Aliases for MSL2 Gene
External Ids for MSL2 Gene
Previous HGNC Symbols for MSL2 Gene
Previous GeneCards Identifiers for MSL2 Gene
GeneCards Summary for MSL2 Gene
MSL2 (MSL Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Chromatin organization and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include ligase activity.
UniProtKB/Swiss-Prot for MSL2 Gene
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at Lys-35 (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.