Aliases for MSL3 Gene
Aliases for MSL3 Gene
- MSL Complex Subunit 3 2 3 5
- Male-Specific Lethal-3 Protein-Like 1 3 4
- MSL3-Like 1 3 4
- MSL3L1 3 4
- Male-Specific Lethal 3 Homolog (Drosophila) 2
- Male-Specific Lethal-3 (Drosophila)-Like 1 2
- Male-Specific Lethal 3-Like 1 (Drosophila) 2
- Male-Specific Lethal-3 Homolog 1 4
- Male-Specific Lethal 3 Homolog 3
External Ids for MSL3 Gene
- HGNC: 7370
- Entrez Gene: 10943
- Ensembl: ENSG00000005302
- OMIM: 300609
- UniProtKB: Q8N5Y2
Previous HGNC Symbols for MSL3 Gene
- MSL3L1
Previous GeneCards Identifiers for MSL3 Gene
- GC0XP011687
- GC0XP009555
Summaries for MSL3 Gene
-
This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]
GeneCards Summary for MSL3 Gene
MSL3 (MSL Complex Subunit 3) is a Protein Coding gene. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and methylated histone binding.
UniProtKB/Swiss-Prot for MSL3 Gene
-
May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at Lys-16 which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at Lys-20 (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSL3 Gene
Genomics for MSL3 Gene
GeneHancer (GH) Regulatory Elements for MSL3 Gene
Promoters and enhancers for MSL3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XI011756 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 555.5 | +1.1 | 1118 | 4.6 | ATF1 PKNOX1 ARID4B SIN3A YY1 ETS1 ZNF766 GLIS2 ZNF143 ATF7 | MSL3 ENSG00000282840 ENSG00000206792 GC0XM012054 | |
| GH0XI011787 | Enhancer | 0.7 | Ensembl ENCODE | 12.9 | +29.5 | 29542 | 0.6 | CTCF ETV1 ZNF143 MLLT1 RAD21 | MSL3 ENSG00000206792 GC0XM012054 | |
| GH0XI011739 | Enhancer | 0.7 | FANTOM5 | 9.4 | -18.1 | -18146 | 0.2 | BACH1 EBF1 BMI1 BATF IRF4 RELA ATF7 IKZF2 RUNX3 ZBED1 | ARHGAP6 MSL3 LOC105373131 ENSG00000282840 | |
| GH0XI011764 | Enhancer | 0.8 | ENCODE | 5.1 | +6.8 | 6785 | 1.5 | HDGF SMAD1 RB1 TEAD4 TAL1 EBF1 YBX1 TCF12 GATA2 NCOR1 | MSL3 ENSG00000206792 GC0XM012054 | |
| GH0XI011340 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 2.2 | -416.2 | -416173 | 2.4 | FOXA2 SMAD1 ATF1 ARNT YY1 NCOA2 TCF12 ATF7 RUNX3 RXRA | HCCS MSL3 LOC100422628 GC0XM011637 ARHGAP6 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MSL3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MSL3 gene promoter:
Regulatory Element Products
Genomic Locations for MSL3 Gene
Genomic Locations for MSL3 Gene
- chrX:11,758,159-11,775,753
- (GRCh38/hg38)
- Size:
- 17,595 bases
- Orientation:
- Plus strand
- chrX:11,776,278-11,793,872
- (GRCh37/hg19)
Genomic View for MSL3 Gene
Genes around MSL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.2 by Ensembl
- Xp22.2 by Entrez Gene
- Xp22.2 by HGNC
MSL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MSL3 Gene
Proteins for MSL3 Gene
-
Protein details for MSL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N5Y2-MS3L1_HUMAN
- Recommended name:
- Male-specific lethal 3 homolog
- Protein Accession:
- Q8N5Y2
- A6NCU2
- A6NHW8
- A8K165
- B4DUV8
- B7Z227
- Q9UG70
- Q9Y5Z8
Protein attributes for MSL3 Gene
- Size:
- 521 amino acids
- Molecular mass:
- 59824 Da
- Quaternary structure:
-
- Component the MSL histone acetyltransferase complex at least composed of the MOF/KAT8, MSL1/hampin, MSL2 and MSL3. Interacts (via the MRG domain) with MSL1.
- Miscellaneous:
-
- MSL3L1 gene undergoes X inactivation.
Protein Expression for MSL3 Gene
Post-translational modifications for MSL3 Gene
- Ubiquitination at isoforms=2, 3, 4, 5, 6289
Other Protein References for MSL3 Gene
Antibody Products
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Protein Products
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- antibodies-online: Search results for 5 available MSL3 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for MSL3
Assay Products
- antibodies-online: Search results for available MSL3 related products ranked by validation data
No data available for DME Specific Peptides for MSL3 Gene
Domains & Families for MSL3 Gene
Gene Families for MSL3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MSL3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MSL3 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MSL3 Gene
Function for MSL3 Gene
Molecular function for MSL3 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at Lys-16 which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at Lys-20 (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IDA | 20657587 |
| GO:0035064 | methylated histone binding | IDA | 20657587 |
Phenotypes for MSL3 Gene
- GenomeRNAi human phenotypes for MSL3:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Decreased viability ratio
- Dynamic nuclei (hole, folded or small irregular)
- FOXO1 nuclear localization
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased IL-8 secretion
- Weakly decreased NFAT1-GFP nuclear translocation
- Downregulation of Wnt pathway after Wnt3A stimulation
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for MSL3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MSL3 gene
- Search ViGene Biosciences for MSL3
CRISPR Products
-
OriGene CRISPR knockouts for MSL3
- genomics-online: gRNA clones - Search results for 132 available MSL3 gene related products
- Overview of 132 available MSL3 gene related products
- Applied Biological Materials CRISPR for MSL3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MSL3
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miRNA for MSL3 Gene
- miRTarBase miRNAs that target MSL3
-
- hsa-mir-421 (MIRT039372)
- hsa-mir-484 (MIRT042164)
- hsa-mir-186-5p (MIRT045135)
- hsa-mir-185-5p (MIRT045319)
- hsa-mir-10b-5p (MIRT047419)
- hsa-mir-10a-5p (MIRT047555)
- hsa-mir-148a-3p (MIRT048029)
- hsa-mir-196a-5p (MIRT048163)
- hsa-mir-92a-3p (MIRT049772)
- hsa-mir-26a-5p (MIRT050069)
- hsa-mir-18a-5p (MIRT050657)
- hsa-mir-16-5p (MIRT051183)
- hsa-let-7f-5p (MIRT051352)
miRNA Products
- Search ViGene Biosciences for MSL3
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for MSL3
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- genomics-online: shRNA clones - Search results for 132 available MSL3 gene related products
- Overview of 132 available MSL3 gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for MSL3 gene
Clone Products
-
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- VectorBuilder custom plasmid, inducible vectors for MSL3
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MSL3
- Applied Biological Materials Clones for MSL3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MSL3
-
ViGene Biosciences adenoviral particle packaged cDNA for MSL3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MSL3 gene
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSL3 Gene
Localization for MSL3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MSL3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0035267 | NuA4 histone acetyltransferase complex | IBA | -- |
| GO:0072487 | MSL complex | IDA | 20018852 |
Pathways & Interactions for MSL3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin organization | ||
Pathways by source for MSL3 Gene
3 Reactome pathways for MSL3 Gene
Interacting Proteins for MSL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006338 | chromatin remodeling | IBA | -- |
| GO:0006342 | chromatin silencing | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for MSL3 Gene
Transcripts for MSL3 Gene
mRNA/cDNA for MSL3 Gene
- (8) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (187) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MSL3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MSL3
- genomics-online: gRNA clones - Search results for 132 available MSL3 gene related products
- Overview of 132 available MSL3 gene related products
- Applied Biological Materials CRISPR for MSL3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MSL3
- GenScript: Design CRISPR guide RNA sequences for MSL3
miRNA Products
- Search ViGene Biosciences for MSL3
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for MSL3
- Browse OriGene Inhibitory RNA Products For MSL3
- genomics-online: shRNA clones - Search results for 132 available MSL3 gene related products
- Overview of 132 available MSL3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MSL3 gene
Clone Products
-
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MSL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MSL3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MSL3
- Applied Biological Materials Clones for MSL3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MSL3 Gene
mRNA differential expression in normal tissues according to GTEx for MSL3 Gene
This gene is overexpressed in Whole Blood (x10.2).
This gene is overexpressed in Peripheral blood mononuclear cells (38.4) and Esophagus (16.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MSL3 Gene
NURSA nuclear receptor signaling pathways regulating expression of MSL3 Gene:
MSL3SOURCE GeneReport for Unigene cluster for MSL3 Gene:
Hs.655288mRNA Expression by UniProt/SwissProt for MSL3 Gene:
Q8N5Y2-MS3L1_HUMAN
Tissue specificity:
Expressed in many tissues including liver, pancreas, heart, lung, kidney, skeletal muscle, brain, and placenta, with highest expression in skeletal muscle and heart.
Evidence on tissue expression from TISSUES for MSL3 Gene
- Nervous system(4.7)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for MSL3
-
OriGene qPCR primer pairs and template standards for MSL3
- genomics-online: primer clones - Search results for 132 available MSL3 gene related products
- Overview of 132 available MSL3 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MSL3 Gene
Orthologs for MSL3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MSL3 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MSL3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MSL3 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MSL3 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Msl3 33 16 34 |
|
||
| Msl3l2 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Msl3 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MSL3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MSL3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MSL3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | msl3 33 |
|
||
| Str.758 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.25372 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | msl-3 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001917 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for MSL3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MSL3 Gene
(1) SIMAP similar genes for MSL3 Gene using alignment to 7 proteins:
Pseudogenes.org Pseudogenes for MSL3 Gene
No data available for Paralogs for MSL3 Gene
Variants for MSL3 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000173511 | -- | 11,769,954(+) | C/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000204598 | -- | 11,769,707(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000213999 | -- | 11,775,949(+) | T/A | downstream_transcript_variant | |
| rs1000406803 | -- | 11,761,462(+) | T/C | intron_variant | |
| rs1000673661 | -- | 11,761,129(+) | G/A | intron_variant |
Residual Variation Intolerance Score:
13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.61;
13.17% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MSL3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MSL3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSL3 Gene
Disorders for MSL3 Gene
Additional Disease Information for MSL3
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MSL3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSL3 Gene
Publications for MSL3 Gene
- Characterization of a novel chromo domain gene in xp22.3 with homology to Drosophila msl-3. (PMID: 10395802) Prakash SK … Zoghbi HY (Genomics 1999) 2 3 4 58
- Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. (PMID: 21217699) Kadlec J … Akhtar A (Nature structural & molecular biology 2011) 3 4 58
- Structural and biochemical studies on the chromo-barrel domain of male specific lethal 3 (MSL3) reveal a binding preference for mono- or dimethyllysine 20 on histone H4. (PMID: 20943666) Moore SA … Scott MJ (The Journal of biological chemistry 2010) 3 4 58
- Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain. (PMID: 20657587) Kim D … Khorasanizadeh S (Nature structural & molecular biology 2010) 3 4 58
- Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. (PMID: 20018852) Cai Y … Conaway RC (The Journal of biological chemistry 2010) 3 4 58
Products for MSL3 Gene
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- Invitrogen Antibodies for MSL3
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- VectorBuilder custom plasmid, inducible vectors for MSL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MSL3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MSL3
- antibodies-online: Search results for 40 available MSL3 Antibodies ranked by validation data
- Compare Top MSL3 Antibodies
- antibodies-online: Search results for available MSL3 related products ranked by validation data
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- genomics-online: cdna clones - Search results for 132 available MSL3 gene related products
- Overview of 132 available MSL3 gene related products
- orf clones - Search results for 132 available MSL3 gene related products
- Overview of 132 available MSL3 gene related products
- genomics-online: gRNA clones - Search results for 132 available MSL3 gene related products
- Overview of 132 available MSL3 gene related products
- genomics-online: primer clones - Search results for 132 available MSL3 gene related products
- Overview of 132 available MSL3 gene related products
- genomics-online: shRNA clones - Search results for 132 available MSL3 gene related products
- Overview of 132 available MSL3 gene related products
Sources for MSL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew