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Aliases for MS4A7 Gene

Aliases for MS4A7 Gene

  • Membrane Spanning 4-Domains A7 2 3 5
  • Four-Span Transmembrane Protein 2 3 4
  • CD20 Antigen-Like 4 3 4
  • 4SPAN2 3 4
  • CD20L4 3 4
  • CFFM4 3 4
  • High Affinity Immunoglobulin Epsilon Receptor Beta Subunit 3
  • Membrane-Spanning 4-Domains, Subfamily A, Member 7 2
  • Membrane-Spanning 4-Domains Subfamily A Member 7 3
  • CD20/Fc-Epsilon-RI-Beta Family Member 4 3
  • CD20/FC-Epsilon-RI-Beta Family Member 4 4
  • MS4A8 3

External Ids for MS4A7 Gene

Previous GeneCards Identifiers for MS4A7 Gene

  • GC11P062539
  • GC11P061659
  • GC11P059921
  • GC11P059902
  • GC11P060145
  • GC11P056492

Summaries for MS4A7 Gene

Entrez Gene Summary for MS4A7 Gene

  • This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for MS4A7 Gene

MS4A7 (Membrane Spanning 4-Domains A7) is a Protein Coding gene. An important paralog of this gene is MS4A6A.

UniProtKB/Swiss-Prot for MS4A7 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

Gene Wiki entry for MS4A7 Gene

Additional gene information for MS4A7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A7 Gene

Genomics for MS4A7 Gene

GeneHancer (GH) Regulatory Elements for MS4A7 Gene

Promoters and enhancers for MS4A7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J060376 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 656.2 -0.4 -413 2.9 PKNOX1 CLOCK SMAD1 BATF IRF4 YY1 FOS ETV6 BCLAF1 IKZF2 MS4A14 MS4A7 MS4A1 GC11P060374 GC11M060363 MS4A6E
GH11J060363 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 669.1 -14.5 -14535 1.7 SMARCA5 CTCF ZNF654 ZBTB6 RB1 HLF MAX TRIM22 REST RAD21 MS4A7 MS4A14 MS4A6E MS4A5 MS4A12 MS4A18 MS4A6A MS4A4A GC11P060374 GC11M060363
GH11J060366 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 16.1 -11.0 -11003 1.7 EBF1 KLF5 RELA NFATC1 EED ZNF143 ATF7 BCLAF1 IKZF2 RUNX3 MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A4A MS4A13 MS4A18 MS4A6A GC11P060374
GH11J060454 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 11.5 +79.0 79048 6.7 PKNOX1 SMAD1 RB1 STAT5A BMI1 YBX1 BATF KLF5 IRF4 ZNF207 MS4A1 MS4A14 MS4A5 MS4A7 MS4A12
GH11J060280 Promoter/Enhancer 1.3 EPDnew FANTOM5 Ensembl ENCODE 8.1 -97.5 -97524 1.9 SRF SPI1 MS4A4A MS4A6E MS4A7 MS4A6A GC11M060297
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MS4A7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MS4A7 gene promoter:
  • CUTL1
  • POU2F1a
  • POU2F1
  • Nkx2-5
  • Evi-1
  • GR-beta
  • GR-alpha
  • GR

Genomic Locations for MS4A7 Gene

Genomic Locations for MS4A7 Gene
17,473 bases
Plus strand
17,473 bases
Plus strand

Genomic View for MS4A7 Gene

Genes around MS4A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A7 Gene

Proteins for MS4A7 Gene

  • Protein details for MS4A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 7
    Protein Accession:
    Secondary Accessions:
    • A6NP53
    • Q6IAG8

    Protein attributes for MS4A7 Gene

    240 amino acids
    Molecular mass:
    26131 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MS4A7 Gene


neXtProt entry for MS4A7 Gene

Post-translational modifications for MS4A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MS4A7 Gene

Domains & Families for MS4A7 Gene

Gene Families for MS4A7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MS4A7 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A7: view

Function for MS4A7 Gene

Molecular function for MS4A7 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.

Phenotypes From GWAS Catalog for MS4A7 Gene

genes like me logo Genes that share phenotypes with MS4A7: view

Animal Model Products

miRNA for MS4A7 Gene

miRTarBase miRNAs that target MS4A7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A7 Gene

Localization for MS4A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A7 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MS4A7 Gene

Pathways & Interactions for MS4A7 Gene

SuperPathways for MS4A7 Gene

No Data Available

Interacting Proteins for MS4A7 Gene

Selected Interacting proteins: Q9GZW8-MS4A7_HUMAN for MS4A7 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MS4A7 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A7 Gene

Drugs & Compounds for MS4A7 Gene

No Compound Related Data Available

Transcripts for MS4A7 Gene

mRNA/cDNA for MS4A7 Gene

Unigene Clusters for MS4A7 Gene

Membrane-spanning 4-domains, subfamily A, member 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7: - - - -
SP8: - - - - - - - - - -
SP9: -

Relevant External Links for MS4A7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A7 Gene

This gene is overexpressed in Spleen (x13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MS4A7 Gene

NURSA nuclear receptor signaling pathways regulating expression of MS4A7 Gene:


SOURCE GeneReport for Unigene cluster for MS4A7 Gene:


mRNA Expression by UniProt/SwissProt for MS4A7 Gene:

Tissue specificity: Ubiquitous expression in normal tissues. Expression is more elevated in adult liver, lung, spleen, and heart than in their fetal counterparts, and is higher in normal tissues than in the cancerous tissue or cell lines. Low levels of expression were detected in the promonocytic stage, whereas high levels of expression were detected in mature monocytes.

Evidence on tissue expression from TISSUES for MS4A7 Gene

  • Spleen(4.4)
  • Lymph node(4.3)
  • Thyroid gland(4.2)
  • Blood(4)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with MS4A7: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A7 Gene

Orthologs for MS4A7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A7 34 33
  • 99.17 (n)
(Bos Taurus)
Mammalia MS4A7 34 33
  • 81.39 (n)
(Canis familiaris)
Mammalia MS4A7 34 33
  • 80.56 (n)
(Rattus norvegicus)
Mammalia Ms4a7 33
  • 71.58 (n)
(Mus musculus)
Mammalia Ms4a7 16 34 33
  • 70.71 (n)
Species where no ortholog for MS4A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A7 Gene

Gene Tree for MS4A7 (if available)
Gene Tree for MS4A7 (if available)
Evolutionary constrained regions (ECRs) for MS4A7: view image

Paralogs for MS4A7 Gene

Paralogs for MS4A7 Gene

(2) SIMAP similar genes for MS4A7 Gene using alignment to 5 proteins:

  • E9PL98_HUMAN
  • E9PM26_HUMAN
  • E9PN40_HUMAN
genes like me logo Genes that share paralogs with MS4A7: view

Variants for MS4A7 Gene

Sequence variations from dbSNP and Humsavar for MS4A7 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000020281 -- 60,387,519(+) C/G intron_variant
rs1000292754 -- 60,381,529(+) A/G intron_variant
rs1000507269 -- 60,394,437(+) T/C 3_prime_UTR_variant
rs1000827299 -- 60,395,049(+) A/G 3_prime_UTR_variant
rs1000866317 -- 60,386,536(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A7 Gene

Variant ID Type Subtype PubMed ID
esv2744569 CNV deletion 23290073

Variation tolerance for MS4A7 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.47; 55.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MS4A7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A7 Gene

Disorders for MS4A7 Gene

Additional Disease Information for MS4A7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MS4A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A7 Gene

Publications for MS4A7 Gene

  1. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PMID: 11245982) Ishibashi K … Imai M (Gene 2001) 2 3 4 58
  2. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y … Tedder TF (Genomics 2001) 2 3 4 58
  3. CFFM4: a new member of the CD20/FcepsilonRIbeta family. (PMID: 11685457) Gingras MC … Margolin JF (Immunogenetics 2001) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for MS4A7 Gene

Sources for MS4A7 Gene

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