The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial l... See more...

Aliases for MST1 Gene

Aliases for MST1 Gene

  • Macrophage Stimulating 1 2 3 5
  • MSP 2 3 4
  • Hepatocyte Growth Factor-Like Protein 3 4
  • Macrophage-Stimulating Protein 3 4
  • D3F15S2 3 4
  • DNF15S2 3 4
  • NF15S2 2 3
  • HGFL 3 4
  • Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) 3
  • Hepatocyte Growth Factor-Like Protein Homolog 3
  • Macrophage Stimulatory Protein 4
  • Hepatocyte Growth Factor-Like 2
  • EC 3.4.21 51
  • MST1 5

External Ids for MST1 Gene

Previous HGNC Symbols for MST1 Gene

  • D3F15S2
  • HGFL
  • DNF15S2

Previous GeneCards Identifiers for MST1 Gene

  • GC03P046385
  • GC03P048678
  • GC03M049575
  • GC03M049681
  • GC03M049696
  • GC03M049730

Summaries for MST1 Gene

Entrez Gene Summary for MST1 Gene

  • The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]

GeneCards Summary for MST1 Gene

MST1 (Macrophage Stimulating 1) is a Protein Coding gene. Diseases associated with MST1 include Cholangitis, Primary Sclerosing and Inflammatory Bowel Disease 12. Among its related pathways are Signaling by GPCR and amb2 Integrin signaling. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is HGF.

Gene Wiki entry for MST1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MST1 Gene

Genomics for MST1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MST1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MST1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MST1

Top Transcription factor binding sites by QIAGEN in the MST1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • SEF-1 (1)

Genomic Locations for MST1 Gene

Genomic Locations for MST1 Gene
chr3:49,683,947-49,689,523
(GRCh38/hg38)
Size:
5,577 bases
Orientation:
Minus strand
chr3:49,721,380-49,726,934
(GRCh37/hg19)
Size:
5,555 bases
Orientation:
Minus strand

Genomic View for MST1 Gene

Genes around MST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MST1 Gene

Proteins for MST1 Gene

  • Protein details for MST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26927-HGFL_HUMAN
    Recommended name:
    Hepatocyte growth factor-like protein
    Protein Accession:
    P26927
    Secondary Accessions:
    • A6NLA3
    • A8MSX3
    • Q13350
    • Q14870
    • Q6GTN4

    Protein attributes for MST1 Gene

    Size:
    711 amino acids
    Molecular mass:
    80320 Da
    Quaternary structure:
    • Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts (via beta chain) with MST1R (via SEMA domain).

    Three dimensional structures from OCA and Proteopedia for MST1 Gene

neXtProt entry for MST1 Gene

Selected DME Specific Peptides for MST1 Gene

P26927:
  • CRNPDGD
  • PWCYTTDP
  • HFCGGSL
  • NYCRNPD

Post-translational modifications for MST1 Gene

  • Cleaved after Arg-483, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains.
  • Glycosylation at Asn72, Asn238, Asn296, and Asn615
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Domains & Families for MST1 Gene

Gene Families for MST1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MST1 Gene

InterPro:
Blocks:
  • Kringle
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
  • N/apple PAN
  • Apple-like
ProtoNet:

Suggested Antigen Peptide Sequences for MST1 Gene

GenScript: Design optimal peptide antigens:
  • Macrophage-stimulating protein (HGFL_HUMAN)
  • MST1 protein (Q49A61_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P26927

UniProtKB/Swiss-Prot:

HGFL_HUMAN :
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
Family:
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
genes like me logo Genes that share domains with MST1: view

Function for MST1 Gene

Molecular function for MST1 Gene

GENATLAS Biochemistry:
macrophage stimulating,protein 1,paralog to HGF

Enzyme Numbers (IUBMB) for MST1 Gene

Phenotypes From GWAS Catalog for MST1 Gene

Gene Ontology (GO) - Molecular Function for MST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 22087277
GO:0019899 enzyme binding IEA --
GO:0030971 receptor tyrosine kinase binding IDA 22087277
genes like me logo Genes that share ontologies with MST1: view
genes like me logo Genes that share phenotypes with MST1: view

Human Phenotype Ontology for MST1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MST1 Gene

MGI Knock Outs for MST1:
  • Mst1 Mst1<tm1Jab>
  • Mst1 Mst1<tm1(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for MST1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MST1

No data available for Transcription Factor Targets and HOMER Transcription for MST1 Gene

Localization for MST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MST1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MST1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for MST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 7508914
GO:0005737 cytoplasm IEA --
GO:0005773 vacuole IEA --
GO:0062023 collagen-containing extracellular matrix HDA 25037231
genes like me logo Genes that share ontologies with MST1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MST1 Gene

Pathways & Interactions for MST1 Gene

genes like me logo Genes that share pathways with MST1: view

Pathways by source for MST1 Gene

2 Reactome pathways for MST1 Gene
1 Qiagen pathway for MST1 Gene
  • MSP-RON Signaling
1 GeneTex pathway for MST1 Gene

SIGNOR curated interactions for MST1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007283 spermatogenesis IEA --
GO:0007566 embryo implantation IEA --
GO:0010628 positive regulation of gene expression IEA --
GO:0010758 regulation of macrophage chemotaxis IEA,IBA 21873635
genes like me logo Genes that share ontologies with MST1: view

Drugs & Compounds for MST1 Gene

(6) Drugs for MST1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for MST1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MST1: view

Transcripts for MST1 Gene

mRNA/cDNA for MST1 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MST1

Alternative Splicing Database (ASD) splice patterns (SP) for MST1 Gene

No ASD Table

Relevant External Links for MST1 Gene

GeneLoc Exon Structure for
MST1

Expression for MST1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MST1 Gene

mRNA differential expression in normal tissues according to GTEx for MST1 Gene

This gene is overexpressed in Liver (x31.7).

Protein differential expression in normal tissues from HIPED for MST1 Gene

This gene is overexpressed in Serum (36.4), Plasma (19.4), and Synovial fluid (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MST1 Gene



Protein tissue co-expression partners for MST1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MST1

SOURCE GeneReport for Unigene cluster for MST1 Gene:

Hs.349110

Evidence on tissue expression from TISSUES for MST1 Gene

  • Liver(5)
  • Bone marrow(4.4)
  • Nervous system(4.4)
  • Kidney(3.9)
  • Intestine(3.6)
  • Skin(2.5)
  • Heart(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MST1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • urinary
Regions:
Head and neck:
  • eye
  • head
  • mouth
Abdomen:
  • abdominal wall
  • biliary tract
  • gallbladder
  • kidney
  • liver
  • pancreas
Pelvis:
  • ureter
  • urinary bladder
General:
  • skin
genes like me logo Genes that share expression patterns with MST1: view

No data available for mRNA Expression by UniProt/SwissProt for MST1 Gene

Orthologs for MST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MST1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MST1 30 31
  • 99.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MST1 30 31
  • 86.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MST1 30 31
  • 81.97 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mst1 30 17 31
  • 81.4 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mst1 30
  • 80.83 (n)
Oppossum
(Monodelphis domestica)
Mammalia MST1 31
  • 68 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MST1 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MST1 30 31
  • 67.44 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MST1 31
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mst1 30
  • 61.72 (n)
Str.2230 30
African clawed frog
(Xenopus laevis)
Amphibia MGC54016 30
Zebrafish
(Danio rerio)
Actinopterygii mst1 30 31
  • 59.82 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10681 30
Fruit Fly
(Drosophila melanogaster)
Insecta Tequila 31
  • 5 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea svh-1 31
  • 14 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 20 (a)
OneToMany
Species where no ortholog for MST1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MST1 Gene

ENSEMBL:
Gene Tree for MST1 (if available)
TreeFam:
Gene Tree for MST1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MST1: view image

Paralogs for MST1 Gene

Paralogs for MST1 Gene

(33) SIMAP similar genes for MST1 Gene using alignment to 5 proteins:

  • HGFL_HUMAN
  • F5H6L8_HUMAN
  • G3XAK1_HUMAN
  • H7C0F8_HUMAN
  • Q49A61_HUMAN

Pseudogenes.org Pseudogenes for MST1 Gene

genes like me logo Genes that share paralogs with MST1: view

Variants for MST1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MST1 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
721569 Benign: not provided 49,685,273(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
769273 Likely Benign: not provided 49,686,351(-) C/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
769603 Likely Benign: not provided 49,686,390(-) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
783381 Benign: not provided 49,687,032(-) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs62262686 Uncertain Significance: not provided 49,688,637(-) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for MST1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MST1 Gene

Variant ID Type Subtype PubMed ID
esv28815 CNV gain+loss 19812545
nsv1118699 CNV duplication 24896259
nsv1141429 CNV duplication 24896259
nsv1148681 CNV duplication 26484159
nsv471425 CNV gain 19718026
nsv482080 CNV gain 20164927
nsv508217 CNV deletion 20534489
nsv820990 CNV duplication 20802225
nsv822077 CNV gain 20364138

Variation tolerance for MST1 Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.53; 82.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MST1 Gene

Human Gene Mutation Database (HGMD)
MST1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MST1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MST1 Gene

Disorders for MST1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MST1 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cholangitis, primary sclerosing
  • psc
inflammatory bowel disease 12
  • ibd12
sclerosing cholangitis
  • primary sclerosing cholangitis
inflammatory bowel disease
  • inflammatory bowel diseases
- elite association - COSMIC cancer census association via MalaCards
Search MST1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HGFL_HUMAN
  • Note=MST1 variant Cys-689 may be associated with inflammatory bowel disease (IBD), a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is unsure whether Cys-689 itself or a variation in linkage disequilibrium with Cys-689 is responsible for the association with IBD. {ECO:0000269 PubMed:19079170, ECO:0000269 PubMed:20228799}.

Additional Disease Information for MST1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MST1: view

No data available for Genatlas for MST1 Gene

Publications for MST1 Gene

  1. Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3. (PMID: 8393443) Yoshimura T … Leonard EJ (The Journal of biological chemistry 1993) 2 3 4 23
  2. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PMID: 20228799) McGovern DP … Seielstad M (Nature genetics 2010) 3 4 41
  3. Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. (PMID: 19079170) Goyette P … Rioux JD (Mucosal immunology 2008) 3 4 23
  4. Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity. (PMID: 1827141) Skeel A … Leonard EJ (The Journal of experimental medicine 1991) 3 4 23
  5. Proteolytic activation of pro-macrophage-stimulating protein by hepsin. (PMID: 21875933) Ganesan R … Kirchhofer D (Molecular cancer research : MCR 2011) 3 4

Products for MST1 Gene

Sources for MST1 Gene