Aliases for MSH4 Gene
External Ids for MSH4 Gene
Previous GeneCards Identifiers for MSH4 Gene
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]
GeneCards Summary for MSH4 Gene
MSH4 (MutS Homolog 4) is a Protein Coding gene. Diseases associated with MSH4 include Fanconi Anemia, Complementation Group A and Premature Ovarian Failure 1. Among its related pathways are Meiosis and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include damaged DNA binding and mismatched DNA binding. An important paralog of this gene is MSH3.
UniProtKB/Swiss-Prot Summary for MSH4 Gene
Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.