG Gene

Variants for MT-TG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MT-TG Gene

SNP ID Clinical significance and condition Chr MT pos Variation AA Info Type
430677 Pathogenic: Mitochondrial diseases 7,729(+) AAAACTAACTAATACT
NC_012920.1:m.7730_11255del3526
INITIATIOR_CODON_VARIANT,FRAMESHIFT
638146 Pathogenic: Pearson syndrome 8,479(+) ACCAAAGCCCATAAAA
NC_012920.1:m.8480_13440del
INITIATIOR_CODON_VARIANT,FRAMESHIFT
rs121434475 Likely Pathogenic: Juvenile myopathy, encephalopathy, lactic acidosis AND stroke. Pathogenic: Primary familial hypertrophic cardiomyopathy 9,997(+) T/AT/C
NC_012920.1(MT-CYB):m.9997T>A
rs121434476 Pathogenic: Exercise intolerance 10,010(+) T/C
m.10010T>C
rs1556423755 Uncertain Significance: Juvenile myopathy, encephalopathy, lactic acidosis AND stroke 9,996(+) T/C
NC_012920.1(MT-CYB):m.9996T>C

Additional Variant Information for MT-TG Gene

Human Gene Mutation Database (HGMD)
MT-TG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT-TG
Leiden Open Variation Database (LOVD)
MT-TG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT-TG Gene

Disorders for MT-TG Gene

MalaCards: The human disease database

(16) MalaCards diseases for MT-TG Gene - From: CVR, COP, and GCD

genes like me logo Genes that share disorders with MT-TG: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for MT-TG Gene

Publications for MT-TG Gene

  1. Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's disease. (PMID: 16784756) Swerdlow RH … Worrall BB (Journal of the neurological sciences 2006) 3 40
  2. Mitochondrial DNA A4336G mutation in Alzheimer's and Parkinson's diseases. (PMID: 12138308) García-Lozano JR … Núñez-Roldan A (European neurology 2002) 3 40
  3. Interpretation of mitochondrial tRNA variants. (PMID: 31965079) Wong LC … Craigen WJ (Genetics in medicine : official journal of the American College of Medical Genetics 2020) 72
  4. Molecular characterization of a pedigree carrying the hypertension‑associated mitochondrial tRNAGln T4363C mutation. (PMID: 28849157) Wang L … Xu J (Molecular medicine reports 2017) 3
  5. Mitochondrial tRNA(Glu) A14693G variant may modulate the phenotypic manifestation of deafness-associated 12S rRNA A1555G mutation in a Han Chinese family. (PMID: 19376484) Ding Y … Guan MX (Journal of genetics and genomics = Yi chuan xue bao 2009) 3

Products for MT-TG Gene

Sources for MT-TG Gene