The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein ... See more...

Aliases for MSMB Gene

Aliases for MSMB Gene

  • Microseminoprotein Beta 2 3 5
  • Beta-Microseminoprotein 2 3 4
  • PSP-94 2 3 4
  • PSP94 2 3 4
  • IGBF 2 3 4
  • PN44 2 3 4
  • Prostate Secretory Protein Of 94 Amino Acids 3 4
  • Prostate Secreted Seminal Plasma Protein 3 4
  • Seminal Plasma Beta-Inhibin 3 4
  • PSP57 2 3
  • MSPB 2 3
  • PRPS 2 3
  • MSP 2 3
  • PSP 2 3
  • Immunoglobulin Binding Factor 3
  • Immunoglobulin-Binding Factor 4
  • Microseminoprotein, Beta- 2
  • HPC13 3
  • MSMB 5
  • PRSP 4

External Ids for MSMB Gene

Previous GeneCards Identifiers for MSMB Gene

  • GC10P050393
  • GC10P051441
  • GC10P050894
  • GC10P051219
  • GC10P051549
  • GC10P045657

Summaries for MSMB Gene

Entrez Gene Summary for MSMB Gene

  • The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MSMB Gene

MSMB (Microseminoprotein Beta) is a Protein Coding gene. Diseases associated with MSMB include Prostate Cancer, Hereditary, 13 and Creutzfeldt-Jakob Disease. An important paralog of this gene is MSMP.

Gene Wiki entry for MSMB Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MSMB Gene

Genomics for MSMB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MSMB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J046091 Promoter/Enhancer 1.7 EPDnew FANTOM5 ENCODE CraniofacialAtlas dbSUPER 625.1 -46.6 -46585 7.3 HNRNPL GATAD2A TFE3 ZIC2 PKNOX1 RXRB IRF2 IKZF2 GABPA ZNF311 MSMB NCOA4 AGAP7P PARGP1 WASHC2C BMS1P1 SHLD2P1 TIMM23 piR-43107-037 piR-57455
GH10J046048 Enhancer 0.7 ENCODE 600.7 -0.1 -147 0.2 CREB1 GATAD2A RCOR2 RXRB ATF7 SOX13 ESR1 CTBP1 ESRRA ZNF217 MSMB piR-50517-001 ANTXRL
GH10J046049 Enhancer 0.7 ENCODE 613 -0.3 -327 0.2 CREB1 GATAD2A RCOR2 RXRB ATF7 ESR1 CTBP1 ESRRA PKNOX1 ZNF217 MSMB piR-50517-001 ANTXRL
GH10J046046 Promoter 0.3 EPDnew 600.7 +1.9 1891 0.1 MSMB lnc-MSMB-1-001 NCOA4
GH10J046076 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 27 -30.7 -30721 6.6 GATAD2A ARID3A FOXA1 PKNOX1 MTA1 HDAC1 CEBPA EP300 SOX13 CEBPB MSMB AGAP7P NCOA4 RF00017-660 piR-60985-014 ANTXRL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MSMB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MSMB

Top Transcription factor binding sites by QIAGEN in the MSMB gene promoter:
  • AP-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for MSMB Gene

Genomic Locations for MSMB Gene
chr10:46,033,305-46,048,180
(GRCh38/hg38)
Size:
14,876 bases
Orientation:
Minus strand
chr10:51,549,498-51,562,517
(GRCh37/hg19)
Size:
13,020 bases
Orientation:
Plus strand

Genomic View for MSMB Gene

Genes around MSMB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSMB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSMB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSMB Gene

Proteins for MSMB Gene

  • Protein details for MSMB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08118-MSMB_HUMAN
    Recommended name:
    Beta-microseminoprotein
    Protein Accession:
    P08118
    Secondary Accessions:
    • B1API6
    • P11999
    • Q13125
    • Q6IAY9
    • Q9UC59

    Protein attributes for MSMB Gene

    Size:
    114 amino acids
    Molecular mass:
    12865 Da
    Quaternary structure:
    • Homodimer; Interacts with PI16.
    Miscellaneous:
    • Specific receptors for this protein are found on spermatozoa and in the prostate.

    Three dimensional structures from OCA and Proteopedia for MSMB Gene

    Alternative splice isoforms for MSMB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSMB Gene

Post-translational modifications for MSMB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MSMB Gene

Antibody Products

No data available for DME Specific Peptides for MSMB Gene

Domains & Families for MSMB Gene

Gene Families for MSMB Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted secreted proteins

Protein Domains for MSMB Gene

InterPro:
Blocks:
  • Beta-microseminoprotein
ProtoNet:

Suggested Antigen Peptide Sequences for MSMB Gene

GenScript: Design optimal peptide antigens:
  • Seminal plasma beta-inhibin (MSMB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08118

UniProtKB/Swiss-Prot:

MSMB_HUMAN :
  • Belongs to the beta-microseminoprotein family.
Family:
  • Belongs to the beta-microseminoprotein family.
genes like me logo Genes that share domains with MSMB: view

Function for MSMB Gene

Molecular function for MSMB Gene

GENATLAS Biochemistry:
microseminoprotein beta,14kDa,synthesized by prostate epithelial cells,secreted in to the seminal fluid

Phenotypes From GWAS Catalog for MSMB Gene

Gene Ontology (GO) - Molecular Function for MSMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MSMB: view
genes like me logo Genes that share phenotypes with MSMB: view

Animal Models for MSMB Gene

MGI Knock Outs for MSMB:
  • Msmb Msmb<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for MSMB

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MSMB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MSMB Gene

Localization for MSMB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSMB Gene

Secreted. Note=Sperm surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSMB gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
golgi apparatus 2
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for MSMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 7566962
GO:0005634 nucleus TAS 7566962
genes like me logo Genes that share ontologies with MSMB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MSMB Gene

Pathways & Interactions for MSMB Gene

PathCards logo

SuperPathways for MSMB Gene

No Data Available

Interacting Proteins for MSMB Gene

Gene Ontology (GO) - Biological Process for MSMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MSMB: view

No data available for Pathways by source and SIGNOR curated interactions for MSMB Gene

Drugs & Compounds for MSMB Gene

(5) Drugs for MSMB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for MSMB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MSMB: view

Transcripts for MSMB Gene

mRNA/cDNA for MSMB Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MSMB

Alternative Splicing Database (ASD) splice patterns (SP) for MSMB Gene

No ASD Table

Relevant External Links for MSMB Gene

GeneLoc Exon Structure for
MSMB

Expression for MSMB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MSMB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSMB Gene

This gene is overexpressed in Prostate (x50.7).

Protein differential expression in normal tissues from HIPED for MSMB Gene

This gene is overexpressed in Urine (54.8) and Prostate (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MSMB Gene



Protein tissue co-expression partners for MSMB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MSMB

SOURCE GeneReport for Unigene cluster for MSMB Gene:

Hs.255462

mRNA Expression by UniProt/SwissProt for MSMB Gene:

P08118-MSMB_HUMAN
Tissue specificity: Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder.

Evidence on tissue expression from TISSUES for MSMB Gene

  • Muscle(3.2)
  • Lung(3.2)
  • Stomach(3.1)
  • Saliva(2.6)
  • Skin(2.5)
  • Nervous system(2.3)
  • Blood(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MSMB Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • reproductive
Regions:
Head and neck:
  • brain
  • cerebellum
  • head
Pelvis:
  • prostate
General:
  • spinal cord
genes like me logo Genes that share expression patterns with MSMB: view

Orthologs for MSMB Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MSMB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MSMB 30
  • 99.12 (n)
Rat
(Rattus norvegicus)
Mammalia Msmb 30
  • 62.24 (n)
Mouse
(Mus musculus)
Mammalia Msmb 30 17
  • 58.11 (n)
Species where no ortholog for MSMB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MSMB Gene

ENSEMBL:
Gene Tree for MSMB (if available)
TreeFam:
Gene Tree for MSMB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MSMB: view image

Paralogs for MSMB Gene

Paralogs for MSMB Gene

genes like me logo Genes that share paralogs with MSMB: view

Variants for MSMB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MSMB Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs10993994 Risk Factor: Prostate cancer, hereditary, 13 46,046,326(-) A/.
rs1802771 - p.Ile87Thr
rs1802774 - p.Asp80Ala
rs1804461 - p.Asp92Gly
rs1804464 - p.Val98Leu

Additional dbSNP identifiers (rs#s) for MSMB Gene

Structural Variations from Database of Genomic Variants (DGV) for MSMB Gene

Variant ID Type Subtype PubMed ID
esv3577172 CNV gain 25503493
esv3623185 CNV gain 21293372
nsv1041519 CNV gain 25217958
nsv1042912 CNV loss 25217958
nsv467192 CNV gain 19166990
nsv470936 CNV gain 18288195
nsv508583 CNV deletion 20534489
nsv510992 OTHER complex 20534489
nsv521269 CNV gain 19592680
nsv550853 CNV gain 21841781
nsv6643 CNV insertion 18451855

Variation tolerance for MSMB Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MSMB Gene

Human Gene Mutation Database (HGMD)
MSMB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSMB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSMB Gene

Disorders for MSMB Gene

MalaCards: The human disease database

(16) MalaCards diseases for MSMB Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer, hereditary, 13
  • hpc13
creutzfeldt-jakob disease
  • cjd
prion disease
  • prion disease pathway
prostate cancer
  • prostate cancer, somatic
scrapie
- elite association - COSMIC cancer census association via MalaCards
Search MSMB in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MSMB_HUMAN
  • Prostate cancer, hereditary, 13 (HPC13) [MIM:611928]: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for MSMB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MSMB: view

No data available for Genatlas for MSMB Gene

Publications for MSMB Gene

  1. Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer. (PMID: 20184897) Kumar A … Kumar M (Journal of molecular biology 2010) 3 4 23
  2. Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. (PMID: 19383797) Lou H … Chanock SJ (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 23 41
  3. Multiple loci identified in a genome-wide association study of prostate cancer. (PMID: 18264096) Thomas G … Chanock SJ (Nature genetics 2008) 3 4 41
  4. Solution structures of human and porcine beta-microseminoprotein. (PMID: 16930619) Ghasriani H … Drakenberg T (Journal of molecular biology 2006) 3 4 23
  5. Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. (PMID: 15344909) Reeves JR … Tanner JE (The Biochemical journal 2005) 3 4 23

Products for MSMB Gene

Sources for MSMB Gene