Aliases for MSANTD4 Gene

Aliases for MSANTD4 Gene

  • Myb/SANT DNA Binding Domain Containing 4 With Coiled-Coils 2 3 5
  • Myb/SANT-Like DNA-Binding Domain Containing 4 With Coiled-Coils 2 3 4
  • KIAA1826 2 3 4
  • Myb/SANT-Like DNA-Binding Domain-Containing Protein 4 3 4
  • MSANTD4 5

External Ids for MSANTD4 Gene

Previous HGNC Symbols for MSANTD4 Gene

  • KIAA1826

Previous GeneCards Identifiers for MSANTD4 Gene

  • GC11M105866

Summaries for MSANTD4 Gene

GeneCards Summary for MSANTD4 Gene

MSANTD4 (Myb/SANT DNA Binding Domain Containing 4 With Coiled-Coils) is a Protein Coding gene. Diseases associated with MSANTD4 include Arthrogryposis, Distal, Type 10 and Pick Disease Of Brain.

Gene Wiki entry for MSANTD4 Gene

Additional gene information for MSANTD4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MSANTD4 Gene

Genomics for MSANTD4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MSANTD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J106021 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 625.9 +1.2 1233 4.3 SP1 HNRNPL CREB1 TEAD4 PRDM10 ZNF512 IKZF1 ZNF692 BACH1 FOS MSANTD4 HSALNG0086902 AASDHPPT KBTBD3 ENSG00000254433 lnc-MSANTD4-1 GRIA4
GH11J106076 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 606.4 -55.3 -55298 4.2 SP1 HNRNPL CREB1 CTCF ATF7 PRDM10 REST ZNF629 TFE3 KDM1A MSANTD4 KBTBD3 AASDHPPT lnc-MSANTD4-2 LINC02719
GH11J106012 Enhancer 0.7 ENCODE 25.5 +9.3 9342 1.7 ZNF629 JUND ZNF639 CEBPB FOS TRIM24 ATF2 ZNF189 ZNF366 ATF3 MSANTD4 lnc-MSANTD4-1 HSALNG0086902 GRIA4
GH11J106087 Enhancer 0.9 Ensembl ENCODE 9.8 -66.3 -66318 7.4 CTCF FOXA1 REST RAD21 IKZF2 TRIM22 CEBPA EED ARID3A JUND MSANTD4 ENSG00000255065 LINC02719 ENSG00000254433 AASDHPPT KBTBD3 GUCY1A2
GH11J106018 Promoter 0.3 Ensembl 21.9 +3.9 3902 0.2 MSANTD4 HSALNG0086902 lnc-MSANTD4-1 GRIA4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MSANTD4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MSANTD4

Genomic Locations for MSANTD4 Gene

Genomic Locations for MSANTD4 Gene
chr11:105,995,623-106,022,403
(GRCh38/hg38)
Size:
26,781 bases
Orientation:
Minus strand
chr11:105,866,350-105,893,130
(GRCh37/hg19)
Size:
26,781 bases
Orientation:
Minus strand

Genomic View for MSANTD4 Gene

Genes around MSANTD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSANTD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSANTD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSANTD4 Gene

Proteins for MSANTD4 Gene

  • Protein details for MSANTD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCY6-MSD4_HUMAN
    Recommended name:
    Myb/SANT-like DNA-binding domain-containing protein 4
    Protein Accession:
    Q8NCY6
    Secondary Accessions:
    • Q96JK1
    • Q96JZ3
    • Q9H2N4

    Protein attributes for MSANTD4 Gene

    Size:
    345 amino acids
    Molecular mass:
    41150 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG44625.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB47455.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55371.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MSANTD4 Gene

Post-translational modifications for MSANTD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MSANTD4 Gene

Domains & Families for MSANTD4 Gene

Gene Families for MSANTD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MSANTD4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MSANTD4 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein KIAA1826 (K1826_HUMAN)
genes like me logo Genes that share domains with MSANTD4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MSANTD4 Gene

Function for MSANTD4 Gene

Phenotypes From GWAS Catalog for MSANTD4 Gene

Gene Ontology (GO) - Molecular Function for MSANTD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28514442
genes like me logo Genes that share ontologies with MSANTD4: view
genes like me logo Genes that share phenotypes with MSANTD4: view

Animal Model Products

CRISPR Products

miRNA for MSANTD4 Gene

miRTarBase miRNAs that target MSANTD4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MSANTD4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSANTD4 Gene

Localization for MSANTD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSANTD4 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MSANTD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with MSANTD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MSANTD4 Gene

Pathways & Interactions for MSANTD4 Gene

PathCards logo

SuperPathways for MSANTD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MSANTD4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MSANTD4 Gene

Drugs & Compounds for MSANTD4 Gene

No Compound Related Data Available

Transcripts for MSANTD4 Gene

mRNA/cDNA for MSANTD4 Gene

5 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MSANTD4

Alternative Splicing Database (ASD) splice patterns (SP) for MSANTD4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b
SP1:
SP2: - - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for MSANTD4 Gene

GeneLoc Exon Structure for
MSANTD4

Expression for MSANTD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MSANTD4 Gene

Protein differential expression in normal tissues from HIPED for MSANTD4 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MSANTD4 Gene



Protein tissue co-expression partners for MSANTD4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MSANTD4

SOURCE GeneReport for Unigene cluster for MSANTD4 Gene:

Hs.266782

Evidence on tissue expression from TISSUES for MSANTD4 Gene

  • Nervous system(4.7)
  • Skin(4.3)
  • Blood(4.3)
  • Spleen(4.2)
  • Lymph node(4.2)
genes like me logo Genes that share expression patterns with MSANTD4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MSANTD4 Gene

Orthologs for MSANTD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSANTD4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MSANTD4 30 31
  • 99.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MSANTD4 30 31
  • 92.56 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MSANTD4 31
  • 86 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Msantd4 30 17 31
  • 85.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MSANTD4 30 31
  • 85.22 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Msantd4 30
  • 85.08 (n)
Oppossum
(Monodelphis domestica)
Mammalia MSANTD4 31
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MSANTD4 30 31
  • 74.42 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MSANTD4 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia msantd4 30
  • 70.02 (n)
Str.11061 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.13787 30
Zebrafish
(Danio rerio)
Actinopterygii LOC570586 30
  • 58.73 (n)
msantd4 31
  • 43 (a)
OneToOne
Species where no ortholog for MSANTD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MSANTD4 Gene

ENSEMBL:
Gene Tree for MSANTD4 (if available)
TreeFam:
Gene Tree for MSANTD4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MSANTD4: view image

Paralogs for MSANTD4 Gene

No data available for Paralogs for MSANTD4 Gene

Variants for MSANTD4 Gene

Additional dbSNP identifiers (rs#s) for MSANTD4 Gene

Structural Variations from Database of Genomic Variants (DGV) for MSANTD4 Gene

Variant ID Type Subtype PubMed ID
dgv81n21 CNV loss 19592680
nsv1052674 CNV loss 25217958

Variation tolerance for MSANTD4 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MSANTD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSANTD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MSANTD4 Gene

Disorders for MSANTD4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MSANTD4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
arthrogryposis, distal, type 10
  • da10
pick disease of brain
  • lobar atrophy of brain
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MSANTD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MSANTD4 Gene

Publications for MSANTD4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for MSANTD4 Gene

Sources for MSANTD4 Gene