This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the... See more...

Aliases for MST1R Gene

Aliases for MST1R Gene

  • Macrophage Stimulating 1 Receptor 2 3 5
  • CDw136 2 3 4
  • S13 Avian Erythroblastosis Oncogene Homolog 2 3
  • Macrophage-Stimulating Protein Receptor 3 4
  • PTK8 Protein Tyrosine Kinase 8 2 3
  • C-Met-Related Tyrosine Kinase 2 3
  • MSP Receptor 3 4
  • EC 2.7.10.1 4 50
  • P185-Ron 3 4
  • CD136 2 3
  • PTK8 3 4
  • RON 3 4
  • S13 Erythroblastosis (Avian) Oncogene Homolog 2
  • S13 Erythroblastosis Oncogene Homolog 3
  • Protein-Tyrosine Kinase 8 4
  • CD136 Antigen 4
  • EC 2.7.10 50
  • NPCA3 3
  • MST1R 5
  • SEA 3

External Ids for MST1R Gene

Previous HGNC Symbols for MST1R Gene

  • RON
  • PTK8
  • SEA

Previous GeneCards Identifiers for MST1R Gene

  • GC03P050091
  • GC03P050215
  • GC03M049778
  • GC03M049884
  • GC03M049885
  • GC03M049899
  • GC03M049924
  • GC03M049888
  • GC03M049894
  • GC03M049958
  • GC03M049998

Summaries for MST1R Gene

Entrez Gene Summary for MST1R Gene

  • This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]

GeneCards Summary for MST1R Gene

MST1R (Macrophage Stimulating 1 Receptor) is a Protein Coding gene. Diseases associated with MST1R include Nasopharyngeal Carcinoma 3 and Nasopharyngeal Carcinoma. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MET.

UniProtKB/Swiss-Prot Summary for MST1R Gene

  • Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Gene Wiki entry for MST1R Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MST1R Gene

Genomics for MST1R Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MST1R Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MST1R on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MST1R

Top Transcription factor binding sites by QIAGEN in the MST1R gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • NF-kappaB
  • NF-kappaB1
  • STAT3
  • STAT5A

Genomic Locations for MST1R Gene

Latest Assembly
chr3:49,886,471-49,903,873
(GRCh38/hg38)
Size:
17,403 bases
Orientation:
Minus strand

Previous Assembly
chr3:49,924,435-49,941,306
(GRCh37/hg19 by Entrez Gene)
Size:
16,872 bases
Orientation:
Minus strand

chr3:49,924,435-49,941,299
(GRCh37/hg19 by Ensembl)
Size:
16,865 bases
Orientation:
Minus strand

Genomic View for MST1R Gene

Genes around MST1R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MST1R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MST1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MST1R Gene

Proteins for MST1R Gene

  • Protein details for MST1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04912-RON_HUMAN
    Recommended name:
    Macrophage-stimulating protein receptor
    Protein Accession:
    Q04912
    Secondary Accessions:
    • A0A087WZG2
    • B5A944
    • B5A945
    • B5A946
    • B5A947

    Protein attributes for MST1R Gene

    Size:
    1400 amino acids
    Molecular mass:
    152241 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion.
    Miscellaneous:
    • [Isoform Delta-RON]: Lacks part of the extracellular domain, oligomerizes and is constitutively activated. Expressed at higher level in cancer cells.

    Three dimensional structures from OCA and Proteopedia for MST1R Gene

    Alternative splice isoforms for MST1R Gene

neXtProt entry for MST1R Gene

Selected DME Specific Peptides for MST1R Gene

Q04912:
  • QVARGME
  • RDLAARN
  • LPVKWMA
  • QPEYCPD
  • FTVKVADFGLAR
  • KSDVWSFG
  • WMALESL
  • FVHRDLA
  • DFGLARDI

Post-translational modifications for MST1R Gene

  • Proteolytic processing yields the two subunits.
  • Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site.
  • Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation.
  • Glycosylation at Asn66, Asn419, Asn458, Asn488, Asn654, Asn720, Asn841, and Asn897
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for MST1R

Domains & Families for MST1R Gene

Gene Families for MST1R Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MST1R Gene

GenScript: Design optimal peptide antigens:
  • p185-Ron (RON_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q04912

UniProtKB/Swiss-Prot:

RON_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with MST1R: view

Function for MST1R Gene

Molecular function for MST1R Gene

UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};.
UniProtKB/Swiss-Prot EnzymeRegulation:
In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.
GENATLAS Biochemistry:
macrophage stimulating protein 1 receptor,hepacyte growth factor receptor (MET) related,involved in development of epithelial tissue,bone,neuroendocrine derivatives,paralog to MET,stem cell tyrosine kinase receptor (Stk) homolog,conferring susceptibility to friend virus induced erythroleukemia in mice

Enzyme Numbers (IUBMB) for MST1R Gene

Phenotypes From GWAS Catalog for MST1R Gene

Gene Ontology (GO) - Molecular Function for MST1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IBA 21873635
GO:0005011 macrophage colony-stimulating factor receptor activity TAS 9045873
genes like me logo Genes that share ontologies with MST1R: view
genes like me logo Genes that share phenotypes with MST1R: view

Human Phenotype Ontology for MST1R Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MST1R Gene

MGI Knock Outs for MST1R:

miRNA for MST1R Gene

miRTarBase miRNAs that target MST1R

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MST1R

No data available for Transcription Factor Targets and HOMER Transcription for MST1R Gene

Localization for MST1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for MST1R Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MST1R gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MST1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
GO:0005773 vacuole IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0009925 basal plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with MST1R: view

Pathways & Interactions for MST1R Gene

PathCards logo

SuperPathways for MST1R Gene

SuperPathway Contained pathways
1 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
2 ERK Signaling
.61
.61
.58
.51
.49
3 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
4 Actin Nucleation by ARP-WASP Complex
.66
.66
.41
5 Activation of cAMP-Dependent PKA
.77
.71
genes like me logo Genes that share pathways with MST1R: view

Pathways by source for MST1R Gene

2 BioSystems pathways for MST1R Gene
2 Reactome pathways for MST1R Gene
1 KEGG pathway for MST1R Gene
30 Qiagen pathways for MST1R Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
2 Cell Signaling Technology pathways for MST1R Gene

SIGNOR curated interactions for MST1R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MST1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006909 phagocytosis IBA 21873635
GO:0006952 defense response TAS 9045873
GO:0007165 signal transduction TAS 7939629
genes like me logo Genes that share ontologies with MST1R: view

Drugs & Compounds for MST1R Gene

(10) Drugs for MST1R Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
foretinib Investigational Pharma inhibitor Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
ATP Investigational Nutra 0
macrophage stimulating protein 1 Pharma 0
Foretinib (GSK1363089) Pharma VEGF and HGF receptor inhibitor 0

(3) Additional Compounds for MST1R Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0

(2) ApexBio Compounds for MST1R Gene

Compound Action Cas Number
Foretinib (GSK1363089) VEGF and HGF receptor inhibitor 849217-64-7
MGCD-265 Met/Flt/Flk/Ron/Tie-2 inhibitor 875337-44-3
genes like me logo Genes that share compounds with MST1R: view

Drug products for research

Transcripts for MST1R Gene

mRNA/cDNA for MST1R Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MST1R

Alternative Splicing Database (ASD) splice patterns (SP) for MST1R Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for MST1R Gene

GeneLoc Exon Structure for
MST1R

Expression for MST1R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MST1R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MST1R Gene

This gene is overexpressed in Colon - Transverse (x7.7), Stomach (x6.1), Skin - Sun Exposed (Lower leg) (x5.4), and Skin - Not Sun Exposed (Suprapubic) (x5.3).

Protein differential expression in normal tissues from HIPED for MST1R Gene

This gene is overexpressed in Stomach (40.3) and Heart (24.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MST1R Gene



Protein tissue co-expression partners for MST1R Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MST1R

SOURCE GeneReport for Unigene cluster for MST1R Gene:

Hs.517973

mRNA Expression by UniProt/SwissProt for MST1R Gene:

Q04912-RON_HUMAN
Tissue specificity: Expressed in colon, skin, lung and bone marrow.

Evidence on tissue expression from TISSUES for MST1R Gene

  • Skin(4.6)
  • Intestine(2.6)
  • Stomach(2.5)
  • Blood(2.2)
  • Liver(2.1)
  • Lung(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with MST1R: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MST1R Gene

Orthologs for MST1R Gene

This gene was present in the common ancestor of animals.

Orthologs for MST1R Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MST1R 29 30
  • 99.55 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MST1R 29 30
  • 82.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MST1R 29 30
  • 82.54 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mst1r 29 16 30
  • 78.74 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mst1r 29
  • 78.29 (n)
Oppossum
(Monodelphis domestica)
Mammalia MST1R 30
  • 53 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MST1R 30
  • 50 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MST1R 29 30
  • 58.92 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MST1R 30
  • 39 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100496572 29
  • 52.33 (n)
Zebrafish
(Danio rerio)
Actinopterygii mst1rb 29 30
  • 49.59 (n)
OneToMany
mst1ra 30
  • 39 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta hop 31
  • 37 (a)
Worm
(Caenorhabditis elegans)
Secernentea F11E6.8 31
  • 49 (a)
T14E8.1b 31
  • 40 (a)
T14E8.1a 31
  • 36 (a)
W04G5.10 31
  • 34 (a)
F09A5.2 31
  • 33 (a)
kin-23 31
  • 33 (a)
old-2 31
  • 32 (a)
kin-16 31
  • 31 (a)
old-1 31
  • 30 (a)
svh-2 30
  • 20 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 44 (a)
OneToMany
Species where no ortholog for MST1R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MST1R Gene

ENSEMBL:
Gene Tree for MST1R (if available)
TreeFam:
Gene Tree for MST1R (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MST1R: view image
Alliance of Genome Resources:
Additional Orthologs for MST1R

Paralogs for MST1R Gene

genes like me logo Genes that share paralogs with MST1R: view

Variants for MST1R Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MST1R Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs13318943 Benign: not provided 49,903,066(-) A/G
NM_002447.4(MST1R):c.544T>C (p.Leu182=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs1575446356 Likely Pathogenic: Multiple myeloma 49,898,938(-) C/A
NM_002447.4(MST1R):c.1477G>T (p.Asp493Tyr)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON
rs200046052 Risk Factor: Nasopharyngeal carcinoma, susceptibility to, 3. Nasopharyngeal carcinoma, 3 (NPCA3) [MIM:617075] 49,902,693(-) C/Tp.Arg306His
NM_002447.4(MST1R):c.917G>A (p.Arg306His)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs200757776 Nasopharyngeal carcinoma, 3 (NPCA3) [MIM:617075] p.Ala327Thr
rs201024956 Nasopharyngeal carcinoma, 3 (NPCA3) [MIM:617075] p.Val670Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MST1R Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MST1R Gene

Variant ID Type Subtype PubMed ID
dgv890e214 CNV loss 21293372
esv3596133 CNV gain 21293372
nsv1074591 CNV deletion 25765185
nsv834688 CNV loss 17160897

Variation tolerance for MST1R Gene

Residual Variation Intolerance Score: 4.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MST1R Gene

Human Gene Mutation Database (HGMD)
MST1R
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MST1R
Leiden Open Variation Database (LOVD)
MST1R

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MST1R Gene

Disorders for MST1R Gene

MalaCards: The human disease database

(17) MalaCards diseases for MST1R Gene - From: OMI, CVR, SWI, COP, and GCD

Disorder Aliases PubMed IDs
nasopharyngeal carcinoma 3
  • nasopharyngeal carcinoma, susceptibility to, 3
nasopharyngeal carcinoma
  • npca
gastroesophageal adenocarcinoma
  • gastric and esophageal adenocarcinoma
myeloma, multiple
  • multiple myeloma, susceptibility to
plasma cell neoplasm
  • plasma cell dyscrasia
- elite association - COSMIC cancer census association via MalaCards
Search MST1R in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RON_HUMAN
  • Nasopharyngeal carcinoma, 3 (NPCA3) [MIM:617075]: A form of nasopharyngeal carcinoma, a malignant neoplasm that originates in the nasopharyngeal epithelium and includes 4 subtypes: keratinizing squamous cell, non-keratinizing, basaloid squamous cell, and papillary adenocarcinoma. {ECO:0000269 PubMed:26951679}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Additional Disease Information for MST1R

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MST1R: view

No data available for Genatlas for MST1R Gene

Publications for MST1R Gene

  1. A novel putative receptor protein tyrosine kinase of the met family. (PMID: 8386824) Ronsin C … Breathnach R (Oncogene 1993) 2 3 4 22
  2. Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma. (PMID: 26951679) Dai W … Lung ML (Proceedings of the National Academy of Sciences of the United States of America 2016) 3 4 72
  3. Interplay between scatter factor receptors and B plexins controls invasive growth. (PMID: 15184888) Conrotto P … Giordano S (Oncogene 2004) 3 4 22
  4. c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. (PMID: 12802274) Penengo L … Gaudino G (Oncogene 2003) 3 4 22
  5. Identification of the ron gene product as the receptor for the human macrophage stimulating protein. (PMID: 7939629) Wang MH … Breathnach R (Science (New York, N.Y.) 1994) 3 4 22

Products for MST1R Gene

Sources for MST1R Gene