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Aliases for MSS51 Gene

Aliases for MSS51 Gene

  • MSS51 Mitochondrial Translational Activator 2 3 5
  • Putative Protein MSS51 Homolog, Mitochondrial 3 4
  • Zinc Finger MYND Domain-Containing Protein 17 3 4
  • Zinc Finger, MYND-Type Containing 17 2 3
  • ZMYND17 3 4
  • MSS51 Mitochondrial Translational Activator Homolog (S. Cerevisiae) 2
  • MSS51 Mitochondrial Translational Activator Homolog 3
  • Zinc Finger, MYND Domain Containing 17 3

External Ids for MSS51 Gene

Previous HGNC Symbols for MSS51 Gene

  • ZMYND17

Previous GeneCards Identifiers for MSS51 Gene

  • GC10M075184

Summaries for MSS51 Gene

GeneCards Summary for MSS51 Gene

MSS51 (MSS51 Mitochondrial Translational Activator) is a Protein Coding gene. An important paralog of this gene is ZMYND10.

Additional gene information for MSS51 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSS51 Gene

Genomics for MSS51 Gene

GeneHancer (GH) Regulatory Elements for MSS51 Gene

Promoters and enhancers for MSS51 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J073433 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 600.7 +0.2 225 1.5 MSS51 CFAP70 GC10M073428
GH10J073437 Promoter 0.5 EPDnew 600.7 -4.4 -4448 0.1 MSS51 PPP3CB PPP3CB-AS1
GH10J073419 Enhancer 1.2 FANTOM5 Ensembl ENCODE 2.1 +14.0 13960 0.8 ZNF652 ZNF384 ZSCAN21 SMARCA4 CREB1 IKZF1 ZNF629 MTA2 ZNF316 JUN CFAP70 ENSG00000233144 RNU6-883P USP54 MSS51 GC10P073416 RPL26P6
GH10J073493 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 0.2 -61.7 -61741 3.5 SP1 ZFX ZNF148 NKRF MLLT1 ZNF121 POLR2A GTF2F1 CSDE1 ZNF687 PPP3CB-AS1 PPP3CB CFAP70 SEC24C ENSG00000272140 NDST2 ZSWIM8 AP3M1 GLUD1P3 DUSP8P5
GH10J073456 Enhancer 0.9 ENCODE 0.3 -22.8 -22817 0.1 CC2D1A ZKSCAN8 CBFA2T2 ZNF148 GTF2F1 CDC5L BACH1 NCOA6 TRIM24 EGR1 SYNPO2L USP54 RNU6-883P MSS51 PPP3CB-AS1 PPP3CB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MSS51 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MSS51 Gene

Genomic Locations for MSS51 Gene
chr10:73,423,579-73,433,561
(GRCh38/hg38)
Size:
9,983 bases
Orientation:
Minus strand
chr10:75,183,337-75,193,319
(GRCh37/hg19)
Size:
9,983 bases
Orientation:
Minus strand

Genomic View for MSS51 Gene

Genes around MSS51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSS51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSS51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSS51 Gene

Proteins for MSS51 Gene

  • Protein details for MSS51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VC12-MSS51_HUMAN
    Recommended name:
    Putative protein MSS51 homolog, mitochondrial
    Protein Accession:
    Q4VC12
    Secondary Accessions:
    • A6NGH6
    • Q2VP95
    • Q5F2H5
    • Q7Z3M9
    • Q8N8G0

    Protein attributes for MSS51 Gene

    Size:
    460 amino acids
    Molecular mass:
    51289 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MSS51 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSS51 Gene

Post-translational modifications for MSS51 Gene

No Post-translational modifications

Other Protein References for MSS51 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MSS51 Gene

Domains & Families for MSS51 Gene

Gene Families for MSS51 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MSS51 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MSS51 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger MYND domain-containing protein 17 (ZMY17_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MSS51: view

No data available for UniProtKB/Swiss-Prot for MSS51 Gene

Function for MSS51 Gene

Gene Ontology (GO) - Molecular Function for MSS51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MSS51: view
genes like me logo Genes that share phenotypes with MSS51: view

Animal Model Products

CRISPR Products

miRNA for MSS51 Gene

miRTarBase miRNAs that target MSS51

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MSS51

Clone Products

  • Applied Biological Materials (abm): Clones for MSS51 - Now 50% OFF >
  • * MSS51 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MSS51 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSS51 Gene

Localization for MSS51 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSS51 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Vesicles (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MSS51 Gene

Pathways & Interactions for MSS51 Gene

PathCards logo

SuperPathways for MSS51 Gene

No Data Available

Interacting Proteins for MSS51 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000299432%0d9606.ENSP00000361855%0d9606.ENSP00000361867%0d9606.ENSP00000344431%0d
Selected Interacting proteins: ENSP00000299432 for MSS51 Gene via STRING

Gene Ontology (GO) - Biological Process for MSS51 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MSS51 Gene

Drugs & Compounds for MSS51 Gene

No Compound Related Data Available

Transcripts for MSS51 Gene

mRNA/cDNA for MSS51 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for MSS51 Gene

MSS51 mitochondrial translational activator:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MSS51

Clone Products

  • Applied Biological Materials (abm): Clones for MSS51 - Now 50% OFF >
  • * MSS51 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MSS51 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for MSS51 Gene

No ASD Table

Relevant External Links for MSS51 Gene

GeneLoc Exon Structure for
MSS51
ECgene alternative splicing isoforms for
MSS51

Expression for MSS51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MSS51 Gene

mRNA differential expression in normal tissues according to GTEx for MSS51 Gene

This gene is overexpressed in Muscle - Skeletal (x18.4).

NURSA nuclear receptor signaling pathways regulating expression of MSS51 Gene:

MSS51

SOURCE GeneReport for Unigene cluster for MSS51 Gene:

Hs.631823

Evidence on tissue expression from TISSUES for MSS51 Gene

  • Muscle(4.4)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MSS51: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MSS51 Gene

Orthologs for MSS51 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSS51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMYND17 34
  • 99.2 (n)
MSS51 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSS51 35 34
  • 88.26 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZMYND17 34
  • 87.67 (n)
MSS51 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mss51 17 35 34
  • 84.35 (n)
rat
(Rattus norvegicus)
Mammalia Mss51 34
  • 81.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MSS51 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSS51 35 34
  • 61.37 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSS51 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496751 34
  • 57.39 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330275 34
  • 55.26 (n)
mss51 35
  • 48 (a)
OneToOne
Species where no ortholog for MSS51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSS51 Gene

ENSEMBL:
Gene Tree for MSS51 (if available)
TreeFam:
Gene Tree for MSS51 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MSS51: view image

Paralogs for MSS51 Gene

Paralogs for MSS51 Gene

(1) SIMAP similar genes for MSS51 Gene using alignment to 2 proteins:

  • MSS51_HUMAN
  • F6VAV3_HUMAN
genes like me logo Genes that share paralogs with MSS51: view

Variants for MSS51 Gene

Sequence variations from dbSNP and Humsavar for MSS51 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000924322 -- 73,432,896(-) G/A intron_variant
rs1000935773 -- 73,429,230(-) A/G intron_variant
rs1001323310 -- 73,428,232(-) G/A coding_sequence_variant, missense_variant
rs1001679809 -- 73,434,802(-) C/T upstream_transcript_variant
rs1001832791 -- 73,432,089(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MSS51 Gene

Variant ID Type Subtype PubMed ID
nsv831911 CNV loss 17160897

Variation tolerance for MSS51 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MSS51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSS51
Human Gene Mutation Database (HGMD)
MSS51

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSS51 Gene

Disorders for MSS51 Gene

Additional Disease Information for MSS51

No disorders were found for MSS51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSS51 Gene

Publications for MSS51 Gene

  1. Dual functions of Mss51 couple synthesis of Cox1 to assembly of cytochrome c oxidase in Saccharomyces cerevisiae mitochondria. (PMID: 19710419) Perez-Martinez X … Fox TD (Molecular biology of the cell 2009) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58
  4. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function. (PMID: 21531385) Liu CM … Hwu HG (Biological psychiatry 2011) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for MSS51 Gene

Sources for MSS51 Gene

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