Aliases for MT-ATP8 Gene
External Ids for MT-ATP8 Gene
Previous HGNC Symbols for MT-ATP8 Gene
Previous GeneCards Identifiers for MT-ATP8 Gene
GeneCards Summary for MT-ATP8 Gene
MT-ATP8 (Mitochondrially Encoded ATP Synthase Membrane Subunit 8) is a Protein Coding gene. Diseases associated with MT-ATP8 include Isolated Atp Synthase Deficiency and Periodic Paralysis With Later-Onset Distal Motor Neuropathy. Among its related pathways are Metabolism and purine nucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include ATPase activity and proton transmembrane transporter activity.
UniProtKB/Swiss-Prot for MT-ATP8 Gene
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).