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Aliases for MS4A8 Gene

Aliases for MS4A8 Gene

  • Membrane Spanning 4-Domains A8 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 8B 2 3
  • Four-Span Transmembrane Protein 4 3 4
  • MS4A8B 3 4
  • 4SPAN4 3 4
  • Membrane-Spanning 4-Domains, Subfamily A, Member 8 2
  • Membrane-Spanning 4-Domains Subfamily A Member 8B 4
  • Membrane-Spanning 4-Domains Subfamily A Member 8 3
  • CD20L5 3
  • MS4A4 3

External Ids for MS4A8 Gene

Previous HGNC Symbols for MS4A8 Gene

  • MS4A8B

Previous GeneCards Identifiers for MS4A8 Gene

  • GC11P060469

Summaries for MS4A8 Gene

Entrez Gene Summary for MS4A8 Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. [provided by RefSeq, Jul 2008]

GeneCards Summary for MS4A8 Gene

MS4A8 (Membrane Spanning 4-Domains A8) is a Protein Coding gene. An important paralog of this gene is MS4A18.

UniProtKB/Swiss-Prot for MS4A8 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

Additional gene information for MS4A8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A8 Gene

Genomics for MS4A8 Gene

GeneHancer (GH) Regulatory Elements for MS4A8 Gene

Promoters and enhancers for MS4A8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I060699 Promoter/Enhancer 1.2 EPDnew ENCODE 556.1 +0.2 178 1.2 ZNF449 ZSCAN4 FEZF1 ZIC2 ZSCAN5C TCF7L2 RFX1 GFI1B ZBTB8A ZEB2 MS4A8 LOC105369321 MS4A18
GH11I060700 Enhancer 0.5 ENCODE 550.8 +1.6 1560 1.2 CTCF GATA3 ZNF654 CUX1 MAFK RAD21 MS4A8 MS4A18
GH11I060683 Enhancer 0.6 ENCODE 16.7 -15.3 -15319 1 PKNOX1 CBFB ZSCAN4 EBF1 ELF1 DPF2 BATF TARDBP IKZF1 ZNF207 MS4A8 MS4A18 LOC105369321 LINC00301
GH11I060717 Enhancer 0.5 ENCODE 15.3 +19.7 19705 3 ZNF680 CREB1 ATF7 BATF ATF2 MS4A8 MS4A10 MS4A1 MS4A18 MS4A14
GH11I060765 Enhancer 0.6 FANTOM5 10.8 +65.6 65577 0.2 SRF BATF KLF5 ATF2 ZBTB40 POLR2A ZFP36 ATF7 ZBTB33 MS4A10 MS4A8 ENSG00000255845 ENSG00000255959 CCDC86 MS4A1 MS4A13 MS4A15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MS4A8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MS4A8 Gene

Genomic Locations for MS4A8 Gene
16,238 bases
Plus strand

Genomic View for MS4A8 Gene

Genes around MS4A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A8 Gene

Proteins for MS4A8 Gene

  • Protein details for MS4A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 8
    Protein Accession:
    Secondary Accessions:
    • Q8TCA5

    Protein attributes for MS4A8 Gene

    250 amino acids
    Molecular mass:
    26290 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MS4A8 Gene

Post-translational modifications for MS4A8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MS4A8 Gene

No data available for DME Specific Peptides for MS4A8 Gene

Domains & Families for MS4A8 Gene

Gene Families for MS4A8 Gene

Protein Domains for MS4A8 Gene

Suggested Antigen Peptide Sequences for MS4A8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A8: view

Function for MS4A8 Gene

Molecular function for MS4A8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.

Phenotypes From GWAS Catalog for MS4A8 Gene

genes like me logo Genes that share phenotypes with MS4A8: view

Animal Model Products

CRISPR Products

miRNA for MS4A8 Gene

miRTarBase miRNAs that target MS4A8

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A8 Gene

Localization for MS4A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A8 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A8 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for MS4A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MS4A8 Gene

Pathways & Interactions for MS4A8 Gene

SuperPathways for MS4A8 Gene

No Data Available

Interacting Proteins for MS4A8 Gene

Gene Ontology (GO) - Biological Process for MS4A8 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A8 Gene

Drugs & Compounds for MS4A8 Gene

No Compound Related Data Available

Transcripts for MS4A8 Gene

Unigene Clusters for MS4A8 Gene

Membrane-spanning 4-domains, subfamily A, member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: - - -

Relevant External Links for MS4A8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A8 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x23.2), Cervix - Endocervix (x7.8), Colon - Transverse (x5.7), and Fallopian Tube (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of MS4A8 Gene:


SOURCE GeneReport for Unigene cluster for MS4A8 Gene:


mRNA Expression by UniProt/SwissProt for MS4A8 Gene:

Tissue specificity: Expressed by hematopoietic tissues and cells lines.

Evidence on tissue expression from TISSUES for MS4A8 Gene

  • Lung(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MS4A8: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A8 Gene

Orthologs for MS4A8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A8B 33
  • 99.47 (n)
MS4A8 34
  • 99 (a)
(Bos Taurus)
Mammalia MS4A8B 33 34
  • 74.76 (n)
(Rattus norvegicus)
Mammalia Ms4a8 33
  • 73.2 (n)
(Mus musculus)
Mammalia Ms4a8a 33 16 34
  • 71.33 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 41 (a)
-- 34
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia MS4A8 34
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
-- 34
  • 34 (a)
-- 34
  • 31 (a)
(Danio rerio)
Actinopterygii ms4a17a.14 34
  • 32 (a)
FP015791.1 34
  • 31 (a)
ms4a17a.6 34
  • 31 (a)
ms4a17a.11 34
  • 31 (a)
si:dkey-77f5.10 34
  • 30 (a)
ms4a17a.5 34
  • 30 (a)
ms4a17a.10 34
  • 30 (a)
si:ch73-56d11.4 34
  • 29 (a)
si:ch73-56d11.3 34
  • 28 (a)
ms4a17a.7 34
  • 28 (a)
ms4a17a.2 34
  • 28 (a)
ms4a17a.1 34
  • 28 (a)
si:dkey-238j22.1 34
  • 27 (a)
ms4a17c.1 34
  • 27 (a)
ms4a17a.4 34
  • 27 (a)
ms4a17a.3 34
  • 26 (a)
ms4a17a.9 34
  • 25 (a)
ms4a17a.8 34
  • 25 (a)
ms4a17c.2 34
  • 24 (a)
si:dkey-174k12.3 34
  • 22 (a)
ms4a17a.17 34
  • 22 (a)
Species where no ortholog for MS4A8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A8 Gene

Gene Tree for MS4A8 (if available)
Gene Tree for MS4A8 (if available)

Paralogs for MS4A8 Gene

Paralogs for MS4A8 Gene

(7) SIMAP similar genes for MS4A8 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MS4A8: view

Variants for MS4A8 Gene

Sequence variations from dbSNP and Humsavar for MS4A8 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000290058 -- 60,710,170(+) C/G intron_variant
rs1000405815 -- 60,710,437(+) G/A intron_variant
rs1000418375 -- 60,704,799(+) A/T intron_variant
rs1000509730 -- 60,709,495(+) C/T intron_variant
rs1000606226 -- 60,703,282(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A8 Gene

Variant ID Type Subtype PubMed ID
esv2744575 CNV deletion 23290073
nsv1051057 CNV loss 25217958
nsv832175 CNV gain 17160897

Variation tolerance for MS4A8 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MS4A8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A8 Gene

Disorders for MS4A8 Gene

Additional Disease Information for MS4A8

No disorders were found for MS4A8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A8 Gene

Publications for MS4A8 Gene

  1. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y … Tedder TF (Genomics 2001) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PMID: 11245982) Ishibashi K … Imai M (Gene 2001) 2 3 58
  4. Identification of the novel differentiation marker MS4A8B and its murine homolog MS4A8A in colonic epithelial cells lost during neoplastic transformation in human colon. (PMID: 23348583) Michel J … Schmieder A (Cell death & disease 2013) 3 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for MS4A8 Gene

Sources for MS4A8 Gene

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