MSR1 Gene (Protein Coding)

Macrophage Scavenger Receptor 1

GC08M016107
GIFtS:
46
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheime... See more...

Aliases for MSR1 Gene

Aliases for MSR1 Gene

  • Macrophage Scavenger Receptor 1 2 3 5
  • SCARA1 2 3 4
  • Macrophage Scavenger Receptor Types I And II 3 4
  • Macrophage Acetylated LDL Receptor I And II 3 4
  • Scavenger Receptor Class A Member 1 3 4
  • SR-AIII 2 3
  • SR-AII 2 3
  • CD204 2 3
  • SR-AI 2 3
  • SR-A 2 3
  • Macrophage Scavenger Receptor Type III 3
  • CD204 Antigen 4
  • PhSR1 3
  • PhSR2 3
  • MSR1 5
  • SRA 3

External Ids for MSR1 Gene

Previous GeneCards Identifiers for MSR1 Gene

  • GC08M015739
  • GC08M015926
  • GC08M015975
  • GC08M016009
  • GC08M014509

Summaries for MSR1 Gene

Entrez Gene Summary for MSR1 Gene

  • This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

GeneCards Summary for MSR1 Gene

MSR1 (Macrophage Scavenger Receptor 1) is a Protein Coding gene. Diseases associated with MSR1 include Barrett Esophagus and Non-Alcoholic Fatty Liver Disease. Among its related pathways are A-beta Uptake and Degradation and Binding and Uptake of Ligands by Scavenger Receptors. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and scavenger receptor activity. An important paralog of this gene is SCARA5.

UniProtKB/Swiss-Prot Summary for MSR1 Gene

  • Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform III does not internalize acetylated LDL (PubMed:9548586).

Gene Wiki entry for MSR1 Gene

Additional gene information for MSR1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MSR1 Gene

Genomics for MSR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MSR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08J016192 Promoter 0.7 EPDnew Ensembl 605 +375.9 375889 3.2 MSR1 piR-48222-340 piR-35002-102 TUSC3
GH08J016566 Enhancer 0.5 Ensembl 614 -1.0 -1011 2.2 MGA NR2C2 GTF2A2 ZNF584 JUN L3MBTL2 MSR1 lnc-MSR1-2 lnc-MICU3-2 ENSG00000253184 LOC101929028 FGF20
GH08J016188 Promoter 0.3 EPDnew 600 +381.2 381198 0.1 MSR1 piR-48222-340 piR-35002-102 TUSC3
GH08J016603 Promoter/Enhancer 1 Ensembl ENCODE 21.2 -36.6 -36643 1.4 RXRB IRF2 SP1 SOX13 CEBPB MAFF NR2C2 GABPA YY1 ZNF205 ENSG00000253184 MSR1 lnc-MSR1-2 LOC101929028 ENSG00000253496 FGF20
GH08J016544 Enhancer 0.9 Ensembl dbSUPER 15.6 +22.4 22389 1 LEF1 SOX6 TCF12 EP300 ZBTB11 MNT MYC TRIM24 NCOR1 CEBPG MSR1 lnc-MICU3-2 lnc-MSR1-2 piR-32285-090 LOC101929028
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MSR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MSR1

Top Transcription factor binding sites by QIAGEN in the MSR1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • GATA-1

Genomic Locations for MSR1 Gene

Genomic Locations for MSR1 Gene
chr8:16,107,878-16,567,490
(GRCh38/hg38)
Size:
459,613 bases
Orientation:
Minus strand
chr8:15,965,387-16,424,999
(GRCh37/hg19)
Size:
459,613 bases
Orientation:
Minus strand

Genomic View for MSR1 Gene

Genes around MSR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSR1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MSR1 Gene

Proteins for MSR1 Gene

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  • Protein details for MSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21757-MSRE_HUMAN
    Recommended name:
    Macrophage scavenger receptor types I and II
    Protein Accession:
    P21757
    Secondary Accessions:
    • D3DSP3
    • O60505
    • P21759
    • Q45F10

    Protein attributes for MSR1 Gene

    Size:
    451 amino acids
    Molecular mass:
    49762 Da
    Quaternary structure:
    • Homotrimer (By similarity). Interacts with MYO18A (PubMed:25965346).
    Miscellaneous:
    • [Isoform II]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for MSR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSR1 Gene

Protein Expression for MSR1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MSR1 Gene

  • Glycosylation at Asn82, Asn102, Asn143, Asn184, Asn221, Asn249, and Asn267
  • Modification sites at PhosphoSitePlus

Other Protein References for MSR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MSR1 Gene

Domains & Families for MSR1 Gene

Gene Families for MSR1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MSR1 Gene

InterPro:
Blocks:
  • Collagen triple helix repeat
  • Collagen helix repeat
  • Speract/scavenger receptor
  • Macrophage scavenger receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for MSR1 Gene

GenScript: Design optimal peptide antigens:
  • Scavenger receptor class A member 1 (MSRE_HUMAN)
genes like me logo Genes that share domains with MSR1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MSR1 Gene

Function for MSR1 Gene

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Molecular function for MSR1 Gene

UniProtKB/Swiss-Prot Function:
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform III does not internalize acetylated LDL (PubMed:9548586).
GENATLAS Biochemistry:
macrophage scavenger receptor 1 (oxidized low density lipoprotein receptor)

Phenotypes From GWAS Catalog for MSR1 Gene

Gene Ontology (GO) - Molecular Function for MSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding IBA,ISS --
GO:0005044 scavenger receptor activity TAS 11240025
GO:0005515 protein binding IPI 17237231
GO:0030169 low-density lipoprotein particle binding IBA,ISS 12376530
GO:0038024 cargo receptor activity ISS --
genes like me logo Genes that share ontologies with MSR1: view
genes like me logo Genes that share phenotypes with MSR1: view

Human Phenotype Ontology for MSR1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MSR1 Gene

MGI Knock Outs for MSR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MSR1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MSR1 Gene

Localization for MSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSR1 Gene

Membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSR1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8093617
GO:0009897 external side of plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with MSR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MSR1 Gene

Pathways & Interactions for MSR1 Gene

genes like me logo Genes that share pathways with MSR1: view

Pathways by source for MSR1 Gene

1 BioSystems pathway for MSR1 Gene
1 KEGG pathway for MSR1 Gene
1 R&D Systems pathway for MSR1 Gene
2 Qiagen pathways for MSR1 Gene
  • LDL Oxidation in Atherogenesis
  • Phagocytosis of Microbes

SIGNOR curated interactions for MSR1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis NAS,TAS --
GO:0006911 phagocytosis, engulfment ISS --
GO:0010629 negative regulation of gene expression ISS --
GO:0010744 positive regulation of macrophage derived foam cell differentiation ISS 12376530
genes like me logo Genes that share ontologies with MSR1: view

Drugs & Compounds for MSR1 Gene

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(9) Drugs for MSR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(9) Additional Compounds for MSR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MSR1: view

Transcripts for MSR1 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MSR1 Gene

4 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MSR1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2:
SP3: - -
SP4:

Relevant External Links for MSR1 Gene

GeneLoc Exon Structure for
MSR1

Expression for MSR1 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MSR1 Gene

mRNA expression in normal human tissues for MSR1 Gene
mRNA expression by GTEx for MSR1 GenemRNA expression by BioGPS for MSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSR1 Gene

This gene is overexpressed in Lung (x7.1).

Protein differential expression in normal tissues from HIPED for MSR1 Gene

This gene is overexpressed in Pancreas (48.3) and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MSR1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MSR1

SOURCE GeneReport for Unigene cluster for MSR1 Gene:

Hs.147635

mRNA Expression by UniProt/SwissProt for MSR1 Gene:

P21757-MSRE_HUMAN
Tissue specificity: Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. Isoform I and isoform II are expressed in the liver, placenta and brain.

Evidence on tissue expression from TISSUES for MSR1 Gene

  • Liver(4.5)
  • Spleen(2.9)
  • Lung(2.8)
  • Heart(2.8)
  • Lymph node(2.6)
  • Blood(2.6)
  • Bone marrow(2.5)
  • Nervous system(2.4)
  • Intestine(2.4)
  • Muscle(2.2)
  • Kidney(2.1)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MSR1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • nervous
  • reproductive
Regions:
Head and neck:
  • brain
  • cerebellum
  • head
Thorax:
  • esophagus
Abdomen:
  • stomach
Pelvis:
  • prostate
General:
  • spinal cord
genes like me logo Genes that share expression patterns with MSR1: view

No data available for Protein tissue co-expression partners for MSR1 Gene

Orthologs for MSR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MSR1 30 31
  • 99.31 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MSR1 30 31
  • 86.33 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MSR1 30 31
  • 81.07 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Msr1 30 17 31
  • 78 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Msr1 30
  • 77.58 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia MSR1 31
  • 49 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MSR1 31
  • 48 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia msr1 30
  • 53.95 (n)
Zebrafish
(Danio rerio)
 Actinopterygii CABZ01112729.1 31
  • 12 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 20 (a)
 OneToMany
Species where no ortholog for MSR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MSR1 Gene

ENSEMBL:
Gene Tree for MSR1 (if available)
TreeFam:
Gene Tree for MSR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MSR1: view image

Paralogs for MSR1 Gene

Paralogs for MSR1 Gene

(15) SIMAP similar genes for MSR1 Gene using alignment to 7 proteins:

  • MSRE_HUMAN
  • B4DDJ5_HUMAN
  • E5RFI4_HUMAN
  • E5RFW8_HUMAN
  • E5RI91_HUMAN
  • F5GZJ2_HUMAN
  • H0YBY2_HUMAN
genes like me logo Genes that share paralogs with MSR1: view

Variants for MSR1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MSR1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
712059 Benign: not provided 16,120,446(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
714374 Benign: not provided 16,143,548(-) A/G INTRON_VARIANT
714511 Benign: not provided 16,143,577(-) C/T SYNONYMOUS_VARIANT
729324 Benign: not provided 16,168,546(-) A/T MISSENSE_VARIANT
746739 Likely Benign: not provided 16,120,614(-) G/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MSR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MSR1 Gene

Variant ID Type Subtype PubMed ID
dgv12022n54 CNV loss 21841781
dgv12023n54 CNV loss 21841781
dgv12024n54 CNV loss 21841781
dgv12025n54 CNV loss 21841781
dgv1382e214 CNV loss 21293372
dgv2050e212 CNV loss 25503493
dgv249e55 CNV loss 17911159
dgv7109n100 CNV loss 25217958
dgv877n27 CNV loss 19166990
esv2668117 CNV deletion 23128226
esv2736661 CNV deletion 23290073
esv2736663 CNV deletion 23290073
esv2736664 CNV deletion 23290073
esv2764093 CNV gain+loss 21179565
esv3305201 CNV mobile element insertion 20981092
esv3391592 CNV insertion 20981092
esv3448 CNV loss 18987735
esv3543130 CNV deletion 23714750
esv3543133 CNV deletion 23714750
esv3572568 CNV loss 25503493
esv3572569 CNV loss 25503493
esv3572572 CNV loss 25503493
esv3576529 CNV gain 25503493
esv3616422 CNV loss 21293372
esv3616423 CNV gain 21293372
esv3616424 CNV gain 21293372
esv3616432 CNV gain 21293372
esv3616433 CNV loss 21293372
esv3891356 CNV loss 25118596
nsv1020762 CNV gain 25217958
nsv1021412 CNV loss 25217958
nsv1023558 CNV gain 25217958
nsv1024623 CNV gain 25217958
nsv1028894 CNV loss 25217958
nsv1029399 CNV gain 25217958
nsv1031894 CNV gain 25217958
nsv1075117 CNV deletion 25765185
nsv1117810 CNV deletion 24896259
nsv1120558 CNV tandem duplication 24896259
nsv1124325 CNV deletion 24896259
nsv1128403 CNV deletion 24896259
nsv1128404 CNV deletion 24896259
nsv1143207 CNV tandem duplication 24896259
nsv465581 CNV loss 19166990
nsv465582 CNV loss 19166990
nsv470195 CNV loss 18288195
nsv472653 CNV novel sequence insertion 20440878
nsv512943 CNV insertion 21212237
nsv516531 CNV loss 19592680
nsv519153 CNV loss 19592680
nsv520688 CNV loss 19592680
nsv610576 CNV gain 21841781
nsv610590 CNV loss 21841781
nsv610594 CNV loss 21841781
nsv610599 CNV loss 21841781
nsv824552 CNV loss 20364138
nsv831241 CNV gain+loss 17160897

Variation tolerance for MSR1 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.97; 89.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MSR1 Gene

Human Gene Mutation Database (HGMD)
MSR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSR1 Gene

Disorders for MSR1 Gene

MalaCards: The human disease database

(15) MalaCards diseases for MSR1 Gene - From: LncRNADisease, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
barrett esophagus
  • barrett metaplasia
non-alcoholic fatty liver disease
  • nafld
polycystic ovary syndrome
  • pco
breast cancer
  • breast lobular carcinoma
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search MSR1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MSRE_HUMAN
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:12244320}. Note=The disease may be caused by mutations affecting the gene represented in this entry. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families.
  • Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. {ECO:0000269 PubMed:21791690}. Note=The disease may be caused by mutations affecting the gene represented in this entry. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility.

Additional Disease Information for MSR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MSR1: view

No data available for Genatlas for MSR1 Gene

Publications for MSR1 Gene

  1. Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. (PMID: 12244320) Xu J … Meyers DA (Nature genetics 2002) 3 4 23 41
  2. Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men. (PMID: 20086112) Beuten J … Leach RJ (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 23 41
  3. COPD is associated with a macrophage scavenger receptor-1 gene sequence variation. (PMID: 20081102) Ohar JA … Holian A (Chest 2010) 3 23 41
  4. Increased risk for atherosclerosis of various macrophage scavenger receptor 1 alleles. (PMID: 19715475) Durst R … Lotan C (Genetic testing and molecular biomarkers 2009) 3 23 41
  5. Analysis of the RNASEL/HPC1, and macrophage scavenger receptor 1 in Asian-Indian advanced prostate cancer. (PMID: 18436282) Rennert H … Rebbeck TR (Urology 2008) 3 23 41

ExternalLinks

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