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Aliases for MSLNL Gene

Aliases for MSLNL Gene

  • Mesothelin-Like 2 3 5
  • Pre-Pro-Megakaryocyte-Potentiating-Factor-Like 3 4
  • C16orf37 3 4
  • MPFL 3 4
  • Chromosome 16 Open Reading Frame 37 2
  • MPF-Like 3

External Ids for MSLNL Gene

Previous HGNC Symbols for MSLNL Gene

  • C16orf37

Previous GeneCards Identifiers for MSLNL Gene

  • GC16M000766
  • GC16M000819
  • GC16M000741
  • GC16M000799
  • GC16M000821
  • GC16M000840
  • GC16M000865
  • GC16M000884
  • GC16M000900
  • GC16M000920

Summaries for MSLNL Gene

GeneCards Summary for MSLNL Gene

MSLNL (Mesothelin-Like) is a Pseudogene. An important paralog of this gene is MSLN.

UniProtKB/Swiss-Prot for MSLNL Gene

  • May play a role in cellular adhesion.

Additional gene information for MSLNL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSLNL Gene

Genomics for MSLNL Gene

GeneHancer (GH) Regulatory Elements for MSLNL Gene

Promoters and enhancers for MSLNL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I000787 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.1 -5.3 -5250 2.8 PKNOX1 ARID4B SIN3A ZNF2 ZNF207 ZNF143 FOS SP3 MXD4 REST CHTF18 GC16M000948 RPUSD1 WDR90 CRAMP1 ENSG00000261207 WDR24 ENSG00000260051 MSLN MSLNL
GH16I000785 Enhancer 0.8 ENCODE 0.8 -2.4 -2366 0.2 HDGF HDAC1 RB1 ARID4B SIN3A ZBTB40 ZNF2 ZNF48 RAD21 ZNF335 RPUSD1 GC16M000948 MSLNL
GH16I000769 Enhancer 0.2 ENCODE 0.4 +13.9 13914 0.2 ENSG00000279136 GC16P000993 MIR662 MSLNL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MSLNL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MSLNL gene promoter:

Genomic Locations for MSLNL Gene

Genomic Locations for MSLNL Gene
13,943 bases
Minus strand

Genomic View for MSLNL Gene

Genes around MSLNL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSLNL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSLNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSLNL Gene

Proteins for MSLNL Gene

  • Protein details for MSLNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mesothelin-like protein
    Protein Accession:

    Protein attributes for MSLNL Gene

    702 amino acids
    Molecular mass:
    74540 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK61254.1; Type=Erroneous gene model prediction; Note=The sequence shown is based on gene prediction by similarity with the mouse ortholog.; Evidence={ECO:0000305}; Sequence=EAW85717.1; Type=Erroneous gene model prediction; Note=The sequence shown is based on gene prediction by similarity with the mouse ortholog.; Evidence={ECO:0000305};

neXtProt entry for MSLNL Gene

Post-translational modifications for MSLNL Gene

  • Glycosylation at isoforms=122, Asn307, and Asn424
  • Modification sites at PhosphoSitePlus

Other Protein References for MSLNL Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MSLNL Gene

Domains & Families for MSLNL Gene

Gene Families for MSLNL Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MSLNL Gene

Suggested Antigen Peptide Sequences for MSLNL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mesothelin family.
  • Belongs to the mesothelin family.
genes like me logo Genes that share domains with MSLNL: view

Function for MSLNL Gene

Molecular function for MSLNL Gene

UniProtKB/Swiss-Prot Function:
May play a role in cellular adhesion.

Phenotypes From GWAS Catalog for MSLNL Gene

Phenotypes for MSLNL Gene

GenomeRNAi human phenotypes for MSLNL:
genes like me logo Genes that share phenotypes with MSLNL: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MSLNL Gene

Localization for MSLNL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSLNL Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSLNL gene
Compartment Confidence
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MSLNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MSLNL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MSLNL Gene

Pathways & Interactions for MSLNL Gene

SuperPathways for MSLNL Gene

No Data Available

Interacting Proteins for MSLNL Gene

Gene Ontology (GO) - Biological Process for MSLNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion IBA --
genes like me logo Genes that share ontologies with MSLNL: view

No data available for Pathways by source and SIGNOR curated interactions for MSLNL Gene

Drugs & Compounds for MSLNL Gene

No Compound Related Data Available

Transcripts for MSLNL Gene

mRNA/cDNA for MSLNL Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSLNL Gene

No ASD Table

Relevant External Links for MSLNL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MSLNL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MSLNL Gene

mRNA differential expression in normal tissues according to GTEx for MSLNL Gene

This gene is overexpressed in Brain - Cortex (x7.1), Lung (x5.0), Fallopian Tube (x4.8), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Putamen (basal ganglia) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of MSLNL Gene:


Evidence on tissue expression from TISSUES for MSLNL Gene

  • Bone(2.4)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with MSLNL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MSLNL Gene

Orthologs for MSLNL Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSLNL Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MSLNL 34
  • 69 (a)
(Bos Taurus)
Mammalia MSLNL 34
  • 68 (a)
(Mus musculus)
Mammalia Mslnl 34
  • 61 (a)
(Pan troglodytes)
Mammalia MSLNL 34
  • 59 (a)
(Monodelphis domestica)
Mammalia MSLNL 34
  • 20 (a)
(Anolis carolinensis)
Reptilia MSLNL 34
  • 38 (a)
Species where no ortholog for MSLNL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MSLNL Gene

Gene Tree for MSLNL (if available)
Gene Tree for MSLNL (if available)

Paralogs for MSLNL Gene

Paralogs for MSLNL Gene

genes like me logo Genes that share paralogs with MSLNL: view

Variants for MSLNL Gene

Sequence variations from dbSNP and Humsavar for MSLNL Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs12599363 -- p.Asp463Val
rs9746539 -- p.Ser597Gly

Variation tolerance for MSLNL Gene

Gene Damage Index Score: 19.80; 98.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MSLNL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MSLNL Gene

Disorders for MSLNL Gene

No disorders were found for MSLNL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for MSLNL Gene

Publications for MSLNL Gene

  1. Inactivation of the MSLNL gene encoding mesothelin-like protein during African great ape evolution. (PMID: 22265842) Kim DW … Hahn Y (Gene 2012) 2 3 58
  2. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 58
  3. Soluble mesothelin, megakaryocyte potentiating factor, and osteopontin as markers of patient response and outcome in mesothelioma. (PMID: 21841505) Hollevoet K … van Meerbeeck JP (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011) 3 58
  4. Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats. (PMID: 19128473) Sathyanarayana BK … Lee B (BMC structural biology 2009) 22 58
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 58

Products for MSLNL Gene

Sources for MSLNL Gene

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