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Aliases for MSL2 Gene

Aliases for MSL2 Gene

  • MSL Complex Subunit 2 2 3 5
  • Male-Specific Lethal-2 Homolog 1 3 4
  • Male-Specific Lethal 2-Like 1 3 4
  • Ring Finger Protein 184 2 3
  • MSL2-Like 1 3 4
  • MSL2L1 3 4
  • RNF184 3 4
  • MSL-2 3 4
  • Male-Specific Lethal-2 Homolog (Drosophila) 2
  • Male-Specific Lethal 2 Homolog (Drosophila) 2
  • Male-Specific Lethal 2-Like 1 (Drosophila) 2
  • E3 Ubiquitin-Protein Ligase MSL2 3
  • Male-Specific Lethal 2 Homolog 3
  • Male-Specific Lethal-2 Homolog 4
  • RING Finger Protein 184 4
  • EC 6.3.2.- 4
  • KIAA1585 4

External Ids for MSL2 Gene

Previous HGNC Symbols for MSL2 Gene

  • RNF184
  • MSL2L1

Previous GeneCards Identifiers for MSL2 Gene

  • GC03M137353
  • GC03M135867
  • GC03M133245

Summaries for MSL2 Gene

GeneCards Summary for MSL2 Gene

MSL2 (MSL Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Chromatin organization and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include ligase activity.

UniProtKB/Swiss-Prot for MSL2 Gene

  • Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at Lys-35 (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.

Additional gene information for MSL2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSL2 Gene

Genomics for MSL2 Gene

GeneHancer (GH) Regulatory Elements for MSL2 Gene

Promoters and enhancers for MSL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I136191 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 566.4 +2.4 2377 7.1 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D ZNF610 GLIS1 MSL2 PCCB NCK1 IL20RB NCK1-AS1 GC03P136156
GH03I136860 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 27 -664.7 -664748 3.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 NCK1 NCK1-AS1 STAG1 IL20RB MSL2 SLC35G2 ENSG00000273486 ENSG00000242968
GH03I136748 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.2 -554.4 -554443 6.2 PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ENSG00000261758 STAG1 IL20RB MSL2 SLC35G2 ENSG00000242968 ENSG00000273486 PCCB LOC100421438
GH03I136802 Enhancer 1.2 Ensembl ENCODE 20.9 -605.5 -605455 0.9 PKNOX1 ZNF133 FEZF1 GLI4 ZNF2 GLIS2 ZNF302 ZNF416 ATF7 JUNB MSL2 SLC35G2 ENSG00000273486 IL20RB-AS1 NCK1 STAG1 IL20RB ENSG00000242968 GC03M136767
GH03I136183 Enhancer 0.7 Ensembl 34.4 +15.7 15692 0.2 ZNF189 ZNF529 ZNF140 ZNF266 ZC3H11A ZNF501 ZNF404 ZNF664 ZNF213 ZNF354C MSL2 STAG1 NCK1 SLC35G2 NCK1-AS1 PCCB GC03P136156
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MSL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MSL2 gene promoter:

Genomic Locations for MSL2 Gene

Genomic Locations for MSL2 Gene
chr3:136,148,918-136,197,393
(GRCh38/hg38)
Size:
48,476 bases
Orientation:
Minus strand
chr3:135,867,760-135,916,083
(GRCh37/hg19)

Genomic View for MSL2 Gene

Genes around MSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSL2 Gene

Proteins for MSL2 Gene

  • Protein details for MSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCI7-MSL2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MSL2
    Protein Accession:
    Q9HCI7
    Secondary Accessions:
    • B4DYL4
    • G5E9I1
    • Q0D2P1
    • Q8NDB4
    • Q9NVS4

    Protein attributes for MSL2 Gene

    Size:
    577 amino acids
    Molecular mass:
    62541 Da
    Quaternary structure:
    • Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Forms a MSL heterotetrameric core with MSL1.
    SequenceCaution:
    • Sequence=AAH32719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91673.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13411.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MSL2 Gene

    Alternative splice isoforms for MSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSL2 Gene

Post-translational modifications for MSL2 Gene

  • Ubiquitination at isoforms=26
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MSL2 Gene

Domains & Families for MSL2 Gene

Gene Families for MSL2 Gene

Suggested Antigen Peptide Sequences for MSL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCI7

UniProtKB/Swiss-Prot:

MSL2_HUMAN :
  • Belongs to the MSL2 family.
Family:
  • Belongs to the MSL2 family.
genes like me logo Genes that share domains with MSL2: view

Function for MSL2 Gene

Molecular function for MSL2 Gene

UniProtKB/Swiss-Prot Function:
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at Lys-35 (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.

Enzyme Numbers (IUBMB) for MSL2 Gene

Phenotypes From GWAS Catalog for MSL2 Gene

Gene Ontology (GO) - Molecular Function for MSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA,IEA --
genes like me logo Genes that share ontologies with MSL2: view
genes like me logo Genes that share phenotypes with MSL2: view

miRNA for MSL2 Gene

miRTarBase miRNAs that target MSL2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSL2 Gene

Localization for MSL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSL2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0072487 MSL complex IDA 20018852
genes like me logo Genes that share ontologies with MSL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MSL2 Gene

Pathways & Interactions for MSL2 Gene

genes like me logo Genes that share pathways with MSL2: view

Pathways by source for MSL2 Gene

1 Cell Signaling Technology pathway for MSL2 Gene

Gene Ontology (GO) - Biological Process for MSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043984 histone H4-K16 acetylation IDA 20018852
genes like me logo Genes that share ontologies with MSL2: view

No data available for SIGNOR curated interactions for MSL2 Gene

Drugs & Compounds for MSL2 Gene

No Compound Related Data Available

Transcripts for MSL2 Gene

Unigene Clusters for MSL2 Gene

Male-specific lethal 2 homolog (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSL2 Gene

No ASD Table

Relevant External Links for MSL2 Gene

GeneLoc Exon Structure for
MSL2
ECgene alternative splicing isoforms for
MSL2

Expression for MSL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MSL2 Gene

This gene is overexpressed in Breast (37.7), Liver, secretome (17.2), and Cerebrospinal fluid (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MSL2 Gene



NURSA nuclear receptor signaling pathways regulating expression of MSL2 Gene:

MSL2

SOURCE GeneReport for Unigene cluster for MSL2 Gene:

Hs.18631

Evidence on tissue expression from TISSUES for MSL2 Gene

  • Lymph node(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MSL2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MSL2 Gene

Orthologs for MSL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MSL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSL2 33 34
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia MSL2 34 33
  • 96.76 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MSL2 34 33
  • 96.59 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Msl2 33 16 34
  • 95.32 (n)
rat
(Rattus norvegicus)
Mammalia Msl2 33
  • 93.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MSL2 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSL2 34 33
  • 81.86 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msl2 33
  • 71.98 (n)
zebrafish
(Danio rerio)
Actinopterygii msl2b 33 34
  • 63.6 (n)
msl2a 34
  • 50 (a)
OneToMany
wufb76c07 33
fruit fly
(Drosophila melanogaster)
Insecta msl-2 34
  • 17 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToOne
Species where no ortholog for MSL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSL2 Gene

ENSEMBL:
Gene Tree for MSL2 (if available)
TreeFam:
Gene Tree for MSL2 (if available)

Paralogs for MSL2 Gene

No data available for Paralogs for MSL2 Gene

Variants for MSL2 Gene

Sequence variations from dbSNP and Humsavar for MSL2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000107355 -- 136,148,783(-) C/T downstream_transcript_variant
rs1000161508 -- 136,179,566(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000170226 -- 136,174,728(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000201232 -- 136,174,877(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000232217 -- 136,148,533(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MSL2 Gene

Variant ID Type Subtype PubMed ID
nsv4024 CNV insertion 18451855
nsv955351 CNV duplication 24416366
nsv967069 CNV duplication 23825009

Variation tolerance for MSL2 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MSL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSL2 Gene

Disorders for MSL2 Gene

Additional Disease Information for MSL2

No disorders were found for MSL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSL2 Gene

Publications for MSL2 Gene

  1. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PMID: 16227571) Smith ER … Lucchesi JC (Molecular and cellular biology 2005) 2 3 4 58
  2. Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila. (PMID: 23084835) Hallacli E … Kadlec J (Molecular cell 2012) 3 4 58
  3. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. (PMID: 21726816) Wu L … Dou Y (Molecular cell 2011) 3 4 58
  4. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. (PMID: 16543150) Mendjan S … Akhtar A (Molecular cell 2006) 2 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for MSL2 Gene

Sources for MSL2 Gene

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