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Aliases for MS4A6E Gene

Aliases for MS4A6E Gene

  • Membrane Spanning 4-Domains A6E 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 6E 2

External Ids for MS4A6E Gene

Previous GeneCards Identifiers for MS4A6E Gene

  • GC11P062496
  • GC11P061615
  • GC11P059877
  • GC11P059858
  • GC11P060102
  • GC11P056449

Summaries for MS4A6E Gene

Entrez Gene Summary for MS4A6E Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. [provided by RefSeq, Jul 2008]

GeneCards Summary for MS4A6E Gene

MS4A6E (Membrane Spanning 4-Domains A6E) is a Protein Coding gene. An important paralog of this gene is MS4A6A.

UniProtKB/Swiss-Prot for MS4A6E Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

Additional gene information for MS4A6E Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A6E Gene

Genomics for MS4A6E Gene

GeneHancer (GH) Regulatory Elements for MS4A6E Gene

Promoters and enhancers for MS4A6E Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I060335 Enhancer 0.5 ENCODE 555.2 -0.4 -408 0.2 CTCF TRIM22 ZNF143 SMC3 IRF4 RAD21 MS4A6E GC11M060301
GH11I060334 Enhancer 0.5 ENCODE 555 -0.7 -658 0.2 CTCF TRIM22 ZNF143 SMC3 IRF4 RAD21 MS4A6E GC11M060301
GH11I060333 Enhancer 0.2 Ensembl 555 -1.5 -1530 0.2 MS4A6E GC11M060301
GH11I060363 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +29.1 29116 1.7 SMARCA5 CTCF ZNF654 ZBTB6 RB1 HLF MAX TRIM22 REST RAD21 MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A18 MS4A6A MS4A4A GC11P060374 GC11M060363
GH11I060310 Enhancer 0.9 Ensembl ENCODE 16.1 -24.1 -24083 1.1 PKNOX1 BACH1 BMI1 IRF4 ATF7 ZSCAN29 BCLAF1 IKZF2 RUNX3 SMARCA5 MS4A6E MS4A12 MS4A18 GC11M060301
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MS4A6E on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MS4A6E gene promoter:

Genomic Locations for MS4A6E Gene

Genomic Locations for MS4A6E Gene
61,766 bases
Plus strand

Genomic View for MS4A6E Gene

Genes around MS4A6E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A6E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A6E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A6E Gene

Proteins for MS4A6E Gene

  • Protein details for MS4A6E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 6E
    Protein Accession:
    Secondary Accessions:
    • Q3MIL2
    • Q8NE56
    • Q96PG4
    • Q96PG5

    Protein attributes for MS4A6E Gene

    147 amino acids
    Molecular mass:
    15909 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MS4A6E Gene

Post-translational modifications for MS4A6E Gene

No Post-translational modifications

Other Protein References for MS4A6E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MS4A6E Gene

Domains & Families for MS4A6E Gene

Gene Families for MS4A6E Gene

Protein Domains for MS4A6E Gene

Suggested Antigen Peptide Sequences for MS4A6E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A6E: view

Function for MS4A6E Gene

Molecular function for MS4A6E Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.

Phenotypes From GWAS Catalog for MS4A6E Gene

genes like me logo Genes that share phenotypes with MS4A6E: view

Animal Model Products

CRISPR Products

miRNA for MS4A6E Gene

miRTarBase miRNAs that target MS4A6E

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A6E Gene

Localization for MS4A6E Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A6E Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A6E gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A6E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A6E: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MS4A6E Gene

Pathways & Interactions for MS4A6E Gene

SuperPathways for MS4A6E Gene

No Data Available

Interacting Proteins for MS4A6E Gene

Selected Interacting proteins: Q96DS6-M4A6E_HUMAN for MS4A6E Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MS4A6E Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A6E Gene

Drugs & Compounds for MS4A6E Gene

No Compound Related Data Available

Transcripts for MS4A6E Gene

mRNA/cDNA for MS4A6E Gene

Unigene Clusters for MS4A6E Gene

Membrane-spanning 4-domains, subfamily A, member 6E:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A6E Gene

No ASD Table

Relevant External Links for MS4A6E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A6E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A6E Gene

mRNA differential expression in normal tissues according to GTEx for MS4A6E Gene

This gene is overexpressed in Testis (x43.4).

NURSA nuclear receptor signaling pathways regulating expression of MS4A6E Gene:


SOURCE GeneReport for Unigene cluster for MS4A6E Gene:


mRNA Expression by UniProt/SwissProt for MS4A6E Gene:

Tissue specificity: Expressed by malignant and fetal tissue at very low levels.

Evidence on tissue expression from TISSUES for MS4A6E Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with MS4A6E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A6E Gene

Orthologs for MS4A6E Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A6E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A6E 33 34
  • 99.09 (n)
(Canis familiaris)
Mammalia -- 34
  • 33 (a)
(Mus musculus)
Mammalia Ms4a6d 34
  • 31 (a)
Ms4a6c 34
  • 29 (a)
Ms4a6b 34
  • 27 (a)
Gm10212 34
  • 20 (a)
Species where no ortholog for MS4A6E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A6E Gene

Gene Tree for MS4A6E (if available)
Gene Tree for MS4A6E (if available)

Paralogs for MS4A6E Gene

Paralogs for MS4A6E Gene

(2) SIMAP similar genes for MS4A6E Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MS4A6E: view

Variants for MS4A6E Gene

Sequence variations from dbSNP and Humsavar for MS4A6E Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000343296 -- 60,339,142(+) A/T intron_variant
rs1000794216 -- 60,338,227(+) T/A intron_variant
rs1001555925 -- 60,332,915(+) T/C upstream_transcript_variant
rs1001780995 -- 60,338,615(+) A/G intron_variant
rs1002807451 -- 60,337,628(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A6E Gene

Variant ID Type Subtype PubMed ID
esv2744569 CNV deletion 23290073
esv3626556 CNV gain 21293372
esv3892019 CNV loss 25118596

Variation tolerance for MS4A6E Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.45; 82.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MS4A6E Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A6E Gene

Disorders for MS4A6E Gene

Additional Disease Information for MS4A6E

No disorders were found for MS4A6E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A6E Gene

Publications for MS4A6E Gene

  1. Structural organization of the human MS4A gene cluster on Chromosome 11q12. (PMID: 11486273) Liang Y … Tedder TF (Immunogenetics 2001) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. (PMID: 23383108) Denner J … Akyüz L (PloS one 2013) 3 58
  4. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. (PMID: 21460841) Naj AC … Schellenberg GD (Nature genetics 2011) 3 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for MS4A6E Gene

Sources for MS4A6E Gene

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