Aliases for MT-ND4 Gene
External Ids for MT-ND4 Gene
Previous HGNC Symbols for MT-ND4 Gene
Previous GeneCards Identifiers for MT-ND4 Gene
GeneCards Summary for MT-ND4 Gene
MT-ND4 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 4) is a Protein Coding gene. Diseases associated with MT-ND4 include Leber Optic Atrophy and Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and GABAergic synapse. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity. An important paralog of this gene is MT-ND5.
UniProtKB/Swiss-Prot Summary for MT-ND4 Gene
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).