Aliases for MSI1 Gene
External Ids for MSI1 Gene
Previous GeneCards Identifiers for MSI1 Gene
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]
GeneCards Summary for MSI1 Gene
MSI1 (Musashi RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with MSI1 include Gallbladder Adenocarcinoma and Brain Cancer. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MSI2.
UniProtKB/Swiss-Prot Summary for MSI1 Gene
RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).