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Aliases for MSANTD2 Gene

Aliases for MSANTD2 Gene

  • Myb/SANT DNA Binding Domain Containing 2 2 3 5
  • Myb/SANT-Like DNA-Binding Domain Containing 2 2 3
  • C11orf61 3 4
  • Myb/SANT-Like DNA-Binding Domain-Containing Protein 2 3
  • Chromosome 11 Open Reading Frame 61 2

External Ids for MSANTD2 Gene

Previous HGNC Symbols for MSANTD2 Gene

  • C11orf61

Previous GeneCards Identifiers for MSANTD2 Gene

  • GC11M124637

Summaries for MSANTD2 Gene

GeneCards Summary for MSANTD2 Gene

MSANTD2 (Myb/SANT DNA Binding Domain Containing 2) is a Protein Coding gene.

Additional gene information for MSANTD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSANTD2 Gene

Genomics for MSANTD2 Gene

GeneHancer (GH) Regulatory Elements for MSANTD2 Gene

Promoters and enhancers for MSANTD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I124799 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 550.8 +0.4 438 3.3 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 ZNF143 SP3 LOC100507283 MSANTD2 ENSG00000254941 GC11M124798 GC11M124799 ENSG00000279342
GH11I124776 Promoter 0.5 EPDnew 550.3 +24.4 24377 0.1 MSANTD2 VSIG2 ESAM ENSG00000254509
GH11I125624 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.8 -825.4 -825397 3.4 MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 MEF2D CHEK1 HP11014 TMEM218 TIRAP MSANTD2 FEZ1 STT3A CCDC15 ACRV1 PUS3
GH11I125591 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.6 -792.1 -792061 3.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B STT3A STT3A-AS1 HP11014 TMEM218 CHEK1 MSANTD2 ENSG00000254509 TIRAP ENSG00000254694 EI24
GH11I124642 Enhancer 1.4 FANTOM5 Ensembl ENCODE 28.7 +156.6 156618 2.5 ATF1 PKNOX1 ARNT YY1 TCF12 POLR2B ZNF766 E2F8 ZNF143 FOS ZNF202 MSANTD2 TMEM218 STT3A ENSG00000254509 SPA17 OR8A1 OR8B4 OR8D1 OR8G1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MSANTD2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MSANTD2 Gene

Genomic Locations for MSANTD2 Gene
chr11:124,766,492-124,800,673
(GRCh38/hg38)
Size:
34,182 bases
Orientation:
Minus strand
chr11:124,636,394-124,670,569
(GRCh37/hg19)

Genomic View for MSANTD2 Gene

Genes around MSANTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSANTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSANTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSANTD2 Gene

Proteins for MSANTD2 Gene

  • Protein details for MSANTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1R3-MSD2_HUMAN
    Recommended name:
    Myb/SANT-like DNA-binding domain-containing protein 2
    Protein Accession:
    Q6P1R3
    Secondary Accessions:
    • B3KRY6
    • Q9H042
    • Q9H5K8

    Protein attributes for MSANTD2 Gene

    Size:
    559 amino acids
    Molecular mass:
    61319 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MSANTD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSANTD2 Gene

Post-translational modifications for MSANTD2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MSANTD2 Gene

Domains & Families for MSANTD2 Gene

Gene Families for MSANTD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MSANTD2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MSANTD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MSANTD2: view

No data available for UniProtKB/Swiss-Prot for MSANTD2 Gene

Function for MSANTD2 Gene

Phenotypes From GWAS Catalog for MSANTD2 Gene

genes like me logo Genes that share phenotypes with MSANTD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSANTD2 Gene

Localization for MSANTD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSANTD2 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MSANTD2 Gene

Pathways & Interactions for MSANTD2 Gene

SuperPathways for MSANTD2 Gene

No Data Available

Interacting Proteins for MSANTD2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000239614%0d%0a9606.ENSP00000358862%0d%0a
Selected Interacting proteins: ENSP00000239614 Q6P1R3-MSD2_HUMAN for MSANTD2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for MSANTD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MSANTD2 Gene

Drugs & Compounds for MSANTD2 Gene

No Compound Related Data Available

Transcripts for MSANTD2 Gene

Unigene Clusters for MSANTD2 Gene

Myb/SANT-like DNA-binding domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSANTD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for MSANTD2 Gene

GeneLoc Exon Structure for
MSANTD2
ECgene alternative splicing isoforms for
MSANTD2

Expression for MSANTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MSANTD2 Gene

Protein differential expression in normal tissues from HIPED for MSANTD2 Gene

This gene is overexpressed in Fetal testis (43.7), Fetal heart (10.9), Placenta (7.2), and Blymphocyte (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MSANTD2 Gene



Protein tissue co-expression partners for MSANTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MSANTD2 Gene:

MSANTD2

SOURCE GeneReport for Unigene cluster for MSANTD2 Gene:

Hs.146079
genes like me logo Genes that share expression patterns with MSANTD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MSANTD2 Gene

Orthologs for MSANTD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSANTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSANTD2 34
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MSANTD2 34
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSANTD2 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msantd2 34
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSANTD2 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSANTD2 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves C11ORF61 34
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSANTD2 34
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22556 33
zebrafish
(Danio rerio)
Actinopterygii MSANTD2 34
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7243 33
Species where no ortholog for MSANTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSANTD2 Gene

ENSEMBL:
Gene Tree for MSANTD2 (if available)
TreeFam:
Gene Tree for MSANTD2 (if available)

Paralogs for MSANTD2 Gene

Pseudogenes.org Pseudogenes for MSANTD2 Gene

genes like me logo Genes that share paralogs with MSANTD2: view

No data available for Paralogs for MSANTD2 Gene

Variants for MSANTD2 Gene

Sequence variations from dbSNP and Humsavar for MSANTD2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000085280 -- 124,796,254(-) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000173968 -- 124,770,149(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000347955 -- 124,769,861(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000367977 -- 124,790,037(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000436402 -- 124,783,882(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MSANTD2 Gene

Variant ID Type Subtype PubMed ID
esv3627988 CNV loss 21293372

Variation tolerance for MSANTD2 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MSANTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSANTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSANTD2 Gene

Disorders for MSANTD2 Gene

Additional Disease Information for MSANTD2

No disorders were found for MSANTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSANTD2 Gene

Publications for MSANTD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage. (PMID: 25772364) Hendriks IA … Vertegaal AC (Cell reports 2015) 4 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for MSANTD2 Gene

Sources for MSANTD2 Gene

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