Aliases for MSLNL Gene

Aliases for MSLNL Gene

  • Mesothelin Like 2 3 5
  • Pre-Pro-Megakaryocyte-Potentiating-Factor-Like 3 4
  • C16orf37 3 4
  • MPFL 3 4
  • Chromosome 16 Open Reading Frame 37 2
  • Mesothelin-Like Protein 4
  • MPF-Like 3

External Ids for MSLNL Gene

Previous HGNC Symbols for MSLNL Gene

  • C16orf37

Previous GeneCards Identifiers for MSLNL Gene

  • GC16M000766
  • GC16M000819
  • GC16M000741
  • GC16M000799
  • GC16M000821
  • GC16M000997
  • GC16M001015
  • GC16M001030
  • GC16M000840
  • GC16M000865
  • GC16M000884
  • GC16M000900
  • GC16M000920
  • GC16M000938
  • GC16M000959
  • GC16M000978

Summaries for MSLNL Gene

GeneCards Summary for MSLNL Gene

MSLNL (Mesothelin Like) is a Pseudogene. An important paralog of this gene is MSLN.

UniProtKB/Swiss-Prot Summary for MSLNL Gene

Additional gene information for MSLNL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MSLNL Gene

Genomics for MSLNL Gene

GeneHancer (GH) Regulatory Elements for MSLNL Gene

Promoters and enhancers for MSLNL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J000783 Enhancer 0.7 Ensembl 500.7 -0.1 -131 1.8 ZIC2 POLR2A KDM5B NFIC NCOR1 MAX POLR2G ZFHX2 TAL1 MNT MSLNL MSLN PTX4 CHTF18
GH16J000769 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 11.6 +14.3 14269 1.8 GABPA YY1 KLF13 ZFHX2 SAFB MAZ SCRT1 HIC1 EGR1 VEZF1 5EW4_A-017 ENSG00000279136 MIR662 lnc-MSLNL-1 MSLN MSLNL ENSG00000261505 SNRNP25 CAPN15 NONHSAG018213.2
GH16J000787 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 5.3 -4.9 -4944 3.4 HNRNPK EP300 SIN3A NRF1 POLR2G SP1 PHF8 ZFX ZNF639 ZNF10 CHTF18 RPUSD1 NME3 LUC7L ENSG00000260646 ENSG00000228779 MSLN IFT140 MSLNL CIAO3
GH16J000785 Enhancer 0.8 ENCODE 0.7 -2.4 -2366 0.2 CTCF GABPA ZBTB26 REST MYC RAD21 CTBP1 TRIM22 SMC3 ZNF341 RPUSD1 CHTF18 MSLNL
GH16J000778 Enhancer 0.4 Ensembl 0.4 +5.4 5369 0.4 EZH2 ZNF18 IKZF1 POLR2A MSLN SNRNP25 MIR662 MSLNL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MSLNL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MSLNL gene promoter:
  • CBF(2)
  • E47
  • Elk-1
  • MyoD
  • NF-Y
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • Spz1

Genomic Locations for MSLNL Gene

Genomic Locations for MSLNL Gene
chr16:769,428-783,370
(GRCh38/hg38)
Size:
13,943 bases
Orientation:
Minus strand
chr16:819,428-833,370
(GRCh37/hg19)
Size:
13,943 bases
Orientation:
Minus strand

Genomic View for MSLNL Gene

Genes around MSLNL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSLNL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSLNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSLNL Gene

Proteins for MSLNL Gene

  • Protein details for MSLNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KJ4-MSLNL_HUMAN
    Recommended name:
    Mesothelin-like protein
    Protein Accession:
    Q96KJ4

    Protein attributes for MSLNL Gene

    Size:
    702 amino acids
    Molecular mass:
    74540 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK61254.1; Type=Erroneous gene model prediction; Note=The sequence shown is based on gene prediction by similarity with the mouse ortholog.; Evidence={ECO:0000305}; Sequence=EAW85717.1; Type=Erroneous gene model prediction; Note=The sequence shown is based on gene prediction by similarity with the mouse ortholog.; Evidence={ECO:0000305};

neXtProt entry for MSLNL Gene

Post-translational modifications for MSLNL Gene

  • Glycosylation at Asn122, Asn307, and Asn424
  • Modification sites at PhosphoSitePlus

Other Protein References for MSLNL Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MSLNL Gene

Domains & Families for MSLNL Gene

Gene Families for MSLNL Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MSLNL Gene

Suggested Antigen Peptide Sequences for MSLNL Gene

GenScript: Design optimal peptide antigens:
  • Pre-pro-megakaryocyte-potentiating-factor-like (MSLNL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96KJ4

UniProtKB/Swiss-Prot:

MSLNL_HUMAN :
  • Belongs to the mesothelin family.
Family:
  • Belongs to the mesothelin family.
genes like me logo Genes that share domains with MSLNL: view

Function for MSLNL Gene

Molecular function for MSLNL Gene

UniProtKB/Swiss-Prot Function:
May play a role in cellular adhesion.

Phenotypes From GWAS Catalog for MSLNL Gene

Phenotypes for MSLNL Gene

genes like me logo Genes that share phenotypes with MSLNL: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MSLNL Gene

Localization for MSLNL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSLNL Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSLNL gene
Compartment Confidence
plasma membrane 1
nucleus 1
cytosol 1
extracellular 0
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for MSLNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MSLNL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MSLNL Gene

Pathways & Interactions for MSLNL Gene

PathCards logo

SuperPathways for MSLNL Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MSLNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion IBA 21873635
genes like me logo Genes that share ontologies with MSLNL: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MSLNL Gene

Drugs & Compounds for MSLNL Gene

No Compound Related Data Available

Transcripts for MSLNL Gene

mRNA/cDNA for MSLNL Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSLNL Gene

No ASD Table

Relevant External Links for MSLNL Gene

GeneLoc Exon Structure for
MSLNL

Expression for MSLNL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MSLNL Gene

mRNA differential expression in normal tissues according to GTEx for MSLNL Gene

This gene is overexpressed in Brain - Cortex (x7.1), Lung (x5.0), Fallopian Tube (x4.8), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Putamen (basal ganglia) (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MSLNL

Evidence on tissue expression from TISSUES for MSLNL Gene

  • Bone(2.5)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with MSLNL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MSLNL Gene

Orthologs for MSLNL Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSLNL Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MSLNL 31
  • 69 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MSLNL 31
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mslnl 31
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MSLNL 31
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSLNL 31
  • 20 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSLNL 31
  • 38 (a)
OneToOne
Species where no ortholog for MSLNL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MSLNL Gene

ENSEMBL:
Gene Tree for MSLNL (if available)
TreeFam:
Gene Tree for MSLNL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MSLNL: view image

Paralogs for MSLNL Gene

Paralogs for MSLNL Gene

genes like me logo Genes that share paralogs with MSLNL: view

Variants for MSLNL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MSLNL Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs12599363 - p.Asp463Val
rs9746539 - p.Ser597Gly

Variation tolerance for MSLNL Gene

Gene Damage Index Score: 19.80; 98.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MSLNL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSLNL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Additional dbSNP identifiers (rs#s) and Structural Variations from Database of Genomic Variants (DGV) for MSLNL Gene

Disorders for MSLNL Gene

No disorders were found for MSLNL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for MSLNL Gene

Publications for MSLNL Gene

  1. Inactivation of the MSLNL gene encoding mesothelin-like protein during African great ape evolution. (PMID: 22265842) Kim DW … Hahn Y (Gene 2012) 2 3 54
  2. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. Soluble mesothelin, megakaryocyte potentiating factor, and osteopontin as markers of patient response and outcome in mesothelioma. (PMID: 21841505) Hollevoet K … van Meerbeeck JP (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011) 3 54
  5. Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats. (PMID: 19128473) Sathyanarayana BK … Lee B (BMC structural biology 2009) 23 54

Products for MSLNL Gene

Sources for MSLNL Gene