Aliases for MT-ATP8 Gene
External Ids for MT-ATP8 Gene
Previous HGNC Symbols for MT-ATP8 Gene
Previous GeneCards Identifiers for MT-ATP8 Gene
GeneCards Summary for MT-ATP8 Gene
MT-ATP8 (Mitochondrially Encoded ATP Synthase Membrane Subunit 8) is a Protein Coding gene. Diseases associated with MT-ATP8 include Cardiomyopathy, Infantile Hypertrophic and Periodic Paralysis With Later-Onset Distal Motor Neuropathy. Among its related pathways are Pathways of neurodegeneration - multiple diseases and purine nucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include ATPase activity and proton transmembrane transporter activity.
UniProtKB/Swiss-Prot Summary for MT-ATP8 Gene
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).