This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gen... See more...

Aliases for MS4A4A Gene

Aliases for MS4A4A Gene

  • Membrane Spanning 4-Domains A4A 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 4 2 3
  • Membrane-Spanning 4-Domains Subfamily A Member 4A 3 4
  • Four-Span Transmembrane Protein 1 3 4
  • CD20 Antigen-Like 1 3 4
  • 4SPAN1 3 4
  • CD20L1 3 4
  • MS4A4 3 4
  • Membrane-Spanning 4-Domains, Subfamily A, Member 4A 2
  • Epididymis Secretory Sperm Binding Protein 3
  • Fc Epsilon Receptor Beta Subunit Homolog 3
  • HDCME31P 3
  • CD20-L1 3
  • MS4A7 3

External Ids for MS4A4A Gene

Previous HGNC Symbols for MS4A4A Gene

  • MS4A4

Previous GeneCards Identifiers for MS4A4A Gene

  • GC11P062442
  • GC11P061561
  • GC11P060298
  • GC11P059823
  • GC11P059804
  • GC11P060048
  • GC11P056394

Summaries for MS4A4A Gene

Entrez Gene Summary for MS4A4A Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for MS4A4A Gene

MS4A4A (Membrane Spanning 4-Domains A4A) is a Protein Coding gene. An important paralog of this gene is MS4A4E.

UniProtKB/Swiss-Prot Summary for MS4A4A Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

Additional gene information for MS4A4A Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MS4A4A Gene

Genomics for MS4A4A Gene

GeneHancer (GH) Regulatory Elements for MS4A4A Gene

Promoters and enhancers for MS4A4A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J060280 Promoter/Enhancer 1 EPDnew FANTOM5 Ensembl ENCODE 757.4 +95.3 95303 2 MS4A4A NONHSAG008427.2 MS4A6E MS4A7 MS4A6A piR-43105-088
GH11J060366 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 10.6 +181.8 181777 1.7 ZNF24 RELA MLLT1 IKZF1 TRIM22 IKZF2 ZNF143 EED ELF1 BCL11A MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A4A MS4A13 MS4A18 MS4A6A HSALNG0084460
GH11J060363 Promoter/Enhancer 1.3 EPDnew FANTOM5 ENCODE dbSUPER 6.7 +178.3 178253 1.7 CTCF ZBTB6 HLF MAX RAD21 REST TRIM22 ZNF143 SMC3 SMARCA5 MS4A7 HSALNG0084460 MS4A14 MS4A6E MS4A5 MS4A12 MS4A18 MS4A6A MS4A4A lnc-MS4A7-1
GH11J060251 Enhancer 0.8 Ensembl ENCODE 5.8 +66.8 66799 3.8 CTCF CC2D1A RAD21 ZNF680 ARID2 RXRA REST TRIM22 ZNF143 NFE2L2 MS4A6E STX3 TCN1 OOSP2 MS4A6A MS4A4A MS4A4E NONHSAG008427.2
GH11J060220 Enhancer 0.5 Ensembl 6.1 +36.8 36799 3.4 FOSL1 CEBPG CEBPB FOS JUN MS4A6E MS4A6A MS4A4A MS4A4E MIR6503
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MS4A4A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MS4A4A gene promoter:
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for MS4A4A Gene

Genomic Locations for MS4A4A Gene
chr11:60,185,702-60,317,944
(GRCh38/hg38)
Size:
132,243 bases
Orientation:
Plus strand
chr11:60,048,014-60,076,445
(GRCh37/hg19)
Size:
28,432 bases
Orientation:
Plus strand

Genomic View for MS4A4A Gene

Genes around MS4A4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A4A Gene

Proteins for MS4A4A Gene

  • Protein details for MS4A4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JQ5-M4A4A_HUMAN
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 4A
    Protein Accession:
    Q96JQ5
    Secondary Accessions:
    • Q8TEZ6
    • Q96PG7
    • Q9BY18
    • Q9H3V3
    • Q9P1S3

    Protein attributes for MS4A4A Gene

    Size:
    239 amino acids
    Molecular mass:
    25441 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF65507.1; Type=Frameshift; Positions=33; Evidence={ECO:0000305}; Sequence=AAK37594.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL08486.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL56220.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB18738.1; Type=Frameshift; Positions=34; Evidence={ECO:0000305};

    Alternative splice isoforms for MS4A4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MS4A4A Gene

Post-translational modifications for MS4A4A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MS4A4A Gene

Domains & Families for MS4A4A Gene

Gene Families for MS4A4A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MS4A4A Gene

Suggested Antigen Peptide Sequences for MS4A4A Gene

GenScript: Design optimal peptide antigens:
  • Four-span transmembrane protein 1 (M4A4A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96JQ5

UniProtKB/Swiss-Prot:

M4A4A_HUMAN :
  • Belongs to the MS4A family.
Family:
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A4A: view

Function for MS4A4A Gene

Molecular function for MS4A4A Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.

Phenotypes From GWAS Catalog for MS4A4A Gene

Gene Ontology (GO) - Molecular Function for MS4A4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 30833792
genes like me logo Genes that share ontologies with MS4A4A: view
genes like me logo Genes that share phenotypes with MS4A4A: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A4A Gene

Localization for MS4A4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A4A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A4A gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A4A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MS4A4A Gene

Pathways & Interactions for MS4A4A Gene

PathCards logo

SuperPathways for MS4A4A Gene

No Data Available

Interacting Proteins for MS4A4A Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q96JQ5-M4A4A_HUMAN ENSP00000338648 for MS4A4A Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for MS4A4A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MS4A4A Gene

Drugs & Compounds for MS4A4A Gene

No Compound Related Data Available

Transcripts for MS4A4A Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A4A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1:
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for MS4A4A Gene

GeneLoc Exon Structure for
MS4A4A
ECgene alternative splicing isoforms for
MS4A4A

Expression for MS4A4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A4A Gene

This gene is overexpressed in Whole Blood (x7.0), Adipose - Visceral (Omentum) (x4.8), and Spleen (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of MS4A4A Gene:

MS4A4A

SOURCE GeneReport for Unigene cluster for MS4A4A Gene:

Hs.325960

mRNA Expression by UniProt/SwissProt for MS4A4A Gene:

Q96JQ5-M4A4A_HUMAN
Tissue specificity: Variable expression in multiple hemopoietic cell lines.

Evidence on tissue expression from TISSUES for MS4A4A Gene

  • Spleen(4.4)
  • Lymph node(4.3)
  • Blood(4)
genes like me logo Genes that share expression patterns with MS4A4A: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A4A Gene

Orthologs for MS4A4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MS4A4A 33 32
  • 99.58 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ms4a4a 17 32
  • 70.49 (n)
Ms4a4c 33
  • 40 (a)
OneToMany
Ms4a4b 33
  • 38 (a)
OneToMany
Ms4a4d 33
  • 37 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC476900 32
  • 67.8 (n)
MS4A4A 33
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 38 (a)
OneToMany
-- 33
  • 37 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 33 (a)
OneToMany
-- 33
  • 33 (a)
OneToMany
-- 33
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 30 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ms4a17a.14 33
  • 32 (a)
ManyToMany
ms4a17a.10 33
  • 29 (a)
ManyToMany
ms4a17a.7 33
  • 29 (a)
ManyToMany
ms4a17a.5 33
  • 28 (a)
ManyToMany
FP015791.1 33
  • 28 (a)
ManyToMany
ms4a17a.11 33
  • 28 (a)
ManyToMany
si:dkey-238j22.1 33
  • 28 (a)
ManyToMany
ms4a17a.9 33
  • 28 (a)
ManyToMany
ms4a17a.1 33
  • 27 (a)
ManyToMany
si:ch73-56d11.3 33
  • 26 (a)
ManyToMany
si:dkey-174k12.3 33
  • 26 (a)
ManyToMany
ms4a17a.8 33
  • 26 (a)
ManyToMany
ms4a17a.6 33
  • 26 (a)
ManyToMany
ms4a17a.2 33
  • 26 (a)
ManyToMany
si:dkey-77f5.10 33
  • 25 (a)
ManyToMany
si:ch73-56d11.4 33
  • 25 (a)
ManyToMany
ms4a17a.4 33
  • 25 (a)
ManyToMany
ms4a17a.3 33
  • 25 (a)
ManyToMany
ms4a17c.2 33
  • 25 (a)
ManyToMany
ms4a17c.1 33
  • 24 (a)
ManyToMany
ms4a17a.17 33
  • 23 (a)
ManyToMany
Species where no ortholog for MS4A4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A4A Gene

ENSEMBL:
Gene Tree for MS4A4A (if available)
TreeFam:
Gene Tree for MS4A4A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MS4A4A: view image

Paralogs for MS4A4A Gene

(4) SIMAP similar genes for MS4A4A Gene using alignment to 3 proteins:

  • M4A4A_HUMAN
  • F8W866_HUMAN
  • H0YE49_HUMAN

Pseudogenes.org Pseudogenes for MS4A4A Gene

genes like me logo Genes that share paralogs with MS4A4A: view

Variants for MS4A4A Gene

Sequence variations from dbSNP and Humsavar for MS4A4A Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000071211 -- 60,303,448(+) C/T intron_variant
rs1000123367 -- 60,303,232(+) T/G intron_variant
rs1000137497 -- 60,280,845(+) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000180184 -- 60,279,557(+) T/C upstream_transcript_variant
rs1000639620 -- 60,287,545(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A4A Gene

Variant ID Type Subtype PubMed ID
nsv1053558 CNV loss 25217958
nsv1145537 CNV deletion 24896259
nsv832174 CNV gain 17160897

Variation tolerance for MS4A4A Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MS4A4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MS4A4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A4A Gene

Disorders for MS4A4A Gene

Additional Disease Information for MS4A4A

No disorders were found for MS4A4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A4A Gene

Publications for MS4A4A Gene

  1. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PMID: 11245982) Ishibashi K … Imai M (Gene 2001) 2 3 4 56
  2. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y … Tedder TF (Genomics 2001) 2 3 4 56
  3. Structural organization of the human MS4A gene cluster on Chromosome 11q12. (PMID: 11486273) Liang Y … Tedder TF (Immunogenetics 2001) 3 4 23 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. (PMID: 30833792) Hubel P … Pichlmair A (Nature immunology 2019) 3 56

Products for MS4A4A Gene

Sources for MS4A4A Gene