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Aliases for MS4A5 Gene

Aliases for MS4A5 Gene

  • Membrane Spanning 4-Domains A5 2 3 5
  • Testis-Expressed Transmembrane Protein 4 3 4
  • CD20 Antigen-Like 2 3 4
  • CD20L2 3 4
  • TETM4 3 4
  • Membrane-Spanning 4-Domains, Subfamily A, Member 5 2
  • Membrane-Spanning 4-Domains Subfamily A Member 5 3
  • Testis-Expressed Transmembrane-4 Protein 3
  • CD20-L2 3

External Ids for MS4A5 Gene

Previous GeneCards Identifiers for MS4A5 Gene

  • GC11P062590
  • GC11P061710
  • GC11P059972
  • GC11P059953
  • GC11P060197
  • GC11P056544

Summaries for MS4A5 Gene

Entrez Gene Summary for MS4A5 Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. Though this member is not expressed in hematopoietic cells specifically, it may be involved in signal transduction like many of its related family members. The gene encoding this protein is localized to 11q12, among a cluster of family members. [provided by RefSeq, Jul 2008]

GeneCards Summary for MS4A5 Gene

MS4A5 (Membrane Spanning 4-Domains A5) is a Protein Coding gene. An important paralog of this gene is MS4A14.

UniProtKB/Swiss-Prot for MS4A5 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

Additional gene information for MS4A5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A5 Gene

Genomics for MS4A5 Gene

GeneHancer (GH) Regulatory Elements for MS4A5 Gene

Promoters and enhancers for MS4A5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I060429 Promoter 0.5 EPDnew 550.8 0.0 -26 0.1 MS4A5 GC11M060363
GH11I060454 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 11.9 +27.9 27941 6.7 PKNOX1 SMAD1 RB1 BMI1 YBX1 BATF KLF5 IRF4 ZNF207 ZNF143 MS4A1 MS4A14 MS4A5 MS4A7 MS4A12
GH11I060396 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 11.3 -32.5 -32531 2 SRF CREB1 IRF4 RUNX3 SPI1 MS4A14 MS4A1 MS4A5 GC11M060363 MS4A6E
GH11I060363 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -65.6 -65642 1.7 SMARCA5 CTCF ZNF654 ZBTB6 RB1 HLF MAX TRIM22 REST RAD21 MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A18 MS4A6A MS4A4A GC11P060374 GC11M060363
GH11I060366 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.4 -62.1 -62110 1.7 EBF1 KLF5 RELA NFATC1 ZNF143 ATF7 BCLAF1 IKZF2 RUNX3 SRF MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A4A MS4A13 MS4A18 MS4A6A GC11P060374
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MS4A5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MS4A5 gene promoter:

Genomic Locations for MS4A5 Gene

Genomic Locations for MS4A5 Gene
25,626 bases
Plus strand

Genomic View for MS4A5 Gene

Genes around MS4A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A5 Gene

Proteins for MS4A5 Gene

  • Protein details for MS4A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 5
    Protein Accession:
    Secondary Accessions:
    • Q9BZH1

    Protein attributes for MS4A5 Gene

    200 amino acids
    Molecular mass:
    22283 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MS4A5 Gene

Post-translational modifications for MS4A5 Gene

No Post-translational modifications

Other Protein References for MS4A5 Gene

No data available for DME Specific Peptides for MS4A5 Gene

Domains & Families for MS4A5 Gene

Gene Families for MS4A5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MS4A5 Gene


Suggested Antigen Peptide Sequences for MS4A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A5: view

Function for MS4A5 Gene

Molecular function for MS4A5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.

Phenotypes From GWAS Catalog for MS4A5 Gene

genes like me logo Genes that share phenotypes with MS4A5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MS4A5

miRNA for MS4A5 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A5 Gene

Localization for MS4A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A5 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MS4A5 Gene

Pathways & Interactions for MS4A5 Gene

SuperPathways for MS4A5 Gene

No Data Available

Interacting Proteins for MS4A5 Gene

Selected Interacting proteins: Q9H3V2-MS4A5_HUMAN for MS4A5 Gene via IID

Gene Ontology (GO) - Biological Process for MS4A5 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A5 Gene

Drugs & Compounds for MS4A5 Gene

No Compound Related Data Available

Transcripts for MS4A5 Gene

Unigene Clusters for MS4A5 Gene

Membrane-spanning 4-domains, subfamily A, member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A5 Gene

No ASD Table

Relevant External Links for MS4A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A5 Gene

mRNA differential expression in normal tissues according to GTEx for MS4A5 Gene

This gene is overexpressed in Testis (x52.8).

NURSA nuclear receptor signaling pathways regulating expression of MS4A5 Gene:


SOURCE GeneReport for Unigene cluster for MS4A5 Gene:


mRNA Expression by UniProt/SwissProt for MS4A5 Gene:

Tissue specificity: Expressed at high level in the testis. Detected also in the pancreas, heart and in the brain.

Evidence on tissue expression from TISSUES for MS4A5 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with MS4A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A5 Gene

Orthologs for MS4A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A5 33 34
  • 99.33 (n)
(Canis familiaris)
Mammalia MS4A5 33
  • 81.22 (n)
(Bos Taurus)
Mammalia MS4A5 33 34
  • 77.1 (n)
(Rattus norvegicus)
Mammalia Ms4a5 33
  • 77.1 (n)
(Mus musculus)
Mammalia Ms4a5 33 16 34
  • 77.04 (n)
(Monodelphis domestica)
Mammalia MS4A5 34
  • 43 (a)
Species where no ortholog for MS4A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A5 Gene

Gene Tree for MS4A5 (if available)
Gene Tree for MS4A5 (if available)

Paralogs for MS4A5 Gene

Paralogs for MS4A5 Gene

(4) SIMAP similar genes for MS4A5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MS4A5: view

Variants for MS4A5 Gene

Sequence variations from dbSNP and Humsavar for MS4A5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
VAR_036402 A colorectal cancer sample p.Leu123Arg
rs1000044168 -- 60,428,472(+) T/C upstream_transcript_variant
rs1000136976 -- 60,444,395(+) C/T intron_variant
rs1000352963 -- 60,428,737(+) G/C upstream_transcript_variant
rs1000742442 -- 60,443,191(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A5 Gene

Variant ID Type Subtype PubMed ID
dgv51n111 CNV deletion 26073780
esv2744569 CNV deletion 23290073
nsv508635 CNV deletion 20534489

Variation tolerance for MS4A5 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.87; 67.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MS4A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A5 Gene

Disorders for MS4A5 Gene

Additional Disease Information for MS4A5

No disorders were found for MS4A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A5 Gene

Publications for MS4A5 Gene

  1. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PMID: 11245982) Ishibashi K … Imai M (Gene 2001) 2 3 4 58
  2. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y … Tedder TF (Genomics 2001) 2 3 4 58
  3. Isolation, tissue distribution, and chromosomal localization of a novel testis-specific human four-transmembrane gene related to CD20 and FcepsilonRI-beta. (PMID: 11162526) Hulett MD … Parish CR (Biochemical and biophysical research communications 2001) 3 4 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Structural organization of the human MS4A gene cluster on Chromosome 11q12. (PMID: 11486273) Liang Y … Tedder TF (Immunogenetics 2001) 3 22 58

Products for MS4A5 Gene

Sources for MS4A5 Gene

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