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This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]
MSI1 (Musashi RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with MSI1 include Gallbladder Adenocarcinoma and Deafness, Autosomal Dominant 64. Among its related pathways are Neuroscience and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MSI2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IEA,HDA | 22681889 |
GO:0003727 | single-stranded RNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 30367664 |
GO:0008266 | poly(U) RNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005844 | polysome | IBA | 21873635 |
GO:1990904 | ribonucleoprotein complex | IBA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Neuroscience | ||
2 | Wnt / Hedgehog / Notch | ||
3 | mRNA surveillance pathway | ||
4 | Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers | ||
5 | Neural Stem Cells and Lineage-specific Markers |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007399 | nervous system development | TAS | 9790759 |
GO:0051252 | regulation of RNA metabolic process | IBA | -- |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MSI1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MSI1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MSI1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Msi1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Msi1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MSI1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MSI1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MSI1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MSI1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | msi1 30 |
|
||
Str.3045 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.836 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | msi1 30 31 |
|
OneToMany | |
MSI1 (2 of 2) 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | msi 32 |
|
|
|
sqd 32 |
|
|
|||
Rbp6 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | msi-1 31 32 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HRP1 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
721285 | Likely Benign: not provided | 120,357,901(-) | A/G | INTRON_VARIANT | |
741505 | Benign: not provided | 120,368,059(-) | C/G | SYNONYMOUS_VARIANT | |
VAR_035485 | A breast cancer sample | p.Glu160Gln |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv24462 | CNV | gain | 19812545 |
esv3549883 | CNV | deletion | 23714750 |
nsv1071059 | CNV | deletion | 25765185 |
nsv1110897 | OTHER | inversion | 24896259 |
nsv1131047 | CNV | deletion | 24896259 |
nsv560437 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
gallbladder adenocarcinoma |
|
|
deafness, autosomal dominant 64 |
|
|
brain cancer |
|
|
gliosarcoma |
|
|
medulloblastoma |
|
|