Aliases for MSTN Gene
External Ids for MSTN Gene
Previous HGNC Symbols for MSTN Gene
Previous GeneCards Identifiers for MSTN Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]
GeneCards Summary for MSTN Gene
MSTN (Myostatin) is a Protein Coding gene. Diseases associated with MSTN include Muscle Hypertrophy and Myostatin-Related Muscle Hypertrophy. Among its related pathways are PEDF Induced Signaling and Hypertrophy Model. Gene Ontology (GO) annotations related to this gene include identical protein binding and cytokine activity. An important paralog of this gene is GDF11.
UniProtKB/Swiss-Prot Summary for MSTN Gene
Acts specifically as a negative regulator of skeletal muscle growth.